Abstract | BACKGROUND: METHODS: Sixty-five children with anal fissure were divided randomly into 3 groups. Each group received double-blinded a topical ointment that contained either 0.2% GTN, 10% lidocaine, or placebo. These ointments were applied to the lowest part of the anal canal twice daily. Patients were periodically reviewed, and the study was ended after 8 weeks. RESULTS: Complete healing of the fissure occurred in 26 of 31 (83.9%) patients treated with GTN, 7 of 14 (50%) patients treated with lidocaine, and 6 of 17 (35.2%) treated with placebo. In 29 of 31 (93.5%) GTN-treated patients, a total relief of symptoms was observed, whereas this occurred in 7 of 14 (50%) treated with lidocaine and 6 of 11 (35.3%) in the placebo group. The differences between the study group and control groups were highly statistically significant (P < .001). CONCLUSION: The majority of children suffering from anal fissure will be cured and have relief of symptoms after topical application of GTN ointment to the anal canal.
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Authors | B Tander, A Güven, S Demirbağ, Y Ozkan, H Oztürk, S Cetinkurşun |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 34
Issue 12
Pg. 1810-2
(Dec 1999)
ISSN: 0022-3468 [Print] United States |
PMID | 10626860
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Ointments
- Vasodilator Agents
- Nitroglycerin
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Topics |
- Child
- Child, Preschool
- Double-Blind Method
- Female
- Fissure in Ano
(drug therapy)
- Humans
- Infant
- Male
- Nitroglycerin
(therapeutic use)
- Ointments
- Prospective Studies
- Treatment Outcome
- Vasodilator Agents
(therapeutic use)
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