Lomustine (CCNU) for the treatment of resistant lymphoma in dogs.

Abstract

Forty-three dogs with lymphoma that had relapsed or had failed to achieve complete remission to previous chemotherapy were treated with lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea [CCNU]) at a dosage of 90-100 mg/m2 body surface area p.o. every 3 weeks. Durable complete or partial responses occurred in 11 dogs for a median of 86 days. The acutely dose-limiting toxicosis was neutropenia 7 days after administration, resulting in a recommended dosage of 90 mg/m2. Cumulative thrombocytopenia occurred in dogs receiving continued CCNU treatment, and a dose interval of 3 weeks may be too short for continued administration of this drug. Toxicoses evident as fever or central nervous system signs or renal damage were uncommon or rare. CCNU is effective in the treatment of relapsed lymphoma.

• Authors: A S Moore, C A London, C A Wood, L E Williams, S M Cotter, D A L'Heureux, A E Frimberger
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 1999 Sep-Oct Vol. 13 Issue 5 Pg. 395-8 ISSN: 0891-6640 [Print] United States
• PMID: 10499719 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Alkylating
• Lomustine

Topics

• Animals
• Antineoplastic Agents, Alkylating (adverse effects, therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Drug Resistance, Neoplasm
• Female
• Lomustine (adverse effects, therapeutic use)
• Lymphoma (drug therapy, veterinary)
• Male
• Neutropenia (chemically induced)
• Recurrence
• Thrombocytopenia (chemically induced)
• Treatment Outcome