Sodium Channel Agonists

A class of drugs that stimulate sodium influx through cell membrane channels.

Also Known As:

Sodium Channel Activators; Sodium Channel Stimulators; Activators, Sodium Channel; Agonists, Sodium Channel; Channel Activators, Sodium; Channel Agonists, Sodium; Channel Stimulators, Sodium; Stimulators, Sodium Channel

Networked: 6 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Membrane Transport Modulators
      - Sodium Channel Agonists: 6
        Epithelial Sodium Channel Agonists
        Voltage-Gated Sodium Channel Agonists

Experts

1.	Alewood, Paul F: 1 article (10/2016)
2.	Baillie, Gregory J: 1 article (10/2016)
3.	Brust, Andreas: 1 article (10/2016)
4.	Bruxner, Timothy J C: 1 article (10/2016)
5.	Dashevsky, Daniel: 1 article (10/2016)
6.	Debono, Jordan: 1 article (10/2016)
7.	Deuis, Jennifer R: 1 article (10/2016)
8.	Dobson, James: 1 article (10/2016)
9.	Frank, Nathaniel: 1 article (10/2016)
10.	Fry, Bryan G: 1 article (10/2016)

Related Diseases

1.	Heart Failure 04/01/1991 - "We conclude that (1) sodium-channel activators may produce a significant cAMP-independent positive inotropic effect in left ventricular myocardium from failing human hearts; (2) the inotropic effect of sodium-channel activators were more potent and more effective in NYHA IV as compared to NYHA II-III. The degree of myocardial failure does not reduce the effectiveness of the sodium-channel activator BDF 9148."
2.	Neuroblastoma 11/01/1982 - "The effect of sodium channel activators on muscarinic receptors of neuroblastoma cells." 07/15/2005 - "Voltage-gated sodium channel-mediated (22)Na influx in a neuroblastoma cell line allowed assay of the effects of such sodium channel activators as batrachotoxin and a pumiliotoxin B/scorpion venom combination. "
3.	Ciguatera Poisoning (Ciguatera) 11/01/2005 - "Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators." 11/01/2005 - "The fact that 27 plant extracts were found to exert, in vitro, a protective effect against the action of ciguatoxin and/or brevetoxin, paves the way for finding new active compounds to treat ciguatera fish poisoning, provided these compounds also reverse the effects of sodium channel activators."
4.	Hyperalgesia 01/01/2014 - "Knockouts also showed no painful behaviors resulting from peripheral injection of nonselective sodium channel activators, did not develop complete Freund's adjuvant-induced thermal hyperalgesia, and were insensitive to intra-dermal histamine injection. "
5.	Bites and Stings (Sting) 10/18/2016 - "The Snake with the Scorpion's Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake (Calliophis bivirgatus)."

Related Drugs and Biologics

1.	Sodium Channels (Sodium Channel)
2.	BDF 9148
3.	Voltage-Gated Sodium Channels
4.	Venoms
5.	Scorpion Venoms (Scorpion Venom)
6.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
7.	Plant Extracts
8.	Histamine (Histamine Dihydrochloride)
9.	Freund's Adjuvant
10.	Ciguatoxins