Comparative study of efficacy of plasma exchange versus intravenous gammaglobulin treatment on acute postinfectious polyradiculoneuropathy: a preliminary report.

Abstract

We tried to compare the efficacy of plasma exchange (PE) with that of intravenous immunoglobulin (IVIG) in patients with postinfectious polyneuritis (Guillain-Barré syndrome [GBS] and cranial neuritis). Fifteen patients with postinfectious polyneuritis were divided into 2 groups. The IVIG group included 5 cases of GBS and 2 cases of postinfectious cranial neuritis (ophthalmoplegic type). The PE group included 5 cases of GBS and 3 cases of postinfectious cranial neuritis (ophthalmoplegic type). The changes and incidences of improvement of muscle strength scores (MSSs) and ocular movement scores (OMSs) were evaluated before treatment and 1, 2, 3, and 4 weeks after treatment. No significant differences between the IVIG and PE groups were found in the MSSs or OMSs at any time after treatment. These data suggested that PE and IVIG had equivalent efficacy. In the IVIG group, the proportion of suppressor-inducer T cells significantly increased (p < 0.01) (before versus after treatment), and the proportion of suppressor-effector cells also increased but not significantly (before versus after treatment). In the PE group, the percentage of suppressor-inducer T cells significantly decreased (p < 0.05) (before versus after treatment) while the proportion of suppressor/cytotoxic T cells significantly increased (p < 0.05) (before versus after treatment). The percentage of suppressor-effector T cells also increased (before versus after treatment) but not significantly.

• Authors: T Hosokawa, K Hamaguchi, R Tomioka, T Tsuji, K Nomura, R Ohno, H Okada, K Moriwaki, S Sugawara, H Nakamoto, H Suzuki, K Shimazu
• Journal: Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis (Ther Apher) Vol. 2 Issue 4 Pg. 288-91 (Nov 1998) ISSN: 1091-6660 [Print] United States
• PMID: 10227757 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Acute Disease
• Cranial Nerves
• Eye Movements (physiology)
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Infections (complications)
• Muscles (physiology)
• Neuritis (therapy)
• Plasma Exchange
• Polyradiculoneuropathy (etiology, therapy)
• T-Lymphocytes, Regulatory (cytology)
• Treatment Outcome