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Acute-Phase Proteins (Acute-Phase Protein)

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Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

Also Known As:

Acute-Phase Protein; Glycoproteins, Acute-Phase; Acute-Phase Glycoproteins; Acute Phase Glycoproteins; Acute Phase Protein; Acute Phase Proteins; Acute Phase Reactants; Protein, Acute-Phase; Proteins, Acute Phase; Reactants, Acute Phase; Acute-Phase Reactants; Proteins, Acute-Phase; Reactants, Acute-Phase

Networked: 2783 relevant articles (39 outcomes, 271 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Eckersall, P D: 8 articles (08/2012 - 01/2001)
2.	Herndon, David N: 7 articles (01/2012 - 04/2003)
3.	Koenig, Wolfgang: 6 articles (08/2009 - 11/2002)
4.	Kaysen, George A: 6 articles (01/2006 - 01/2003)
5.	Tremoli, Elena: 5 articles (07/2010 - 10/2004)
6.	Cerón, J J: 4 articles (08/2012 - 02/2002)
7.	Heegaard, Peter M H: 4 articles (05/2011 - 03/2009)
8.	Trayhurn, Paul: 4 articles (07/2010 - 09/2004)
9.	Sironi, Luigi: 4 articles (07/2010 - 10/2004)
10.	Guerrini, Uliano: 4 articles (07/2010 - 10/2004)

Related Diseases

1.	Inflammation 01/01/1996 - "The LAA test is superior to other acute phase reactants used in daily practice to detect the presence of inflammation as well as for the assessment of its severity in adolescent patients with IBD. " 01/01/2002 - "In addition, markers of inflammation and acute-phase reactants were measured in order to compare activity during active disease and during remission. " 06/01/2009 - "Recent studies have revealed homeostatic roles of vascular inflammation and have identified the action of humoral innate immunity, in particular injury-associated signals and acute phase proteins, on the activation of circulating leucocytes, platelets and endothelial cells. " 04/01/1998 - "This last finding indicates that the mouse is not suitable as a model for the study of those phenomena related to inflammation in humans, in which glycosylation of acute phase proteins could play a significant role." 09/01/1994 - "The study of markers of inflammation (acute phase proteins, leucocytes and platelets) demonstrated that the fluke had a modulating effect on the rat's inflammatory response. " Order ALL the reference details at left...
2.	Neoplasms (Cancer) 01/01/2004 - "It is a stimulus for search of other biochemical indicators, among others determinations of acute phase proteins, helpful in head and neck cancers diagnostics and prognosis. " 04/01/2010 - "However, further studies are required to define the potential clinical application of these acute-phase protein cancer-specific modifications as possible cancer diagnostic or monitoring tools." 01/01/2009 - "In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer. " 12/01/1993 - "This study has evaluated the relationship between tumor growth and induction of acute-phase proteins. " 01/01/1989 - "The study of the response of MLTs to specific acute-phase stimuli may make possible a better understanding of the basis for coordinated expression of acute-phase reactants and of the variable phenotypes associated with cancers." Order ALL the reference details at left...
3.	Arthritis (Polyarthritis) 11/01/1980 - "Thus, spontaneous remission of 6-SAI arthritis occurring, despite continued administration of 6-SAI, seems hardly likely to be caused by acute-phase reactants, e.g. " 03/01/2007 - "Traditionally, clinical trials for inflammatory arthritis have used composite response indices such as American College of Rheumatology response or improvement in Disease Activity Score as outcomes based on multiple joint clinical measures, acute phase reactants, and functional status. " 03/01/2005 - "MRA abruptly reduced disease activity in 10 of the 11 children, as assessed by the occurrence of febrile episodes, active arthritis, scores on the Childhood Health Assessment Questionnaire, and levels of acute-phase reactants. " 05/01/2012 - "Increased acute phase reactants, presence of peripheral arthritis, and male sex were repeatedly identified as independent baseline predictors of anti-TNF-α treatment continuation. " 03/01/2011 - "The role of acute-phase reactants in diagnosing and predicting outcome in patients presenting with undifferentiated arthritis is limited." Order ALL the reference details at left...
4.	Infection 09/28/2011 - "In the present study, acute phase proteins (APP) responses in pigs after infection with toxigenic strain of Pasteurella multocida (Pm) were evaluated. " 01/01/2001 - "Several recent studies have elevated the role of acute phase proteins (APPs) as predictive markers in infection. " 06/01/1999 - "Although several studies have shown that asymptomatic human immunodeficiency virus infection elicits an increase in whole body protein turnover, it is not known whether this increased protein turnover includes changes in the kinetics of acute-phase proteins (APPs). " 09/01/1994 - "A weekly study of various inflammatory markers (acute phase proteins, leucocytes and platelets) demonstrated that no inflammatory reaction had occurred after the first two weeks of infection, but that there was a significant increase in acute phase proteins after three and four weeks. " 01/01/1988 - "This study indicates that the concentrations of albumin and RBP along with selected acute phase reactants are rapidly influenced by altered nutritional status in children with undue susceptibility to acute infections." Order ALL the reference details at left...
5.	Rheumatoid Arthritis 01/01/1995 - "Do changes in clinical improvement in rheumatoid arthritis patients treated with immunosuppressive drugs reflect the changes in acute phase proteins?" 01/01/2010 - "The aim of this study was to assess the relationship between serum acute-phase proteins and high disease activity evaluated by activity score (DAS28) in patients with rheumatoid arthritis. " 01/01/2009 - "The paper presents the results of studies of acute phase reactants in the 60 treated patients with rheumatoid arthritis. " 01/01/1999 - "The purpose of the study was the evaluation of the effects of the combined therapy and non steroidal anti-inflammatory drugs on the acute phase reactants and clinical symptoms in patients with rheumatoid arthritis. " 01/01/2011 - "In terms of its relationship with acute-phase reactants, there are conflicting results in patients with rheumatoid arthritis (RA). " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	C-Reactive Protein
3.	Cytokines
4.	Fibrinogen (Factor I)
5.	Interleukin-1 (Interleukin 1)
6.	Serum Amyloid A Protein (Serum Amyloid A)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Blood Proteins (Serum Proteins)
9.	Immunoglobulins (Immunoglobulin)
10.	Trypsin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Renal Dialysis (Hemodialysis)
3.	Radiotherapy
4.	Transplantation (Transplant Recipients)
5.	Drug Therapy (Chemotherapy)

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