Ophthalmoplegic Migraine

Childhood-onset of recurrent headaches with an oculomotor cranial nerve palsy. Typically, ABDUCENS NERVE; OCULOMOTOR NERVE; and TROCHLEAR NERVE are involved with DIPLOPIA and BLEPHAROPTOSIS.

Also Known As:

Ophthalmoplegic Migraine Syndrome; Migraine Syndrome, Ophthalmoplegic; Migraine Syndromes, Ophthalmoplegic; Migraine, Ophthalmoplegic; Migraines, Ophthalmoplegic; Ophthalmoplegic Migraine Syndromes; Ophthalmoplegic Migraines; Syndrome, Ophthalmoplegic Migraine; Syndromes, Ophthalmoplegic Migraine

Networked: 35 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abducens Nerve Diseases (Sixth Nerve Palsy)
2.	Strabismus (Squint)
3.	Migraine Disorders (Migraine)
4.	Migraine with Aura (Familial Hemiplegic Migraine)
5.	Headache (Headaches)

Experts

1.	Abe, Takanori: 2 articles (02/2009 - 08/2007)
2.	Manabe, Tetsuya: 2 articles (02/2009 - 08/2007)
3.	Ogose, Takeshi: 2 articles (02/2009 - 08/2007)
4.	Caplan, Louis: 1 article (06/2019)
5.	Lal, Vivek: 1 article (06/2019)
6.	Haan, Joost: 1 article (01/2019)
7.	van Dongen, Robin M: 1 article (01/2019)
8.	Abo-Shasha, Rami: 1 article (10/2018)
9.	Bauman, Glenn S: 1 article (10/2018)
10.	Fraser, J Alexander: 1 article (10/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ophthalmoplegic Migraine:

1.	Botulinum Toxins (Botulinum Toxin)IBA 03/01/2007 - "Both botulinum toxin and squint surgery may be useful in the management of longstanding sixth nerve palsy in patients with ophthalmoplegic migraine. "
2.	SteroidsIBA 07/01/1997 - "We suggest that a positive MRI finding can be included as one of the diagnostic criteria in the classification of ophthalmoplegic migraine and that a trial of steroid is worthwhile in the presence of enhancement of the oculomotor nerve since ophthalmoplegic migraine may be noninfectious but inflammatory in etiology." 01/01/2011 - "Childhood steroid-responsive ophthalmoplegic migraine." 10/01/2001 - "Patients with ophthalmoplegic migraine may, therefore, benefit from the use of steroids. " 08/01/2007 - "Childhood steroid-responsive painful ophthalmoplegia: clues to ophthalmoplegic migraine."
3.	FenamatesIBA 01/01/1977 - "Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. "
4.	Prostaglandin Antagonists (Prostaglandin Antagonist)IBA 01/01/1977 - "Ophthalmoplegic migraine: amelioration by Flufenamic acid, a prostaglandin inhibitor." 01/01/1977 - "Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. "
5.	Flufenamic AcidIBA 01/01/1977 - "Ophthalmoplegic migraine: amelioration by Flufenamic acid, a prostaglandin inhibitor." 01/01/1977 - "Based on this hypothesis a therapeutic trial with flufenamic acid (a prostaglandin inhibitor of the fenamates group) was conducted during 1 year in 5 patients suffering from recurrent ophthalmoplegic migraine. "
6.	Retinaldehyde (Retinal)IBA 01/01/2007 - "There is no doubt that ocular migraine also known as retinal migraine or ophthalmic migraine should not to be confused with ophthalmoplegic migraine. " 01/01/2013 - "These include hemiplegic migraine, basilar-type migraine, childhood periodic syndromes, retinal migraine, complicated migraine, ophthalmoplegic migraine and vertiginous migraine. " 04/01/2010 - "These include hemiplegic migraine, basilar migraine, childhood periodic syndromes, retinal migraine, complicated migraine and ophthalmoplegic migraine. " 01/01/2000 - "These syndromes include basilar migraine, familial hemiplegic migraine, ophthalmoplegic migraine and the exceptional retinal migraine. " 12/01/1997 - "In our review we emphasize their infrequency (ophthalmoplegic migraine, 0.7 per million; retinal migraine 0.5-7% of migraines with aura), their uncertain pathophysiology and the possibility of causing permanent oculomotor or visual deficits. "
7.	GadoliniumIBA 06/01/2019 - "The 3rd edition of the International Classification of Headache Disorders replaced the term ophthalmoplegic migraine (OM) with Recurrent Painful Ophthalmoplegic Neuropathy (RPON) based on the presence of contrast enhancement of the involved cranial nerves on Gadolinium-enhanced magnetic resonance imaging. " 05/01/2007 - "We describe a patient with ophthalmoplegic migraine and internal ophthalmoplegia with alternating unilateral involvement and bilateral involvement in whom brain MRI scan showed alternating gadolinium enhancement on the cisternal portion of the oculomotor nerve." 02/01/2002 - "We describe a patient with ophthalmoplegic migraine and right abducens nerve palsy, in whom serial magnetic resonance imaging showed a transient, gadolinium-enhancing lesion in the right lower pons, during both headache and the headache-free period. "
8.	Gadolinium DTPA (Magnevist)FDA Link 01/01/1999 - "[A case of ophthalmoplegic migraine: swelling and Gd-DTPA enhancement of the oculomotor nerve on MRI]." 10/01/2001 - "To present 2 children with ophthalmoplegic migraine and characteristic magnetic resonance imaging (MRI) findings post enhancement with gadopentetate dimeglumine diethylenetriamine pentaacetic acid (Gd-DTPA). "
9.	Indomethacin (Indometacin)FDA LinkGeneric 01/01/2015 - "Case reports of other primary headache disorders that also respond to indomethacin, such as cluster headache, nummular headache, and ophthalmoplegic migraine, have been described. " 06/01/2010 - "Two patients suffering from ophthalmoplegic migraine had a strictly unilateral headache absolutely responsive to indomethacin, but not to other non-steroidal anti-inflammatory drugs, analgesics or corticosteroids. "
10.	Nicorandil (SG 75)IBA 06/01/2012 - "Nicorandil induced ophthalmoplegic migraine."

Therapies and Procedures

1.	Therapeutics 05/01/1990 - "The infants with ophthalmoplegic migraine failed to completely respond to any therapy. "
2.	Radiotherapy 10/01/2018 - "Stereotactic radiotherapy for presumed oculomotor nerve schwannoma masquerading as "ophthalmoplegic migraine"."
3.	Adrenalectomy 11/01/1972 - "[Ophthalmoplegic migraine following total adrenalectomy for Itsenko-Cushing disease]."