Gasotransmitters

Endogenously produced lipid-soluble gaseous molecules which function as neurotransmitters and signal mediators targeting ION CHANNELS and transporters.

Also Known As:

Gaseous Mediators; Gaseous Messenger Molecules; Gaseous Secondary Messengers; Gaseous Signal Transducers; Mediator, Gaseous; Mediators, Gaseous; Messenger Molecule, Gaseous; Messenger Molecules, Gaseous; Messenger, Gaseous Secondary; Messengers, Gaseous Secondary; Molecule, Gaseous Messenger; Molecules, Gaseous Messenger; Secondary Messenger, Gaseous; Secondary Messengers, Gaseous; Signal Transducer, Gaseous; Signal Transducers, Gaseous; Transducer, Gaseous Signal; Transducers, Gaseous Signal; Gaseous Mediator; Gaseous Messenger Molecule; Gaseous Secondary Messenger; Gaseous Signal Transducer; Gasotransmitter

Networked: 326 relevant articles (10 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yang, Guangdong: 9 articles (11/2021 - 11/2012)
2.	Wang, Rui: 8 articles (04/2015 - 02/2005)
3.	Kawabata, Atsufumi: 7 articles (02/2015 - 11/2007)
4.	Wu, Lingyun: 6 articles (01/2021 - 01/2011)
5.	Sekiguchi, Fumiko: 6 articles (02/2015 - 11/2007)
6.	Bhatia, Madhav: 5 articles (03/2022 - 04/2008)
7.	Calderone, Vincenzo: 5 articles (01/2022 - 01/2017)
8.	Martelli, Alma: 5 articles (01/2022 - 01/2017)
9.	Szabo, Csaba: 5 articles (01/2021 - 03/2013)
10.	Citi, Valentina: 4 articles (01/2022 - 01/2017)

Related Diseases

1.	Ischemia 01/01/2023 - "Hydrogen sulfide (H2S) is a gasotransmitter deeply involved in cardiovascular homeostasis and implicated in the myocardial protection against ischemia/reperfusion. " 12/20/2022 - "Deficient production of gasotransmitters has been linked to various diseases such as hypertension, endothelial dysfunction, myocardial infarction, ischemia, and impaired wound healing, as they are involved in the regulatory action of angiogenesis. " 11/30/2012 - "Hydrogen sulfide (H(2)S) has emerged as an important gasotransmitter, offering protection against ischemia-reperfusion damage to the heart. " 03/15/2018 - "Hydrogen sulfide is a gasotransmitter that mediates cardiovascular responses and could protect the heart from ischemia-reperfusion damage. " 06/16/2023 - "Low levels of gasotransmitters are often associated with specific problems or diseases, so NO, CO, and H2 S hold potential in treating bacterial infections, chronic wounds, myocardial infarction, ischemia, and various other diseases. "
2.	Traumatic Brain Injuries (Traumatic Brain Injury) 11/01/2017 - "A previous study from our group demonstrated that hydrogen sulfide (H2S), the third endogenous gaseous mediator identified, had protective effects against neuronal damage induced by traumatic brain injury (TBI). " 12/01/2019 - "Hydrogen sulfide as the third endogenous gaseous mediator had protective effects against traumatic brain injury-induced neuronal damage in mice. " 01/01/2020 - "Ever since endogenous hydrogen sulfide (H2S) was found in mammals in 1989, accumulated evidence has demonstrated that H2S functions as a novel neurological gasotransmitter in brain tissues and may play a key role in traumatic brain injury. "
3.	Inflammation (Inflammations) 08/01/2021 - "The interrelationship between gasotransmitters and oxidative stress, inflammation and apoptosis in lead-induced hepatotoxicity was investigated in this study. " 11/11/2023 - "Several molecular pathways have been identified as central players in vascular ageing, including oxidative stress and inflammation, the renin-angiotensin-aldosterone system, cellular senescence, macroautophagy, extracellular matrix remodelling, calcification, and gasotransmitter-related signalling. " 08/01/2021 - "The potential relationship between gasotransmitters and oxidative stress, inflammation and apoptosis in lead-induced hepatotoxicity in rats." 01/01/2021 - "The interrelationship of H2S with other gasotransmitters in inflammation will also be examined. " 01/01/2021 - "The mechanistic pathways regulated by H2S include but not limited to transcription, mRNA translation, signaling, inflammation, and oxidative stress demonstrating the versatility of the gasotransmitter. "
4.	Reperfusion Injury 08/05/2023 - "Among others, gaseous signaling molecules constitutively produced by mammalian cells (gasotransmitters) have been shown to be of potential interest for clinical treatment of ischemia/reperfusion injury. " 03/01/2015 - "The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning." 12/01/2011 - "Although several questions remain to be elucidated about the properties of this new gasotransmitter, increased H2S levels may have therapeutic potential in clinical settings in which ischemia/reperfusion injury is encountered. " 04/27/2011 - "Emergent role of gasotransmitters in ischemia-reperfusion injury." 12/01/2018 - "Hydrogen sulfide (H2S) has been recognized as an important gasotransmitter exerting potent cardioprotection from ischemia/reperfusion injury (I/R). "
5.	Wounds and Injuries (Trauma) 11/01/2017 - "This study aimed to examine the levels of three gasotransmitters in the early phase of trauma patients. " 01/01/2020 - "However, for non-healing wounds with heavy exudates, a wound dressing that can absorb wound exudates and controlled gasotransmitter release to improve the wound healing process is still in urgent need. " 08/12/2019 - "Antibacterial and Cellular Response Toward a Gasotransmitter-Based Hybrid Wound Dressing." 11/01/2017 - "The three gasotransmitters participated in systemic inflammatory responses during early trauma and could be used as important indicators for trauma severity. " 11/01/2017 - "The analysis on the expression of gasotransmitters in early trauma patients."

Related Drugs and Biologics

1.	Hydrogen Sulfide (Sulfide, Hydrogen)
2.	Lipids
3.	GYY 4137
4.	Hydrogen
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Cytokines
7.	Carbon Monoxide
8.	Enzymes
9.	Sulfides (Thioethers)
10.	Prodrugs

Related Therapies and Procedures

1.	Therapeutics
2.	Immunomodulation
3.	Investigational Therapies (Experimental Therapy)
4.	Intraperitoneal Injections
5.	Drug Therapy (Chemotherapy)