Ketol-Acid Reductoisomerase

An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.

Also Known As:

Acetohydroxy Acid Isomeroreductase; Alpha-Acetohydroxyacid Isomeroreductase; Dihydroxyisovalerate Dehydrogenase (Isomerizing); Hydroxyacid Reductoisomerase; Isomeroreductase; Acid Isomeroreductase, Acetohydroxy; Alpha Acetohydroxyacid Isomeroreductase; Isomeroreductase, Acetohydroxy Acid; Isomeroreductase, Alpha-Acetohydroxyacid; Ketol Acid Reductoisomerase; Reductoisomerase, Hydroxyacid; Reductoisomerase, Ketol-Acid

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Ketol-Acid Reductoisomerase: 1

Experts

1.	Bayaraa, Tenuun: 1 article (07/2020)
2.	Bilyj, Jessica K: 1 article (07/2020)
3.	Guddat, Luke W: 1 article (07/2020)
4.	Hussein, Waleed M: 1 article (07/2020)
5.	Kurz, Julia L: 1 article (07/2020)
6.	McGeary, Ross P: 1 article (07/2020)
7.	Patel, Khushboo M: 1 article (07/2020)
8.	Schenk, Gerhard: 1 article (07/2020)
9.	West, Nicholas P: 1 article (07/2020)

Related Diseases

1.	Bacterial Infections (Bacterial Infection) 07/22/2020 - "Ketol-acid reductoisomerase (KARI), the second enzyme in the branched-chain amino acid biosynthesis pathway, is a potential drug target for bacterial infections including Mycobacterium tuberculosis. "

Related Drugs and Biologics

1.	Enzymes
2.	Branched-Chain Amino Acids