Coxa Vara

Hip deformity in which the femoral neck leans forward resulting in a decrease in the angle between femoral neck and its shaft. It may be congenital often syndromic, acquired, or developmental.

Also Known As:

Acquired Coxa Vara; Acquired Coxa Varus; Congenital Coxa Varus; Coxa Vara, Congenital; Coxa Varus; Developmental Coxa Vara; Developmental Coxa Varus; Infantile Coxa Vara; Acquired Coxa Varas; Congenital Coxa Varas; Coxa Vara, Acquired; Coxa Vara, Developmental; Coxa Vara, Infantile; Coxa Varas; Coxa Varas, Acquired; Coxa Varas, Congenital; Coxa Varas, Developmental; Coxa Varas, Infantile; Coxa Varus, Acquired; Coxa Varus, Congenital; Coxa Varus, Developmental; Developmental Coxa Varas; Infantile Coxa Varas; Vara, Coxa; Varas, Coxa; Varus, Coxa; Congenital Coxa Vara

Networked: 150 relevant articles (5 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Congenital Abnormalities (Deformity)
2.	Legg-Calve-Perthes Disease (Perthes Disease)
3.	Slipped Capital Femoral Epiphyses
4.	Pseudarthrosis (Pseudoarthrosis)
5.	Infectious Arthritis (Septic Arthritis)

Experts

1.	Mackenzie, William G: 3 articles (07/2019 - 06/2006)
2.	Al Kaissi, Ali: 3 articles (08/2018 - 06/2014)
3.	Grill, Franz: 3 articles (08/2018 - 06/2014)
4.	Kenis, Vladimir: 3 articles (08/2018 - 06/2014)
5.	Jay, Gregory D: 2 articles (04/2022 - 06/2017)
6.	Zhang, Ling X: 2 articles (04/2022 - 06/2017)
7.	Bober, Michael B: 2 articles (07/2019 - 09/2014)
8.	Ganger, Rudolf: 2 articles (08/2018 - 04/2016)
9.	Heimkes, Bernhard: 2 articles (06/2013 - 03/2009)
10.	Komm, Moritz: 2 articles (06/2013 - 03/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Coxa Vara:

1.	Proteoglycans (Proteoglycan)IBA 08/01/2014 - "Camptodactyly--arthropathy-coxa vara-pericarditis (CACP) syndrome is an autosomal recessive disorder caused by mutations in the PRG4 (proteoglycan 4) gene. " 02/01/2006 - "The camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is an autosomal recessive disorder caused by mutations in the PRG4 (Proteoglycan 4) gene. " 01/24/2023 - "Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the proteoglycan 4 (PRG4) gene, is characterized by early-onset camptodactyly, noninflammatory arthropathy, coxa vara deformity, and rarely, pericardial effusion. " 02/05/2017 - "Camptodactyly-arthropathy-coxa-vara-pericarditis (CACP) syndrome is an autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, the main lubricant for joints and tendon surfaces. " 02/01/2014 - "Camptodactyly-Arthropathy-Coxa vara-Pericarditis (CACP) syndrome is a rare autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, a mucin-like glycoprotein that is the major lubricant for joints and tendon surfaces. "
2.	LubricantsIBA 02/05/2017 - "Camptodactyly-arthropathy-coxa-vara-pericarditis (CACP) syndrome is an autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, the main lubricant for joints and tendon surfaces. " 02/01/2014 - "Camptodactyly-Arthropathy-Coxa vara-Pericarditis (CACP) syndrome is a rare autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, a mucin-like glycoprotein that is the major lubricant for joints and tendon surfaces. "
3.	SolutionsIBA 06/01/1982 - "[Close collaboration with paediatricians and aimed health education of parents--the key to the solution of the problem of coxa vara adolescentium]." 12/01/1983 - "[Southwick's osteotomy as a solution for cases of dislocated coxa vara in adolescence]."
4.	MetalsIBA 01/01/2022 - "Key words: coxa vara adolescentium, metal implants, migration." 01/01/2022 - "[Migration of the Tips of Metal Implants during Treatment of Coxa Vara Adolescentium (Slipped Capital Femoral Epiphysis)]." 07/01/2011 - "Six femoral fractures healed uneventfully, whilst the one with the 'floating knee' injury developed a delayed union postoperatively due to metal failure in 6 months, and, eventually, a malunion with coxa vara deformity 1.5 years later. "
5.	Glycoproteins (Glycoprotein)IBA 04/12/2022 - "Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4-PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. " 02/01/2014 - "Camptodactyly-Arthropathy-Coxa vara-Pericarditis (CACP) syndrome is a rare autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, a mucin-like glycoprotein that is the major lubricant for joints and tendon surfaces. "
6.	lubricinIBA 06/11/2017 - "These findings are relevant to patients at risk for arthrosis, from camptodactyl-arthropathy-coxa vara-pericarditis (CACP) syndrome and transient lubricin insufficiency due to trauma and inflammation." 04/12/2022 - "Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome leads to diarthrodial joint arthropathy and is caused by the absence of lubricin (proteoglycan 4-PRG4), a surface-active mucinous glycoprotein responsible for lubricating articular cartilage. "
7.	amsonic acid (DAS)IBA 12/01/2022 - "Die Dauer der konservativen Therapie ist verlängert und birgt das Risiko einer Pseudarthrose und der Entwicklung einer Coxa-vara-Deformität. " 10/01/2020 - "Das Phänomen des scheinbar (ver)doppelten Hüftkopfes wird verursacht durch das Überlappen des Trochanter major mit dem Femurkopf bei Coxa vara und verminderter Antetorsion. "
8.	Collagen Type II (Type II Collagen)IBA 01/01/2006 - "Spondyloepimetaphyseal dysplasia (SEMD) Strudwick type is a rare autosomal dominant condition arising from defects in COL2A1 the genes responsible for the biosynthesis of procollagen type II. The orthopaedic manifestations of patients can be hypoplastic odontoid peg with atlantoaxial instability, severe kyphosis or lordosis of dorsal and lumbar spines, hip subluxation, coxa vara and early severe hip osteoarthritis, and malalignment of lower limbs like genu valgum or club foot. "
9.	MucinsIBA 02/01/2014 - "Camptodactyly-Arthropathy-Coxa vara-Pericarditis (CACP) syndrome is a rare autosomal recessive disorder caused by mutations in PRG4 gene that encodes for proteoglycan 4, a mucin-like glycoprotein that is the major lubricant for joints and tendon surfaces. "
10.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 12/01/2021 - "HPP associated with bony abnormalities in form of spontaneous atypical fractures in femoral shaft with coxa vara is an unusual presentation. "

Therapies and Procedures

1.	Osteotomy 06/01/2013 - "The articulotrochanteric distance was 5 mm/26 mm/14 mm. The subtrochanteric end-to-side valgization osteotomy showed to be highly effective in the management of the infantile coxa vara, improving the clinical impairment of the patients postoperatively. " 12/01/2017 - "Clinical results were markedly improved by the osteotomy, with a mean postoperative Iowa Hip Score at last follow-up of 95.06 ± 2.6, compared to a mean preoperative score of 57.4 ± 3.6. Transfixing wires protected in a hip spica cast represent a simple, easy, and reliable fixation method for valgus osteotomies performed to correct pediatic coxa vara. " 11/01/2013 - "Minimal access surgery using external fixation for a valgus osteotomy of the proximal femur is safe and effective for the treatment for coxa vara and limb length discrepancy. " 07/01/2011 - "Valgus subtrochanteric osteotomy is the gold standard surgical treatment of developmental coxa vara. " 09/01/2011 - "The purpose of this study was to investigate the effect of valgus intertrochanteric osteotomy in patients with coxa vara older than 30 years. "
2.	External Fixators 10/01/2008 - "Two head automatic new type pressure external fixator can embed more tightly without sliding, also can prevent the occurrence of coxa vara effectively." 11/01/2013 - "In this study, 9 hips in 9 patients with the diagnosis of developmental coxa vara underwent a subtrochanteric osteotomy with stabilization by an external fixator. " 07/01/2017 - "Recently, good results have been reported using external fixator systems for the correction of proximal femoral deformities secondary to slipped capital femoral epiphysis, Perthes' disease in children, and percutaneous proximal femoral osteotomy for coxa vara. "
3.	Hemiarthroplasty 01/01/2022 - "Our study proved that it is sometimes hard to achieve femoral offset within a safe range while performing hip hemiarthroplasty in patients with coxa vara. "
4.	Therapeutics 08/01/1973 - "[Coxa vara adolescentium--results of therapy (author's transl)]." 07/01/1972 - "[Etiology and therapy of congenital coxa vara]." 01/01/1954 - "[Resection of trochanter as a physiological therapy of coxa vara]." 08/01/1953 - "[Therapy of coxa vara of adolescents]." 01/01/1952 - "[Therapy of coxa vara adolescentium]."
5.	Hip Replacement Arthroplasty (Total Hip Replacement) 01/01/2021 - "We aimed to demonstrate the methods of treatment for coxa vara with modular total hip arthroplasty (THA) and evaluate clinical and radiographic outcomes, and further survivorship at the midterm follow-up. " 10/15/2019 - "Reasons for failure of internal fixation: ① There were 8 cases of coxa varus at 12 weeks after operation due to the loss of posteromedial cortex of femoral intertrochanteric, 7 of them continued non-weight-bearing observation and fracture healed at 6 months after operation; 1 case underwent total hip arthroplasty with spiral blade excision after operation. " 01/01/2017 - "In total hip arthroplasty (THA) of hips with coxa vara, the femoral stems might be inserted in a varus alignment. " 01/01/2022 - "We obtained femoral neck specimens of 28 osteoarthritic human subjects with coxa vara, coxa norma and coxa valga during total hip arthroplasty. " 01/01/2021 - "Treatment of Osteoarthritis Secondary to Severe Coxa Vara with Modular Total Hip Arthroplasty."