Bradykinin B2 Receptor Antagonists

Compounds and drugs that inhibit ligand binding or cellular signaling by BRADYKININ B2 RECEPTORS.

Also Known As:

Bradykinin B2 Antagonists; Bradykinin B2 Receptor Blockers; Bradykinin B2 Receptor Inhibitors; Antagonists, Bradykinin B2; B2 Antagonists, Bradykinin

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Bradykinin Receptor Antagonists: 155
      - Bradykinin B2 Receptor Antagonists: 8
  - Physiological Effects of Drugs: 1
    - Immunologic Factors: 7984
      - Immunosuppressive Agents: 10145
        Complement Inactivating Agents: 474
        Bradykinin B2 Receptor Antagonists: 8

Experts

1.	Aquaro, Stefano: 1 article (10/2022)
2.	Catalano, Alessia: 1 article (10/2022)
3.	Ceramella, Jessica: 1 article (10/2022)
4.	Iacopetta, Domenico: 1 article (10/2022)
5.	Longo, Pasquale: 1 article (10/2022)
6.	Mariconda, Annaluisa: 1 article (10/2022)
7.	Pellegrino, Michele: 1 article (10/2022)
8.	Saturnino, Carmela: 1 article (10/2022)
9.	Sinicropi, Maria Stefania: 1 article (10/2022)
10.	Chapman, Richard W: 1 article (01/2021)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2005 - "Pharmacological studies using bradykinin B2 receptor antagonists suggest that bradykinin, an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is involved in secondary brain damage after cerebral ischemia. " 01/01/1999 - "The effects of several drugs (terfenadine, bradykinin B2 receptor antagonists: HOE 140, NPC 17731, diacerein, indomethacin, meloxicam, nabumetone, and dexamethasone) upon myeloperoxidase and nitrate levels were analyzed in an inflammation model characterized by biphasic peaks (4 and 48 h) of cell migration and of fluid leakage. "
2.	Brain Ischemia (Cerebral Ischemia) 08/01/2005 - "Pharmacological studies using bradykinin B2 receptor antagonists suggest that bradykinin, an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is involved in secondary brain damage after cerebral ischemia. "
3.	Angioedema 02/01/2020 - "There are no published guidelines for treating rtPA-induced orolingual angioedema, although some evidence suggests that those refractory to standard antianaphylactic agents may resolve with bradykinin B2 receptor antagonists. " 12/01/2015 - "The treatment of choice in angioedema including fresh frozen plasma, C1 inhibitor concentrations and BRK-2 antagonists (bradykinin B2 receptor antagonists) were used. In this case; a 77 years old female patient suffering from hypertension was considered. "
4.	Neurogenic Inflammation 11/20/1998 - "Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat."
5.	Pain (Aches) 01/01/2018 - "These findings suggest that the potential utility of bradykinin B2 receptor antagonists as a novel target for treating urogenital pain."

Related Drugs and Biologics

1.	Bradykinin
2.	Tachykinins
3.	Angiotensin Receptor Antagonists
4.	Cyclooxygenase Inhibitors
5.	Terfenadine (Seldane)
6.	Nitrates
7.	Peroxidase (Myeloperoxidase)
8.	Ligands
9.	Indomethacin (Indometacin)
10.	Immunologic Factors (Immunomodulators)

Related Therapies and Procedures

1.	Therapeutics