Muscle necrosis in rats induced by 2-methoxy-p-phenylenediamine.

Abstract

p-Phenylenediamine, together with several of its amino and alkyl derivatives, are known to be myotoxic in animals and man. In the present study, it was found that 2-methoxy-p-phenylenediamine, a component of oxidative hair dyes, similarly causes necrosis of skeletal muscle (gastrocnemius, diaphragm and tongue) in rats. The myotoxicity of 2-methoxy-p-phenylenediamine was much greater than that of p-phenylenediamine itself. This observation is consistent with the relative efficacy of these substances in disrupting mitochondrial metabolism, an effect which is believed to be responsible for the selective toxicity of p-phenylenediamine derivatives to muscle.

• Authors: R Munday, E Manns
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 37 Issue 5 Pg. 561-4 (May 1999) ISSN: 0278-6915 [Print] England
• PMID: 10456685 (Publication Type: Journal Article)

Chemical References

• Anisoles
• Oxidants
• Phenylenediamines
• 1,4-diamino-2-methoxybenzene

Topics

• Animals
• Anisoles (toxicity)
• Dose-Response Relationship, Drug
• Female
• Muscle, Skeletal (drug effects, pathology)
• Necrosis
• Oxidants (toxicity)
• Phenylenediamines (toxicity)
• Rats
• Rats, Sprague-Dawley
• Toxicity Tests