Transcatheter Aortic Valve Replacement

Surgical treatment for severe AORTIC VALVE STENOSIS. Transcatheter aortic valve replacement (TAVR) is used as an alternative option in patients who are deemed at high risk or inoperable for traditional open-heart surgery.

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Networked: 6740 relevant articles (258 outcomes, 757 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Rodés-Cabau, Josep: 162 articles (10/2022 - 12/2009)
2.	Webb, John G: 141 articles (09/2022 - 05/2008)
3.	Leon, Martin B: 128 articles (11/2022 - 01/2006)
4.	Barbanti, Marco: 112 articles (11/2022 - 04/2010)
5.	Latib, Azeem: 106 articles (11/2022 - 04/2010)
6.	Tamburino, Corrado: 106 articles (02/2022 - 01/2010)
7.	Windecker, Stephan: 103 articles (11/2022 - 11/2009)
8.	Colombo, Antonio: 98 articles (11/2022 - 04/2010)
9.	Thourani, Vinod H: 89 articles (11/2022 - 06/2011)
10.	Nombela-Franco, Luis: 85 articles (10/2022 - 01/2012)

Related Diseases

1.	Aortic Valve Stenosis (Aortic Stenosis) 07/01/2020 - "It remains unclear whether transcatheter aortic valve implantation (TAVI) is cost-effective for treating intermediate-low risk severe aortic stenosis (AS) patients in a highly efficient healthcare system. " 10/01/2015 - "Transcatheter Aortic-Valve Implantation (TAVI) is considered to be highly effective in the treatment of high-risk patients with severe aortic stenosis. " 05/01/2010 - "The gold standard treatment for aortic stenosis remains thoracotomy and surgical replacement of the valve; to this end it is essential that surgeons play a central role in the decision-making processes for transcatheter aortic valve implantation and that they embrace this new and exciting technology, which promises to dramatically change the way their high-risk aortic valve patients are managed over the course of the next 10 years." 10/01/2021 - "Transcatheter aortic valve implantation (TAVI) has proven efficacy in the treatment of aortic stenosis (AS). " 05/01/2020 - "Transcatheter aortic valve implantation (TAVI) is a safe and effective treatment for inoperable, intermediate- or high-risk patients with severe symptomatic aortic stenosis and has been associated with excellent clinical outcomes. "
2.	Aortic Valve Insufficiency (Aortic Regurgitation) 01/01/2021 - "The balloon-expandable SAPIEN 3 (S3) is superior to the older-generation balloon-expandable SAPIEN XT (XT) in a lower incidence of paravalvular aortic regurgitation, lower complication rates and better survival in transcatheter aortic valve implantation (TAVI). " 01/01/2022 - "This report offers some guidance for treating patients with existing apicoaortic conduits and suggests that transcatheter aortic valve replacement is safe and effective if native aortic valve insufficiency develops." 01/01/2023 - "Procedural success and clinical outcomes after transcatheter aortic valve replacement (TAVR) have improved, but residual aortic regurgitation (AR) and new permanent pacemaker implantation (PPI) rates remain variable because of a lack of uniform periprocedural management and implantation. " 09/29/2020 - "Improved Transcatheter aortic valve implantation for aortic regurgitation using a new-type stent: the first preclinical experience." 12/01/2020 - "This is a large-scale single-center study to evaluate the safety and efficacy of transcatheter aortic valve replacement in treating aortic regurgitation."
3.	Mitral Valve Insufficiency (Mitral Regurgitation) 03/23/2022 - "Pre-procedure mitral regurgitation (MR) is a frequent coexistent finding in patients undergoing transcatheter aortic valve replacement (TAVR), and most of them (up to 55%) experience a significant improvement in MR after the procedure. " 11/01/2015 - "Significant Reduction in Mitral Regurgitation Volume Is the Main Contributor for Increase in Systolic Forward Flow in Patients with Functional Mitral Regurgitation after Transcatheter Aortic Valve Replacement: Hemodynamic Analysis Using Echocardiography." 10/01/2021 - "CT Assessment of the Mitral Annulus Predicts Improvement in Coexistent Mitral Regurgitation Following Transcatheter Aortic Valve Replacement." 10/01/2021 - "Conclusion Concomitant mitral regurgitation in patients undergoing transcatheter aortic valve replacement (TAVR) tends to improve after the procedure, with maximum improvement in the 1st year after TAVR. " 01/01/2020 - "The influence of improved mitral regurgitation (MR) on the outcomes of transcatheter aortic valve replacement (TAVR) is unknown. "
4.	Hemorrhage 10/01/2023 - "As the antithrombotic regimen that may best prevent ischaemic complications along with the lowest bleeding risk offset following transcatheter aortic valve implantation (TAVI) remains unclear, we aimed to compare the safety and efficacy of antithrombotic regimens in patients without having an indication for chronic oral anticoagulation. " 05/26/2023 - "Although transcatheter aortic valve replacement (TAVR) is safe and effective, mortality and bleeding events post procedure are important. " 01/01/2023 - "The apparent sex paradox seen in women undergoing transcatheter aortic valve implantation refers to the phenomenon of women experiencing higher rates of short-term mortality and bleeding events, but demonstrating improved long-term survival as compared to men. " 02/01/2020 - "Despite the continuous improvement in operators' experience and techniques, and the development of new generation devices, thromboembolic and bleeding complications after transcatheter aortic valve implantation remain frequent, and are a major concern due to their negative impact on prognosis in this vulnerable population. " 11/01/2021 - "Academic Research Consortium High Bleeding Risk Criteria associated with 2-year bleeding events and mortality after transcatheter aortic valve replacement discharge: a Japanese Multicentre Prospective OCEAN-TAVI Registry Study."
5.	Bicuspid Aortic Valve Disease 03/01/2015 - "The purpose of this study is to evaluate the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with a severe stenotic bicuspid aortic valve (BAV) in a Chinese population. " 07/01/2022 - "Safety and efficacy of transcatheter aortic valve implantation in stenotic bicuspid aortic valve compared to tricuspid aortic valve: a systematic review and meta-analysis." 01/01/2022 - "We sought to conduct a systematic review and meta-analysis of clinical adverse events in patients undergoing transcatheter aortic valve replacement (TAVR) with bicuspid aortic valve (BAV) vs. tricuspid aortic valve (TAV) anatomy and the efficacy of balloon-expandable (BE) vs. self-expanding (SE) valves in the BAV population. " 03/24/2021 - "Objective: To evaluate the safety and efficacy of transcatheter aortic valve replacement (TAVR) with domestic prostheses in patients with severely stenotic bicuspid aortic valve (BAV). " 03/24/2021 - "[Evaluation of the safety and efficacy of transcatheter aortic valve replacement with domestic prostheses for patients with severely stenotic bicuspid aortic valve]."

Related Drugs and Biologics

1.	Vitamin K
2.	Anticoagulants
3.	Clopidogrel (Plavix)
4.	Brain Natriuretic Peptide (Natrecor)
5.	Ticagrelor
6.	von Willebrand Factor
7.	Troleandomycin (TAO)
8.	Protamines (Protamine Sulfate)
9.	Anti-Bacterial Agents (Antibiotics)
10.	remimazolam

Related Therapies and Procedures

1.	Therapeutics
2.	Bioprosthesis
3.	Transcatheter Aortic Valve Replacement
4.	Prostheses and Implants (Prosthesis)
5.	Percutaneous Coronary Intervention