Abstract |
In PET studies we have shown the usefulness of cobalt radionuclides for the visualization and quantification of ischaemic damage in stroke. In the present study, we explored 57Co2+ as a SPET tracer. Uptake of radioactivity was estimated by using a cobalt enhancement ratio defined as the ratio of cobalt uptake in the affected region versus a similar volume in the non-affected contralateral side. Clinical status was assessed with the Orgogozo stroke score at the time of scanning and at least 60 days after admission. Nineteen patients (11 men, 8 women) with a middle cerebral artery stroke were examined with 57Co2+ SPET 0-30 days after stroke onset. Our investigations show enhanced cobalt uptake in the infarcted brain tissue in patients with a major stroke and little clinical improvement. There was a significant correlation between the cobalt enhancement ratio and the Orgogozo score at the time of scanning and discharge. Our results suggest that 57Co2+ SPET is suitable for determining the extent of (possibly calcium-mediated) damage in stroke and in the assessment of potential therapeutic interventions.
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Authors | H Stevens, S Knollema, D A Piers, C Van de Wiele, H M Jansen, A E De Jager, J De Reuck, R A Dierckx, J Korf |
Journal | Nuclear medicine communications
(Nucl Med Commun)
Vol. 19
Issue 6
Pg. 573-80
(Jun 1998)
ISSN: 0143-3636 [Print] England |
PMID | 10234662
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cobalt Radioisotopes
- Radiopharmaceuticals
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Topics |
- Adult
- Aged
- Brain
(diagnostic imaging)
- Brain Damage, Chronic
(diagnostic imaging, etiology)
- Cerebral Arteries
- Cerebrovascular Disorders
(complications, diagnostic imaging)
- Cobalt Radioisotopes
(pharmacokinetics)
- Female
- Humans
- Male
- Middle Aged
- Radiopharmaceuticals
(pharmacokinetics)
- Tissue Distribution
- Tomography, Emission-Computed, Single-Photon
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