Abstract | PURPOSE: To determine the incidence of post-discharge nausea and vomiting (PDNV) following outpatient laparoscopic procedures in women, and to assess the efficacy of the prophylactic administration of promethazine prior to discharge from hospital. METHODS: RESULTS: After discharge home, the overall incidence of nausea was 48%, moderate to severe nausea 30%, vomiting 17% and rescue antiemetic use 28%, with no difference between those receiving saline or promethazine. The need for antiemetics in the PAR was associated with subsequent PDNV, with those requiring PAR antiemetics being four times as likely to vomit after discharge (P = 0.008). CONCLUSION: Despite the prophylactic administration of 0.5 mg droperidol i.v., patients undergoing ambulatory laparoscopic surgery reported a high incidence of nausea after discharge. Patients requiring antiemetics in the PAR were at higher risk for PDNV. The incidence of nausea was not altered by prophylactic administration of 0.6 mg x kg(-1) promethazine i.m. before discharge.
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Authors | J L Parlow, A T Meikle, J van Vlymen, N Avery |
Journal | Canadian journal of anaesthesia = Journal canadien d'anesthesie
(Can J Anaesth)
Vol. 46
Issue 8
Pg. 719-24
(Aug 1999)
ISSN: 0832-610X [Print] United States |
PMID | 10451129
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Adult
- Ambulatory Surgical Procedures
- Antiemetics
(therapeutic use)
- Cholecystectomy
(adverse effects)
- Double-Blind Method
- Female
- Gynecologic Surgical Procedures
- Humans
- Laparoscopy
(adverse effects)
- Postoperative Complications
(chemically induced, psychology)
- Postoperative Nausea and Vomiting
(epidemiology, prevention & control)
- Promethazine
(therapeutic use)
- Prospective Studies
- Risk Assessment
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