Quinolizidine Alkaloids

Alkaloids containing QUINOLIZIDINE ring structure. They are found in the genistoid legumes of FABACEAE (formerly Leguminosae) including genera LUPINUS and SOPHORA.

Also Known As:

Alkaloid, Lupin Quinolizidine; Alkaloid, Lupine Quinolizidine; Alkaloid, Quinolizidine; Quinolizidine Alkaloid, Lupin; Quinolizidine Alkaloid, Lupine; Lupin Quinolizidine Alkaloid; Lupin Quinolizidine Alkaloids; Lupine Quinolizidine Alkaloid; Lupine Quinolizidine Alkaloids; Quinolizidine Alkaloid

Networked: 54 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Lin: 10 articles (01/2022 - 01/2011)
2.	Zhang, Guang-Xian: 6 articles (10/2017 - 01/2011)
3.	Chu, Yaojuan: 3 articles (01/2022 - 10/2016)
4.	Zhao, Xiaoyu: 3 articles (01/2022 - 01/2011)
5.	Zhang, Ming-Liang: 3 articles (01/2020 - 07/2017)
6.	Dou, Mengmeng: 2 articles (01/2022 - 01/2021)
7.	Jing, Yilei: 2 articles (01/2022 - 01/2021)
8.	Ma, Rui: 2 articles (01/2022 - 01/2021)
9.	Zhang, Yuan: 2 articles (01/2022 - 01/2018)
10.	Kang, Jian: 2 articles (01/2021 - 10/2017)

Related Diseases

1.	Multiple Sclerosis 07/01/2017 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, has been recently found to be beneficial in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mainly through its anti-inflammatory effect. " 01/01/2011 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been suggested to possess immunomodulatory characteristics; however, whether it is effective in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is not known. " 01/01/2021 - "Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. " 01/01/2020 - "Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), by inducing the production of immunomodulatory molecules, e.g., IL-10. " 10/01/2017 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flavescent, has been recently reported to effectively ameliorate clinical signs in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by secreting antiinflammatory cytokines. "
2.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2021 - "This study aimed to investigate the pathogenesis and potential therapeutic targets of MS and to define target genes of matrine, a quinolizidine alkaloid component derived from the root of Sophorae flavescens that effectively suppressed experimental autoimmune encephalomyelitis (EAE), an animal model of MS. To this end, the GSE108000 gene data set in the Gene Expression Omnibus Database, which included 7 chronic active MS lesions and 10 control samples of white matter, was analyzed for differentially expressed genes (DEGs). " 07/01/2017 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, has been recently found to be beneficial in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis, mainly through its anti-inflammatory effect. " 01/01/2021 - "Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. " 01/01/2020 - "Matrine (MAT), a quinolizidine alkaloid component derived from the root of Sophora flavescens, suppresses experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), by inducing the production of immunomodulatory molecules, e.g., IL-10. " 10/01/2017 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flavescent, has been recently reported to effectively ameliorate clinical signs in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), by secreting antiinflammatory cytokines. "
3.	Autoimmune Diseases (Autoimmune Disease) 01/01/2011 - "Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been suggested to possess immunomodulatory characteristics; however, whether it is effective in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is not known. "
4.	Ischemia 01/01/2011 - "Oxymatrine is the major quinolizidine alkaloid extracted from the root of Sophora flavescens AIT, and has been proved to be protective after ischemia in recent studies. " 01/01/2018 - "Autophagy has been better studied in ischemia/reperfusion (I/R) injuries, and previous work showed that Oxymatrine (OMT), a quinolizidine alkaloid, protects cells against myocardial I/R injury by inhibiting autophagy. "
5.	Neoplasm Metastasis (Metastasis) 08/01/2019 - "The present study was to find out whether punarnavine, the quinolizidine alkaloid, with already proven antimetastatic effect on spontaneous B16F10 pulmonary metastasis has got any effect on a drastic organ-specific breast cancer spread. "

Related Drugs and Biologics

1.	Matrines
2.	oxymatrine
3.	aloperine
4.	Antiviral Agents (Antivirals)
5.	Fluorouracil (Carac)
6.	punarnavine
7.	lupanine
8.	cytisine
9.	sophocarpine
10.	piperidine

Related Therapies and Procedures

1.	Immunomodulation
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Therapeutics