Abstract | BACKGROUND & AIMS: METHODS: Twenty-two patients with refractory Crohn's disease ( Crohn's Disease Activity Index [CDAI] > 200 and/or draining perianal disease) initiated therapy with thalidomide, 200 mg at bedtime (18 patients), or 300 mg at bedtime (4 patients). CDAI and goal interval scores (GIS) were assessed at weeks 0, 4, and 12. Clinical response for patients with luminal disease was defined as reduction in CDAI score of >150 points and for fistula patients was 2 scores of >/=1+ in 3 parameters of the GIS. Clinical remission was defined as a total CDAI < 150 ( luminal patients) or >/=2+ for all parameters of the GIS ( fistula patients). RESULTS: Nine patients with luminal disease and 13 with fistulas (16 male, 6 female) were enrolled. The median CDAI score at entry was 371 (95-468). Sixteen patients completed 4 weeks of treatment (12 clinical responses, 4 clinical remissions). All 14 patients completing 12 weeks met criteria for clinical response. Nine achieved clinical remission (3 luminal, 6 fistula patients). The median CDAI score was 175 (30-468; P < 0.001 vs. baseline). CONCLUSIONS:
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Authors | E D Ehrenpreis, S V Kane, L B Cohen, R D Cohen, S B Hanauer |
Journal | Gastroenterology
(Gastroenterology)
Vol. 117
Issue 6
Pg. 1271-7
(Dec 1999)
ISSN: 0016-5085 [Print] United States |
PMID | 10579967
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Tumor Necrosis Factor-alpha
- Thalidomide
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Topics |
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects, therapeutic use)
- Crohn Disease
(drug therapy)
- Electromyography
- Female
- Humans
- Male
- Middle Aged
- Thalidomide
(adverse effects, therapeutic use)
- Treatment Outcome
- Tumor Necrosis Factor-alpha
(antagonists & inhibitors)
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