A case of acute lymphoblastic leukemia and thorotrast-accumulation.

Abstract

A case of acute lymphoblastic leukemia (ALL), in a 50 years old patient, 26 years after thorotrast injection, is reported. In spite of intensive therapy, he died 2 years after diagnosis of disease. The cytogenetic showed the usual thorotrast radiation-induced abnormalities, although to a greater extent than reported in leterature. Furthermore a hypodiploidy was present, which was connected with ALL. In addition the patient exhibited the interesting phenomenon of giant satellites on one of his D14-chromosomes. This abnormally was found also in his mother and son. The question arises, how far the inherited cytogenetic pattern and the thorotrast radiation each contributed to the development of ALL.

• Authors: M A Gobets, H Nowotny, F Ruzicka, H Hanak, A Stacher
• Journal: Blut (Blut) Vol. 31 Issue 1 Pg. 5-10 (Jul 1975) ISSN: 0006-5242 [Print] Germany
• PMID: 1056803 (Publication Type: Journal Article)

Chemical References

• Thorium Dioxide

Topics

• Bone Marrow Examination
• Cerebral Hemorrhage (etiology)
• Chromosome Aberrations
• Humans
• Karyotyping
• Leukemia, Lymphoid (genetics, pathology)
• Leukemia, Radiation-Induced
• Liver (pathology)
• Lymph Nodes (pathology)
• Male
• Middle Aged
• Spleen (pathology)
• Thorium Dioxide (adverse effects)