Nociceptin

01/01/2020 - "Our study suggests that the serotonergic and nociceptin systems are associated with the activity of a cortico-subcortical brain network underlying the perception of mental pain during depression. "
01/28/2008 - "The aim of the present study was to clarify the role of nociceptin system in pain modulation. "
09/16/2002 - "This study aimed to define the change of serum level of nociceptin in pain patients. "
06/22/2001 - "The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. "
01/05/2001 - "The aim of the present study was to examine the effect of microinjection of orphanin FQ (OFQ) into periaqueductal gray (PAG) on sensory processing in the wide dynamic range (WDR) neurons of the spinal dorsal horn and to explore the effect of OFQ on a descending system of pain modulation. "

11/01/1999 - "Nociceptin (3.0 fmol) produced a significant reduction in the nociceptive thermal threshold (hyperalgesia) measured as the tail-flick and paw-withdrawal responses. "
04/18/1997 - "In the present study, we investigated the effect of intrathecally administered nociceptin on the level of thermal hyperalgesia induced by carageenan injection in the rat. "
01/08/2008 - "These results suggest that the spinal nociceptin system is involved in the transitional process from herpetic allodynia to postherpetic allodynia."
07/01/2004 - "Although hyperalgesia was fully present after 5 days, no changes in nociceptin immunoreactivity in the lumbar spinal cord were detected at this time point. "
12/01/2002 - "The supraspinal administration of nociceptin produces hyperalgesia. "

07/01/2015 - "Dysregulation of the nociceptin (N/OFQ) system has been implicated in alcohol abuse and alcoholism, and growing evidence suggests that targeting this system may be beneficial for treating alcoholism. "
10/01/2016 - "The nociceptin/orphanin FQ receptor agonist SR-8993 as a candidate therapeutic for alcohol use disorders: validation in rat models."
11/15/2018 - "Novel In Vivo Investigation of the Brain Nociceptin/Orphanin FQ System in Alcohol Use Disorder: Are There Lessons From a Negative Neuroimaging Study?"
11/15/2018 - "However, this finding does not necessarily rule out alterations in nociceptin transmission in alcohol dependence."
10/01/2014 - "Since its discovery, the nociceptin/orphanin FQ (N/OFQ)-NOP receptor system has been extensively investigated as a promising target to treat alcoholism. "

06/01/1998 - "Peripheral inflammation and nerve injury may induce spinal plasticity which leads to altered potency and efficacy of nociceptin."
01/01/2001 - "The present study investigates the effect of nociceptin on synovial plasma extravasation and its ability to modulate 5-hydroxytryptamine-induced synovial plasma extravasation using the rat knee joint model of inflammation. "
11/01/2009 - "Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation."
07/01/2001 - "The results suggest that peripheral inflammation induces the production of nociceptin in a sub-population of VR1-positive primary sensory neurons and support the idea that nociceptin produced there is involved in the regulation of nociceptive processing."
04/01/2000 - "This increased potency of nociceptin after inflammation is consistent with an increased receptor density in the superficial spinal cord. "

11/01/2014 - "Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system."
01/01/2023 - "In vitro sepsis up-regulates Nociceptin/Orphanin FQ receptor expression and function on human T- but not B-cells."
01/01/2022 - "In vitro sepsis induces Nociceptin/Orphanin FQ receptor (NOP) expression in primary human vascular endothelial but not smooth muscle cells."
10/01/2014 - "This review details the known effects of NOP activation on leucocytes and the vascular endothelium and discusses the most recent human and animal data on the role of the nociceptin system in sepsis. "
10/01/2014 - "Nociceptin system as a target in sepsis?"