Skin Lightening Preparations

Substances used to obtain a lighter skin complexion or to treat HYPERPIGMENTATION disorders.

Also Known As:

Depigmenting Agents; Skin Bleaching Agents; Skin Depigmenting Agents; Skin Whitening Agents; Agent, Depigmenting; Agent, Skin Bleaching; Agent, Skin Depigmenting; Agent, Skin Whitening; Agents, Depigmenting; Agents, Skin Bleaching; Agents, Skin Depigmenting; Agents, Skin Whitening; Bleaching Agent, Skin; Bleaching Agents, Skin; Depigmenting Agent; Depigmenting Agent, Skin; Depigmenting Agents, Skin; Lightening Preparation, Skin; Lightening Preparations, Skin; Preparation, Skin Lightening; Preparations, Skin Lightening; Skin Bleaching Agent; Skin Depigmenting Agent; Skin Lightening Preparation; Skin Whitening Agent; Whitening Agent, Skin; Whitening Agents, Skin

Networked: 119 relevant articles (13 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Youngsoo: 4 articles (01/2017 - 05/2002)
2.	Chang, Te-Sheng: 4 articles (01/2012 - 01/2011)
3.	Min, Kyung Rak: 3 articles (02/2006 - 05/2002)
4.	Passeron, Thierry: 2 articles (11/2022 - 11/2011)
5.	Ilic-Tomic, Tatjana: 2 articles (10/2021 - 12/2017)
6.	Pavic, Aleksandar: 2 articles (10/2021 - 12/2017)
7.	Matsunaga, Kayoko: 2 articles (07/2021 - 08/2014)
8.	Suzuki, Tamio: 2 articles (07/2021 - 08/2014)
9.	Goenka, Shilpi: 2 articles (06/2021 - 04/2020)
10.	Simon, Sanford R: 2 articles (06/2021 - 04/2020)

Related Diseases

1.	Melanosis (Freckles) 11/01/2011 - "This study suggests that Dermamelan produces significant rapid improvement of melasma at a clinical and cellular level and demonstrates the potential of RCM to monitor and possibly predict efficacy of a new depigmenting agent in the treatment of melasma." 07/01/2014 - "This study describes the first report of improvement in melasma through the combined use of monopolar RF with transdermal delivery of depigmenting agents. " 07/04/2022 - "Because recurrence is common in melasma, depigmenting agents should be used after all procedures." 09/01/2020 - "Reflectance Confocal Microscopy Assessment of the Depigmenting Agents Complex for Melasma Treatment." 11/01/2018 - "Understanding of naturally occurring depigmenting agents provides an opportunity for more effective ways to manage melasma in all skin types. "
2.	Hyperpigmentation 01/01/2011 - "From the present study, PAE is proven to be a good candidate as a skin-whitening agent for treatment of skin hyperpigmentation." 10/24/2023 - "Hyperpigmentation disorders causing emotional distress require the topical use of depigmenting agents of natural origin. " 10/01/2022 - "The review shows that these alternative depigmenting agents can be rationally combined to achieve desired treatment goals in the management of hyperpigmentation." 09/23/2021 - "Hyperpigmentation diseases of the skin require topical treatment with depigmenting agents. " 06/01/2021 - "In summary, our results demonstrate that CAS might hold promise as a depigmenting agent for hyperpigmentation disorders."
3.	Lentigo (Lentiginosis) 01/01/2015 - "Twenty patients with solar lentigines of the face and hands applied the depigmenting agent on each lentigo once daily for 12 weeks. " 12/01/2004 - "Skin hyperpigmentations such as melasma, freckles and senile lentigines can be subjectively treated by depigmenting agents. " 12/01/2021 - "A recent clinical trial has shown considerable efficacy of topical cysteamine for the treatment of senile lentigines, which are usually considered to be resistant to topical depigmenting agents. " 01/01/2015 - "Clinical and instrumental evaluation of the efficacy of a new depigmenting agent containing a combination of a retinoid, a phenolic agent and an antioxidant for the treatment of solar lentigines." 01/01/2015 - "To evaluate the efficacy and safety of a new depigmenting agent containing a retinoid (retinaldehyde), a new phenolic agent (4-(1-phenylethyl)-resorcinol) and a reducing agent (δ-tocopheryl-β-D-glucopyranoside) in the topical treatment of solar lentigines. "
4.	Neutropenia 12/15/2017 - "7C and 5,7C decreased the body pigmentation at 5 µg/mL, while did not affect the embryos development and survival at doses ≤50 µg/mL and ≤25 µg/mL. Unlike hydroquinone and kojic acid, 4-phenyl hydroxycoumarins were no melanocytotoxic, showed no cardiotoxic side effects, neither caused neutropenia in zebrafish embryos, suggesting these compounds may present novel skin-whitening agents with improved pharmacological properties. "
5.	Melanoma (Melanoma, Malignant) 06/21/2013 - "This study evaluated the effects of a hydroalcoholic extract of Garcinia gardneriana leaves (HEGG) on B16F10 murine melanoma cells in order to search for new depigmenting agents. " 10/01/1978 - "Depigmenting agents and melanoma." 01/01/1973 - "The effects of depigmenting agents on the growth of a transplantable hamster melanoma." 09/28/2023 - "To develop potential skin-whitening agents, we used B16F1 melanoma cells to investigate the inhibitory effects of anhydrous alum on melanogenesis and its underlying molecular mechanisms. " 06/01/2021 - "These results demonstrate that DPHC can effectively inhibit melanogenesis in melanoma cells in vitro and in zebrafish in vivo, suggesting that DPHC could be applied in fields of pharmaceutical and cosmeceuticals as a skin-whitening agent. "

Related Drugs and Biologics

1.	Cosmetics
2.	hydroquinone (Esoterica)
3.	Cysteamine (Mercaptamine)
4.	Retinoids
5.	kojic acid
6.	Chitosan
7.	Monophenol Monooxygenase (Tyrosinase)
8.	Melanins (Melanin)
9.	Enzymes
10.	Antioxidants

Related Therapies and Procedures

1.	Therapeutics
2.	Physical Therapy Modalities (Physical Therapy Technique)
3.	Laser Therapy (Surgery, Laser)
4.	Lasers (Laser)
5.	Immunotherapy