Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis - hepatitis B virus - inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines?

Abstract

UNLABELLED:

Does concomitant injection of a combined diphtheria-tetanus-acellular pertussis - hepatitis B virus - inactivated polio virus vaccine influence the reactogenicity and immunogenicity of commercial Haemophilus influenzae type b conjugate vaccines? The immunogenic responses and local reactions to four Haemophilus influenzae type b (Hib) conjugate vaccines licensed for primary immunisation (Hiberix, ActHib, Pedvax, HibTITER) when administered concomitantly but in the opposite thigh with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine were studied in 549 healthy infants at 3, 4.5 and 6 months of age. Local reactions were mild, but different between the four groups, a tetanus conjugate Hib vaccine showing the fewest reactions. All local reactions resolved without sequelae. There was no apparent general reaction. The immunogenic response was similar with all four vaccines, geometric mean concentrations ranging from 4.95 to 7.2 microg/ml. All but one subject had antipolyribosylribitol phosphate polysaccharide antibody titres > or =0.15 microg/ml, and 88.0% to 96% achieved high titres (>1.0 microg/ml) generally associated with long-term protection against Hib disease.

CONCLUSION:

There does not appear to be any interference with the immune response when current commercial Haemophilus influenzae type b conjugate vaccines are concomitantly administered with a candidate diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated polio virus vaccine as separate injections.

• Authors: V Usonis, V Bakasenas
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 158 Issue 5 Pg. 398-402 (May 1999) ISSN: 0340-6199 [Print] Germany
• PMID: 10333123 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Antibodies, Viral
• Bacterial Proteins
• Diphtheria-Tetanus-Pertussis Vaccine
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines
• Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
• Haemophilus influenzae type b polysaccharide vaccine
• Hepatitis B Vaccines
• Poliovirus Vaccine, Inactivated
• Polysaccharides, Bacterial
• Tetanus Toxoid
• Vaccines, Combined
• Vaccines, Conjugate
• HibTITER protein, Haemophilus influenzae

Topics

• Antibodies, Bacterial (biosynthesis)
• Antibodies, Viral (biosynthesis)
• Bacterial Capsules
• Bacterial Proteins (administration & dosage, immunology)
• Diphtheria-Tetanus-Pertussis Vaccine (administration & dosage, immunology)
• Diphtheria-Tetanus-acellular Pertussis Vaccines
• Haemophilus Vaccines (administration & dosage, immunology)
• Hepatitis B Vaccines (administration & dosage, immunology)
• Humans
• Infant
• Poliovirus Vaccine, Inactivated (administration & dosage, immunology)
• Polysaccharides, Bacterial (administration & dosage, immunology)
• Tetanus Toxoid (administration & dosage, immunology)
• Vaccination (adverse effects)
• Vaccines, Combined (administration & dosage, immunology)
• Vaccines, Conjugate (administration & dosage, immunology)