Glossoptosis

Posterior displacement of the TONGUE toward the PHARYNX. It is often a feature in syndromes such as in PIERRE ROBIN SYNDROME and DOWN SYNDROME and associated with AIRWAY OBSTRUCTION during sleep (OBSTRUCTIVE SLEEP APNEAS).

Also Known As:

Networked: 28 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Micrognathism
2.	Airway Obstruction (Choking)
3.	Obstructive Sleep Apnea
4.	Failure to Thrive
5.	Pierre Robin Syndrome (Syndrome, Pierre Robin)

Experts

1.	Manica, Denise: 3 articles (05/2022 - 01/2017)
2.	Schweiger, Cláudia: 3 articles (05/2022 - 01/2017)
3.	Kuhl, Gabriel: 2 articles (05/2022 - 01/2017)
4.	Marostica, Paulo José Cauduro: 2 articles (05/2022 - 01/2017)
5.	Kuhl, Leonardo Palma: 1 article (05/2022)
6.	Macedo, Alexandre José: 1 article (05/2022)
7.	Sekine, Leo: 1 article (05/2022)
8.	Siebert, Marina: 1 article (05/2022)
9.	Abe, Takafumi: 1 article (05/2022)
10.	Giga, Mayumi: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glossoptosis:

1.	Oxygen (Dioxygen)IBA 11/01/2023 - "Laryngoscopy views, glossoptosis degree, polysomnography (PSG) results, oxygen saturations and airway measurements were compared pre- and post-MDO. " 12/01/2000 - "Cases of glossoptosis, in which the tongue moved posteriorly during sleep and abutted the posterior pharynx, resulting in airway obstruction and oxygen desaturation, were identified. "
2.	Mediator ComplexIBA 01/01/2021 - "Here, we show that conditional loss of a Mediator complex subunit protein, Med23 in mouse neural crest cells (Med23fx/fx;Wnt1-Cre), results in micrognathia, glossoptosis, and cleft palate, mimicking the phenotype of Pierre Robin sequence. "
3.	Protein Subunits (Protein Subunit)IBA 01/01/2021 - "Here, we show that conditional loss of a Mediator complex subunit protein, Med23 in mouse neural crest cells (Med23fx/fx;Wnt1-Cre), results in micrognathia, glossoptosis, and cleft palate, mimicking the phenotype of Pierre Robin sequence. "
4.	Alfentanil (Alfenta)FDA LinkGeneric 01/01/2023 - "Time to fall asleep, sedation score, time to end of medication, time to open eyes, recovery score, and the presence of body movement, glossoptosis, arousal or jaw support during hypoxia, hypotension, bradycardia, operation time, total amount of remimazolam and alfentanil used, and the presence of postoperative complications such as pruritus, dizziness, nausea, and vomiting were recorded in both 2 groups. "
5.	Dopamine Agents (Dopaminergic Agents)IBA 01/01/2013 - "His chief complaint was glossoptosis with jaw-opening dystonia associated with rapid dose-elevation and/or overdose of dopaminergic drugs. "
6.	SuspensionsIBA 11/01/2013 - "Treatment of obstructive sleep apnea hypopnea syndrome caused by glossoptosis with tongue-base suspension."
7.	Phenytoin (Dilantin)FDA LinkGeneric 03/01/1990 - "We describe a unique case of massive phenytoin-induced gingival overgrowth causing glossoptosis and subsequent upper airway obstruction. "
8.	remimazolamIBA 01/01/2023 - "Time to fall asleep, sedation score, time to end of medication, time to open eyes, recovery score, and the presence of body movement, glossoptosis, arousal or jaw support during hypoxia, hypotension, bradycardia, operation time, total amount of remimazolam and alfentanil used, and the presence of postoperative complications such as pruritus, dizziness, nausea, and vomiting were recorded in both 2 groups. "

Therapies and Procedures

1.	Conservative Treatment 03/01/1963 - "A contribution to the conservative treatment of microgenia and glossoptosis]." 04/01/2010 - "Since dyspnoea was not improved by conservative treatment, a phi0.8-mm Kirschner wire was set inside a nasopharyngeal airway bent in a form to lift the root of the tongue in order to prevent glossoptosis. " 01/01/1996 - "For some children with a diagnosis of Robin syndrome the conservative treatment will not be sufficient due to recurrent glossoptosis and acute obturation of the airways which leads to asphyxia. "
2.	Bone Wires 04/01/2010 - "Since dyspnoea was not improved by conservative treatment, a phi0.8-mm Kirschner wire was set inside a nasopharyngeal airway bent in a form to lift the root of the tongue in order to prevent glossoptosis. "
3.	Distraction Osteogenesis 09/01/2009 - "The objective of this study was to evaluate the long-term success of mandibular distraction osteogenesis in patients with mandibular airway obstruction syndrome (MAOS), defined as obstructive sleep apnea, swallowing abnormalities, and failure to thrive in the presence of micrognathia, glossoptosis, gastroesophageal or laryngeal reflux, and microaspiration. "
4.	Tracheostomy 03/01/2023 - "To evaluate the bacterial microbiome found in tracheostomy cannulas of a group of children diagnosed with glossoptosis secondary to Robin Sequence (RS), and its clinical implications. " 03/01/2021 - "His airway had been secured with a tracheostomy, and a gastric tube had been inserted; however, he continued to suffer from urinary tract infections, glossoptosis, and silent aspiration of saliva. " 04/01/2012 - "Nasal endotube passing through a narrowing oropharynx region or oral airway is life-saving before tracheostomy is performed on patients with Nager syndrome and restricted jaw opening and glossoptosis." 11/01/2020 - "Previously, severe upper airway obstruction in patients with retrognathia and glossoptosis has been managed with tracheostomy. " 01/01/2021 - "We describe the case of a 6.5-year-old boy with a history of PRS (a triad of micrognathia, glossoptosis, and airway obstruction), tracheostomy, and subglottic fibrosis who required general anesthesia. "
5.	Airway Management 02/01/2018 - "Pediatric otolaryngologists are frequently called to assist in difficult airway management in newborns with Pierre Robin Sequence (PRS) who have microretrognathia, glossoptosis, and an anterior larynx. " 03/01/1998 - "Airway management is a major concern in Robin sequence, where micrognathia, glossoptosis and a cleft of the soft palate exist. "