[The pathogenesis of liver functional disorders after cholecystectomy in cholelithiasis].

Abstract

AIM:

To study hepatic function after cholecystectomy and the role of absorptive-excretory function of the liver and hormonal factors in development of postcholecystectomy syndrome.

MATERIALS AND METHODS:

106 patients long after cholecystectomy for cholelithiasis were examined for absorptive-excretory function of the liver and blood hormones (hydrocortisone, insulin, gastrin, thyroxine, triiodothyronine, thyrotropine). I-131-bengal-rose hepatography, dynamic hepatobiliscintigraphy with brommeside-Tc-99m, radioimmunoassay were employed.

RESULTS:

Impairment, often subclinical, of hepatic absorption and excretion after cholecystectomy was found in 94% of the patients. External function of the liver after cholecystectomy was disturbed depending on the condition of its absorptive-excretory function. Hepatic dysfunctions and changes in blood hormones correlated.

CONCLUSION:

Absorptive-excretory function and hormonal factors are essential in pathogenesis of postcholecystectomy syndrome.

• Authors: E M Aksenova, Ia M Vakhrushev
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 71 Issue 2 Pg. 48-52 ( 1999) ISSN: 0040-3660 [Print] Russia (Federation)
• Vernacular Title: O patogeneze narusheniĭ funktsii pecheni posle kholetsistéktomii pri zhelchnokamennoĭ bolezni.
• PMID: 10222554 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hormones
• Neurotransmitter Agents

Topics

• Cholelithiasis (blood, complications, physiopathology, surgery)
• Chronic Disease
• Female
• Follow-Up Studies
• Hormones (blood)
• Humans
• Liver (physiopathology)
• Liver Diseases (blood, etiology, physiopathology)
• Liver Function Tests
• Male
• Middle Aged
• Neurotransmitter Agents (blood)
• Postcholecystectomy Syndrome (blood, etiology, physiopathology)