[Acute renal failure, intravascular hemolysis and toxic hepatitis caused by repeated use of rifampicin (case report)].

Abstract

We report the case of a 57-year-old man treated with interrupted rifampicin therapy for urinary tract tuberculosis who experienced acute renal failure, intravascular hemolysis and toxic hepatitis. This combined adverse reactions are rare. Supportive treatment with dialysis and withdrawal of rifampicin result with complete recovery. Interrupted and intermittent therapy with rifampicin should be avoided and noncompliant patients should be given alternative treatment when possible.

• Authors: S Sefer, M Ivanusa, P Kes, I Ratković-Gusić, D Vasilj
• Journal: Lijecnicki vjesnik (Lijec Vjesn) 1999 Apr-May Vol. 121 Issue 4-5 Pg. 126-8 ISSN: 0024-3477 [Print] Croatia
• Vernacular Title: Akutno bubrezno zatajenje, intravaskularna hemoliza i toksicni hepatitis uzrokovani opetovanim uzimanjem rifampicina (prikaz bolesnika).
• PMID: 10437356 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibiotics, Antitubercular
• Rifampin

Topics

• Acute Kidney Injury (chemically induced)
• Antibiotics, Antitubercular (poisoning, therapeutic use)
• Chemical and Drug Induced Liver Injury (etiology)
• Hemolysis
• Humans
• Male
• Middle Aged
• Rifampin (poisoning, therapeutic use)
• Tuberculosis, Urogenital (drug therapy)