Uterine Didelphys

An abnormality in which the MULLARIAN DUCTS do not properly join to form a single uterus during embryological development instead resulting in complete duplication of uterine horns and duplication of the cervix. Double uterus is associated with double cervix and vagina and sometimes renal agenesis.

Also Known As:

Networked: 32 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Bicornuate Uterus
2.	Menorrhagia
3.	Septate Uterus
4.	Uterine Didelphys
5.	Hereditary renal agenesis

Experts

1.	Chen, Zi-Jiang: 2 articles (03/2015 - 11/2014)
2.	Qin, Yingying: 2 articles (03/2015 - 11/2014)
3.	Jain, S: 2 articles (08/2001 - 02/2001)
4.	Lee, C L: 2 articles (08/2001 - 02/2001)
5.	Soong, Y K: 2 articles (08/2001 - 02/2001)
6.	Wang, C J: 2 articles (08/2001 - 02/2001)
7.	Yen, C F: 2 articles (08/2001 - 02/2001)
8.	Chen, Jin-Long: 1 article (05/2022)
9.	Chen, Liang: 1 article (05/2022)
10.	Ma, Yue-Bing: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Didelphys:

1.	3' Untranslated Regions (3' UTR)IBA 11/01/2014 - "One rare single nucleotide polymorphism rs189587233 in 3' UTR of HOXA9 gene was detected in one patient with didelphic uterus and absent in the 192 controls. "
2.	Nonsense Codon (Nonsense Mutation)IBA 03/01/2015 - "A novel nonsense mutation p.E142X was detected in one woman with a didelphic uterus (1 of 517, 0.19%). "
3.	Levonorgestrel (Plan B)FDA LinkGeneric 01/01/2021 - "Levonorgestrel intrauterine system (IUS) in a patient with uterine didelphys: A case report." 01/01/2021 - "This case demonstrates the use of a single levonorgestrel 13.5 mg intrauterine system (IUS) for contraception in a patient with uterine didelphys. "
4.	Tranexamic Acid (AMCA)FDA Link 01/01/2012 - "This case report represents the role of laparoscopic subtotal hysterectomy in a woman with uterine didelphys, who presented with a long-standing history of menorrhagia, which had not responded to medical treatment with tranexamic acid and mefenamic acid, or cyclical norethisterone. "
5.	TamoxifenFDA LinkGeneric 05/01/2010 - "We present a case of uterine carcinosarcoma occurring in uterine didelphys of a 72-year-old breast cancer patient, who had been treated with tamoxifen for 5 years. " 05/01/2010 - "Carcinosarcoma arising in uterine didelphys after tamoxifen therapy for breast cancer: a case report."
6.	Norethindrone (Norethisterone)FDA LinkGeneric 01/01/2012 - "This case report represents the role of laparoscopic subtotal hysterectomy in a woman with uterine didelphys, who presented with a long-standing history of menorrhagia, which had not responded to medical treatment with tranexamic acid and mefenamic acid, or cyclical norethisterone. "
7.	Mefenamic Acid (Pontal)FDA Link 01/01/2012 - "This case report represents the role of laparoscopic subtotal hysterectomy in a woman with uterine didelphys, who presented with a long-standing history of menorrhagia, which had not responded to medical treatment with tranexamic acid and mefenamic acid, or cyclical norethisterone. "
8.	Diethylstilbestrol (Stilbestrol)FDA Link 05/01/2010 - "Using 3D ultrasound we diagnosed: one case with uterine agenesis; 10 with unicornuate uterus, four of which also underwent MRI; six with didelphic uterus, one of which had MRI; 45 with bicornuate uterus, 12 of which had MRI; 125 with septate uterus (18 with two cervices), 42 of which had MRI (six with two cervices); 96 with arcuate uterus, three of which had MRI; and three with diethylstilbestrol (DES) iatrogenic uterine malformations, all of which had MRI. "
9.	17 alpha-Hydroxyprogesterone Caproate (Delalutin)FDA Link 09/01/2016 - "Use of hydroxyprogesterone caproate to prevent preterm labour in uterine didelphys: a case report." 09/01/2016 - "Here, we report a case: 36 years old, G3P2, known case of uterine didelphys, with history of preterm birth, who successfully carried her pregnancy till term with weekly intramuscular injection of 250 mg hydroxyprogesterone caproate (®Proluton Depot, Zuellig Pharma). "
10.	N 30IBA 03/01/2016 - "The prevalence of anatomical anomalies was 41.5% (n = 78); the type of anatomical anomaly was: cervical weakness 15.9% (n = 30), septate uterus 11.7% (n = 22), and uterine synechiae 9.6% (n = 18), endometrial polyps 1.6% (n = 3), bicornuate uterus 1.1% (n = 2), arcuate uterus 0.5% (n = 1), didelphic uterus 0.5% (n=1), and submucosal myoma 0.5% (n=1). "

Therapies and Procedures

1.	Hysterectomy 01/01/2023 - "She had a didelphic uterus with a duplex cervix, and had undergone subtotal hysterectomy 16 years ago. " 02/01/2018 - "Isolated uterine didelphys requires no treatment in contrast to cervical agenesis, which requires a hysterectomy. " 11/01/2015 - "Total Laparoscopic Hysterectomy: Didelphic Uterus." 01/01/2012 - "Laparoscopic subtotal hysterectomy in a case of uterine didelphys." 11/01/2008 - "Laparoscopic hemi-hysterectomy in treatment of a didelphic uterus with a hypoplastic cervix and obstructed hemi-vagina."
2.	Adjuvant Chemotherapy 04/01/2018 - "A hemi-hysterectomy should be considered for fertility preservation when GTN develops on either side of a didelphic uterus and adjuvant chemotherapy does not result in remission."
3.	Endometrial Ablation Techniques 05/01/2011 - "One patient, two uteri, two endometrial ablations: case report of thermal balloon ablation in uterine didelphys." 08/01/2001 - "Women with identical didelphic uteri and hypoplastic cervix (type 3) underwent uterovaginal canalization with or without endometrial ablation or hemihysterectomy. " 02/01/2001 - "Uterovaginal canalization and endometrial ablation of the obstructed uterine horn with hypoplastic cervix in the didelphic uterus." 02/01/2001 - "Our experience suggests that uterovaginal canalization with prophylactic endometrial ablation may be an efficacious alternative to hysterectomy for management of didelphic uterus with a hypoplastic cervix. " 05/01/2011 - "To describe the clinical application and outcomes after endometrial ablation with ThermachoiceIII (Ethicon, Somerville, NJ) in a patient with uterine didelphys with heavy menstrual bleeding. "
4.	Vaginal Birth after Cesarean 01/01/2019 - "A Case of Vaginal Birth after Cesarean Delivery in a Patient with Uterine Didelphys." 01/01/2015 - "Uterine didelphys and vaginal birth after cesarean delivery."
5.	Therapeutics 11/01/2002 - "Without any further fertility therapy she subsequently conceived twins, with one implantation in each horn of a didelphic uterus. " 05/01/2010 - "Carcinosarcoma arising in uterine didelphys after tamoxifen therapy for breast cancer: a case report."