Low Anterior Resection Syndrome

Postoperative complication after removal of the RECTUM (low anterior resection surgery or resection surgery to the lower part of the COLON). It includes disordered rectum function, e.g., frequent BOWEL MOVEMENT; FECAL INCONTINENCE; and CONSTIPATION.

Networked: 92 relevant articles (9 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fecal Incontinence
2.	Constipation
3.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
4.	Diarrhea
5.	Rectal Neoplasms (Rectal Cancer)

Experts

1.	Boutros, Marylise: 3 articles (08/2022 - 01/2020)
2.	Garfinkle, Richard: 3 articles (08/2022 - 01/2020)
3.	Dou, Ruoxu: 3 articles (03/2022 - 03/2019)
4.	Kang, Liang: 3 articles (03/2022 - 03/2019)
5.	Sun, Weipeng: 3 articles (03/2022 - 03/2019)
6.	Belgian LARS collaborative group: 2 articles (06/2022 - 03/2022)
7.	Gong, H F: 2 articles (04/2022 - 10/2020)
8.	Lou, Z: 2 articles (04/2022 - 10/2020)
9.	Meng, R G: 2 articles (04/2022 - 10/2020)
10.	Yu, G Y: 2 articles (04/2022 - 10/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Low Anterior Resection Syndrome:

1.	ramosetron (Nasea)IBA 01/01/2023 - "Transanal irrigation was associated with improvement in low anterior resection syndrome according to 2 trials, and ramosetron showed promising short-term results in one trial. " 01/01/2023 - "Ramosetron was associated with a greater short-term improvement in major low anterior resection syndrome (23% vs 8%) and a lower low anterior resection syndrome score (29.5 vs 34.6) at 4-weeks follow-up than Kegels or Sitz baths. "
2.	Serotonin 5-HT3 Receptor AntagonistsIBA 01/01/2014 - "These results suggest that 5-HT3 antagonists are effective for the treatment of low anterior resection syndrome, as in diarrhea-predominant irritable bowel syndrome. "
3.	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 01/01/2014 - "We investigated the efficacy of 5-HT3 receptor antagonists in patients suffering from severe low anterior resection syndrome. "
4.	Ondansetron (Zofran)FDA LinkGeneric 07/13/2023 - "Ondansetron for Low Anterior Resection Syndrome (LARS): A Double Blind, Placebo Controlled, Cross-Over, Randomized Study."
5.	MelatoninIBA 11/01/2023 - "Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial."
6.	Loperamide (Imodium)FDA LinkGeneric 01/01/2023 - "The aim of this study was to prospectively evaluate the effectiveness of combined pelvic floor muscle exercises (PFMEs) and loperamide treatment on rectal function and mental health for low anterior resection syndrome (LARS) patients after sphincter-saving operation (SSO) for rectal cancer. "
7.	Leukocyte L1 Antigen Complex (Calgranulin)IBA 08/01/2022 - "Calprotectin in Low anterior resection syndrome patients; a new insight into diagnosis and management: A pilot study."
8.	SolutionsIBA 07/28/2023 - "Neither technique appears to proffer solution to low anterior resection syndrome in the short term but future well-designed; high-quality RCTs with long term follow-up are required."
9.	Serotonin (5 Hydroxytryptamine)IBA 01/01/2014 - "Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome."
10.	omega-Chloroacetophenone (Mace)IBA 01/01/2022 - "Low anterior resection syndrome score was lower in the ISR plus MACE group than the ISR group (P=0.030). "

Therapies and Procedures

1.	Psychology Biofeedback (Biofeedback) 08/13/2019 - "Biofeedback training combined with pelvic floor muscle exercise reduced the incidence of low anterior resection syndrome of rectum (P<0.05). " 08/01/2020 - "Reply on "Efficacy of biofeedback therapy for objective improvement of pelvic function in low anterior resection syndrome (Ann Surg Treat Res 2019;97:194-201)"." 08/01/2020 - "Commentary on "Efficacy of biofeedback therapy for objective improvement of pelvic function in low anterior resection syndrome (Ann Surg Treat Res 2019;97:194-201)"." 10/01/2019 - "Efficacy of biofeedback therapy for objective improvement of pelvic function in low anterior resection syndrome." 01/01/2020 - "Rehabilitation program for patients with low anterior resection syndrome should include: 1) biofeedback therapy to improve the holding function; 2) biofeedback therapy aimed at improving the reservoir function and sensitivity of the rectum to filling; 3) tibial neuromodulation. "
2.	Therapeutics 12/01/2020 - "Randomized Pilot Trial of Percutaneous Posterior Tibial Nerve Stimulation Versus Medical Therapy for the Treatment of Low Anterior Resection Syndrome: One-Year Follow-up." 01/01/2023 - "In daily practice, the presentation, recording, prophylaxis and therapy of the low anterior resection syndrome (LARS) are of great importance for patients, relatives, therapists, service providers and cost bearers. " 01/01/2020 - "The predictive factors of success of endoluminal vacuum therapy and long-term functional result (low anterior resection syndrome score) were also analyzed. " 08/01/2019 - "[Low Anterior Resection Syndrome - Diagnosis - Therapy - Prophylaxis]." 01/01/2019 - "Randomized clinical trial of prophylactic transanal irrigation versus supportive therapy to prevent symptoms of low anterior resection syndrome after rectal resection."
3.	Ileostomy 01/01/2023 - "Wexner incontinence score and Kirwan's incontinence score significantly improved at 12 months after ileostomy reversal, but such improvement in low anterior resection syndrome score was proved until 24 months later ( p = 0.01). " 10/01/2022 - "In this first large-scale study assessing long-term function after anterior resection and reversal of ileostomy, there is a linear improvement in major low anterior resection syndrome beyond 6 years, alongside improvements in key quality-of-life measures. " 10/01/2022 - "The purpose of this study was to assess the impact of anterior resection and reversal of ileostomy on long-term health-related quality of life and low anterior resection syndrome. " 11/01/2023 - "Two years after ileostomy closure, 52.7% of patients in the SCAA group were assessed as having major low anterior resection syndrome (LARS), which was significantly higher than the 25.9% of patients in the TCP group (P = 0.014), but no difference was found prior to 2 years. " 10/31/2023 - "The mean Wexner incontinence score and low anterior resection syndrome score recorded 18 months following diverting ileostomy closure were 6.3 ± 3.8 and 27.3 ± 3.6, respectively. "
4.	Colostomy 01/01/2022 - "This study aims to evaluate functional and quality-of-life outcomes in patients with low anterior resection syndrome after transanal irrigation using a colostomy irrigation system. " 10/01/2023 - "However, patients with major low anterior resection syndrome scored similarly to those with colostomy. " 10/01/2023 - "Bowel dysfunction was measured using the low anterior resection syndrome score, and patients were then grouped according to (1) colostomy, (2) no/minor, or (3) major low anterior resection syndrome. " 01/01/2022 - "Feasibility Study of Transanal Irrigation Using a Colostomy Irrigation System in Patients With Low Anterior Resection Syndrome." 01/01/2022 - "Colostomy reversal has been performed on 8 (53.3%) patients at an average postoperative duration of 299.5 ± 92.68 days, among whom only 2 patients suffered from major Low Anterior Resection Syndrome (LARS) until now. "
5.	Aftercare (After-Treatment) 04/01/2023 - "Patients are unsure what to expect after treatment and healthcare professionals often underestimate the impact of low anterior resection syndrome on patients' lives. " 01/01/2023 - "On average, low anterior resection syndrome category did not change after treatment (P = .618) and pretreatment low anterior resection syndrome category was a significant independent predictor of post-treatment category (P = .037). " 01/01/2023 - "Bowel-dysfunction was measured using the low anterior resection syndrome score questionnaire (categorized as no, minor, or major low anterior resection syndrome) which was provided to patients at their primary visit, and after treatment. " 12/01/2022 - "Having major low anterior resection syndrome at baseline was the biggest predictor of having major low anterior resection syndrome after treatment. " 01/01/2022 - "Questionnaires assessing patients' bowel function (low anterior resection syndrome and Wexner score) and quality of life (Short Form-36 questionnaire) were applied before and after treatment. "