[Pretreatment of organophosphate poisoning: potential interests of huperzine A].

Abstract

Pyridostigmine which is widely used as pretreatment of organophosphate poisoning protects cholinesterases of peripheral nervous system. Other molecules able to also protect the central nervous system are under study and, among them, huperzine A. This paper gives an overview of the current investigations about the efficacy and the innocuity of this molecule (study of the mechanisms of action, biological targets, behavioural manifestations) and brings out its potential interests.

• Authors: G Lallement
• Journal: Annales pharmaceutiques francaises (Ann Pharm Fr) Vol. 58 Issue 1 Pg. 13-7 (Jan 2000) ISSN: 0003-4509 [Print] France
• Vernacular Title: Prétraitement de l'intoxication organophosphorée: intérêts potentiels de l'huperzine A.
• PMID: 10669806 (Publication Type: English Abstract, Journal Article)

Chemical References

• Alkaloids
• Antidotes
• Cholinesterase Inhibitors
• Organophosphorus Compounds
• Sesquiterpenes
• huperzine A

Topics

• Alkaloids
• Antidotes (therapeutic use)
• Cholinesterase Inhibitors (therapeutic use)
• Humans
• Organophosphate Poisoning
• Organophosphorus Compounds (antagonists & inhibitors)
• Poisoning (prevention & control)
• Sesquiterpenes (therapeutic use)