[The effect of SR 142801, a blocker of tachykinin NK-3 receptors, on synaptic transmission in the rat caudal mesenteric ganglion].

Abstract

Effects of tachykinin NK-3 receptors antagonist SR 142801 on the synaptic transmission in the rat's caudal mesenteric ganglion were investigated using extracellular recording of compound action potentials (CAPs) from the ganglion nerves. It is shown that antagonist of NK-3 receptors SR 142801 (2.5.10(-7) mol/l) decreased the amplitude and square of CAPs obtained by stimulating of intermesenteric nerve (IMN) and leading off from the colonic nerve, after high-frequency stimulation of IMN. It is suggests that tachykinin NK-3 receptors take part in SP-ergic synaptic transmission through the rat's caudal mesenteric ganglion.

• Authors: O M Pasichnichenko, V I Skok
• Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) (Fiziol Zh (1994)) Vol. 45 Issue 4 Pg. 55-60 ( 1999) ISSN: 2522-9028 [Print] Ukraine
• Vernacular Title: Vplyv blokatora SR 142801 takhikininovykh NK3, retseptoriv na synaptychnu peredachu u kaudal'nomu bryzhovomu hanhliï shchura.
• PMID: 10474803 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Ganglionic Blockers
• Hexamethonium Compounds
• Piperidines
• Receptors, Neurokinin-3
• SR 142801
• benzohexonium

Topics

• Action Potentials (drug effects, physiology)
• Animals
• Female
• Ganglia, Sympathetic (drug effects, physiology)
• Ganglionic Blockers (pharmacology)
• Hexamethonium Compounds (pharmacology)
• In Vitro Techniques
• Male
• Mesenteric Arteries (innervation)
• Piperidines (pharmacology)
• Rats
• Receptors, Neurokinin-3 (antagonists & inhibitors, drug effects, physiology)
• Synaptic Transmission (drug effects, physiology)