NF-kappaB-Inducing Kinase

A protein serine-threonine kinase that catalyzes the activation of canonical and non-canonical NF-kappaB pathways.

Also Known As:

B Kinase, NF-kappa; Kinase, MAP3K14; Kinase, NF-kappa B; Kinase, NF-kappaB-Inducing; Kinase, NFkB; Mitogen Activated Protein Kinase Kinase Kinase 14; NF kappa B Kinase; NF kappaB Inducing Kinase; Protein, NIK; MAP3K14 Kinase; Mitogen-Activated Protein Kinase Kinase Kinase 14; NF-kappa B Kinase; NF-kappa-B-Inducing Kinase (NIK); NFkB Kinase; NIK Protein; Nuclear Factor kappa B Kinase

Networked: 94 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Y: 3 articles (10/2021 - 01/2017)
2.	Maldonado, Vilma: 3 articles (01/2019 - 11/2016)
3.	Melendez-Zajgla, Jorge: 3 articles (01/2019 - 11/2016)
4.	Vazquez-Santillan, Karla: 3 articles (01/2019 - 11/2016)
5.	Dhawan, Punita: 3 articles (05/2008 - 03/2002)
6.	Richmond, Ann: 3 articles (05/2008 - 03/2002)
7.	Chen, X: 2 articles (05/2022 - 01/2017)
8.	Guo, G: 2 articles (05/2022 - 08/2020)
9.	Huang, Q: 2 articles (05/2022 - 08/2020)
10.	Liu, Y: 2 articles (05/2022 - 08/2020)

Related Diseases

1.	Necrosis 09/15/2000 - "The present study explores the uncharacterized signalling pathways employed by CD40 in activating NF-kappaB by the overexpression of genes encoding wild-type and dominant-negative forms of the signalling components tumour-necrosis-factor-receptor-associated factor 6 (TRAF-6), NF-kappaB-inducing kinase (NIK), IkappaB kinase (IKK)-1 and IKK-2 in the BJAB B-cell line. " 09/15/2000 - "Tumour-necrosis-factor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40." 02/01/2006 - "Co-expression of IkappaB alpha, IkappaB beta, IkappaB kinase (IKK)alpha, IKKbeta, IKKgamma, nuclear factor (NF)-kappaB-inducing kinase and tumour necrosis factor receptor-associated factor 2 dominant-negative constructs with LMP-1 inhibited the activation of the CCL20 promoter by LMP-1, suggesting that LMP-1 induces CCL20 via NF-kappaB signalling. " 10/01/2021 - "This was followed by investigating myeloid differentiation primary response 88 (MyD88), C-C motif chemokine ligand 5 (CCL5), melanoma differentiation-associated protein 5 (MDA5), the inhibitor of nuclear factor-kappa B kinase subunit epsilon (IKBKE), NF-κB inhibitor alpha (NFKBIA), NF-κB inhibitor epsilon (NFKBIE), interferon-alpha (IFN-α), colony-stimulating factor 3 (CSF3) and tumour necrosis factor receptor-associated factor 6 (TRAF6) by mRNA expression using quantitative real-time PCR (qRT-PCR) at four different time intervals (0, 2, 6 and 10 h).3. There was a significant interaction between erythrocytes and LPAIV H9N2 virus. "
2.	Rheumatoid Arthritis 01/01/2022 - "The Inhibitor of IKK-β (nuclear factor kappa B kinase subunit beta), a specific modulator of NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for various cancers and rheumatoid arthritis treatment. " 02/01/2019 - "Inhibitor of nuclear factor kappa B kinase subunit beta (IKK-β), a specific regulator of nuclear factor-κB (NF-κB), is considered a valid target to design novel candidate drugs to treat rheumatoid arthritis and various cancers. " 01/01/2018 - "The purpose of this study is to investigate the therapeutic effects and main mechanism of IKKε (inhibitor of nuclear factor kappa-B kinase ε) in collagen II induced- Rheumatoid Arthritis (CIA) mice model. "
3.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 05/15/2008 - "Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells." 05/15/2008 - "In our current study, we now report that NF-kappaB-inducing kinase (NIK) is overexpressed at the pretranslational level in adult T-cell leukemia (ATL) and Hodgkin Reed-Sternberg cells (H-RS) that do not express viral regulatory proteins. "
4.	Lung Neoplasms (Lung Cancer) 08/13/2020 - "Based on previous studies showing that KRAS activates nuclear factor kappa-B (NF-κB) through inhibitor of nuclear factor kappa-B kinase β (IKKβ) to promote lung tumourigenesis, we hypothesized that inhibition of IKKβ would reduce stemness, migration and invasion of KRAS-mutant human lung cancer cells. "
5.	Severe Fever with Thrombocytopenia Syndrome 01/01/2019 - "Our previous studies have shown that the nonstructural protein (NSs) of the severe fever with thrombocytopenia syndrome virus (SFTSV) can suppress the IFN-β induction through its interaction with tank-binding kinase-1 and sequestering the inhibitor of nuclear factor kappa B kinase(IKK) complex into the inclusion bodies formed by NSs. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Proteins (Proteins, Gene)
3.	I-kappa B Kinase
4.	Viral Regulatory and Accessory Proteins
5.	Therapeutic Uses
6.	Collagen
7.	Phosphotransferases (Kinase)
8.	JNK Mitogen-Activated Protein Kinases
9.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Gastric Bypass (Roux-en-Y Gastric Bypass)