Developmental Dysplasia of the Hip

Dislocation of the HIP JOINT from an abnormal FEMORAL HEAD to the ACETABULUM relationship. It is most often due to ligamentous laxity, abnormal positioning of the joint and various other developmental, congenital factors, and method of delivery (e.g., OLIGOHYDRAMNIOS). When dislocation is diagnosed in neonates it is referred to as CONGENITAL HIP DYSPLASIA.

Also Known As:

Networked: 950 relevant articles (33 outcomes, 148 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoarthritis
2.	Necrosis
3.	Hip Osteoarthritis (Coxarthrosis)
4.	Pain (Aches)
5.	Femoracetabular Impingement

Experts

1.	Trousdale, Robert T: 12 articles (05/2021 - 09/2002)
2.	Kuo, Ken N: 9 articles (07/2022 - 09/2010)
3.	Wang, Ting-Ming: 8 articles (07/2022 - 09/2010)
4.	Kim, Young-Jo: 8 articles (01/2018 - 09/2009)
5.	Yang, Jing: 7 articles (12/2021 - 12/2009)
6.	Sun, Jing-Yang: 7 articles (08/2021 - 02/2018)
7.	Hu, Yihe: 7 articles (02/2021 - 11/2009)
8.	Sugano, Nobuhiko: 7 articles (01/2021 - 03/2011)
9.	Takao, Masaki: 7 articles (01/2021 - 03/2011)
10.	Wu, Kuan-Wen: 6 articles (07/2022 - 09/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Developmental Dysplasia of the Hip:

1.	N- (2,6- dimethylphenyl)- 4- (((diethylamino)acetyl)amino)benzamideIBA 05/01/2023 - "The epidemiological significance of developmental hip dysplasia focused Wiktor Dega's attention in the 1920s. " 12/31/2020 - "Dega's interest in developmental dysplasia of the hip (DDH) had begun as early as 1929, when he presented in Vilnius a paper about the aetiology and pathogenesis of the disease. " 11/01/2023 - "Although Dega acetabuloplasty is widely used for the treatment of developmental dysplasia of the hip, there is a paucity of data on long-term outcomes. " 07/01/2014 - "Dega acetabuloplasty at the time of open reduction is effective in improving the acetabular coverage of the femoral head, hence improving the stability of reduction and preventing possible surgery in the future for residual acetabular dysplasia in older children with Tönnis grade 3 and 4 developmental dysplasia of the hip (DDH). " 05/01/2023 - "A systematic review of studies reporting outcomes after Dega transiliac pelvic osteotomy (DO) in developmental dysplasia of the hip (DDH) was carried out with a meta-analysis of the pre- and postoperative acetabular index (AI) values. "
2.	MetalsIBA 08/01/2008 - "Improved survivorship of hybrid metal-on-metal hip resurfacing with second-generation techniques for Crowe-I and II developmental dysplasia of the hip." 01/01/2015 - "Favorable results were described using metal rings and conical femoral stems for the treatment of the developmental dysplasia of the hip. " 12/01/2008 - "The short-term results of the metal-on-metal hip resurfacing have been encouraging in the treatment of developmental dysplasia of the hip, with better ROM recovery than conventional THA." 02/01/2007 - "The mid-term results of metal-on-metal resurfacing in patients with Crowe type-I or II developmental dysplasia of the hip were disappointing with respect to the durability of the femoral component. " 08/01/2008 - "The purpose of this study was to determine the influence of improved femoral fixation techniques on the survivorship of metal-on-metal total hip resurfacing prostheses in patients with developmental dysplasia of the hip and to report the long-term results of our patients managed earlier with first-generation fixation techniques. "
3.	Capsules (Microcapsules)IBA 03/13/2023 - "However, few studies had focused on postoperative capsule changes in patients with borderline developmental dysplasia of the hip (BDDH). " 01/01/2021 - "The aim of this study was to immunohistochemically identify and characterize the presence of sensory nerve endings (SNEs) in pulvinar, ligamentum teres (LT), and hip joint capsule (HJC) of children with developmental dysplasia of the hip (DDH). " 01/01/2021 - "Investigation of sensory nerve endings in pulvinar, ligamentum teres, and hip joint capsule: A prospective immunohistochemical study of 36 cases with developmental hip dysplasia." 09/01/2004 - "Mechanoreceptor evaluation of hip joint capsule and ligamentum capitis femoris in developmental hip dysplasia: a preliminary study." 09/01/2021 - "Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip."
4.	Interleukin-6 (Interleukin 6)IBA 01/01/2021 - "Genetic Study of IL6, GDF5 and PAPPA2 in Association with Developmental Dysplasia of the Hip." 01/01/2017 - "Genetic association study of common variants in TGFB1 and IL-6 with developmental dysplasia of the hip in Han Chinese population." 05/01/2011 - "Association of interleukin-6 and transforming growth factor-β1 gene polymorphisms with developmental hip dysplasia and severe adult hip osteoarthritis: a preliminary study." 04/01/2015 - "Association of TGFB1 29C/T and IL6 -572G/C polymorphisms with developmental hip dysplasia: a case-control study in adults with severe osteoarthritis." 01/01/2021 - "Key words: developmental dysplasia of the hip, interleukin-6, transforming growth factor beta 1, case control study."
5.	ElementsIBA 01/01/2020 - "The purpose of this study was to establish the finite element analysis (FEA) model of acetabular bone defect in Crowe type II or III developmental dysplasia of the hip (DDH), which could evaluate the stability of the acetabular cup with different types of bone defects, different diameters of femoral ceramic heads, and the use of screws and analyze the stress distribution of screws. " 05/14/2022 - "Based on the Digital Imaging and Communications in Medicine (DICOM) data of three-dimensional magnetic resonance imaging (3D-MRI), finite element models of the hip joints of children with developmental dysplasia of the hip were established. " 05/14/2022 - "Evaluation of the short-term curative effect of closed reduction in the treatment of developmental dysplasia of the hip based on three-dimensional magnetic resonance imaging finite element analysis." 09/08/2020 - "Contact pressure distribution of the hip joint during closed reduction of developmental dysplasia of the hip: a patient-specific finite element analysis." 01/01/2020 - "Acetabular Bone Defect in Total Hip Arthroplasty for Crowe II or III Developmental Dysplasia of the Hip: A Finite Element Study."
6.	3,5-tetrahydroaldosterone sulfate (THAS)IBA 07/18/2021 - "A registry study was performed to query survival rates, hazard ratios, and reasons for revision of different stem designs in THAs after developmental dysplasia of the hip. " 09/01/2009 - "A retrospective analysis was conducted of a single surgeon's series of 31 THAs performed in 25 patients with developmental hip dysplasia. " 04/28/2021 - "We previously reported the 9-year follow-up results of 121 cementless total hip arthroplasties (THAs) from 1990 to 1994 in 93 patients with developmental dysplasia of the hip (DDH). " 02/01/2015 - "When compared with a matched cohort of patients who underwent THAs for developmental dysplasia of the hip (DDH) without previous periacetabular osteotomy, we asked whether a THA after a periacetabular osteotomy has (1) a higher complication rate, (2) a higher likelihood of resulting in revision THA, (3) comparable improvements in Harris hip score, and (4) comparable radiographic results. " 01/01/2011 - "We performed 103 primary THAs in 87 patients with osteoarthritis secondary to developmental dysplasia of the hip with a minimum 3-year followup. "
7.	GadoliniumIBA 01/01/2021 - "Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) is a validated technique for evaluating cartilage health in developmental dysplasia of the hip (DDH), which can be a helpful prognosticator for the response to surgical treatments. " 09/01/2019 - "Spica MRI with intravenous gadolinium contrast after closed reduction for developmental dysplasia of the hip (DDH) helps to determine successful reduction and attempts to identify patients at risk for epiphyseal osteonecrosis. " 05/01/2016 - "Gadolinium-enhanced perfusion MRI (pMRI) after closed reduction/spica casting for developmental dysplasia of the hip (DDH) has been suggested as a potential means to identify and avoid avascular necrosis (AVN). " 11/01/2010 - "To assess the pattern of cartilage damage in symptomatic cases of developmental dysplasia of the hip (DDH) and of femoroacetabular impingement (FAI) with a novel three-dimensional (3D) delayed Gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) technique. " 07/01/2012 - "The aim of this study was to evaluate differences in damage patterns assessed using magnetic resonance imaging (MRI) between hips with femoroacetabular impingement (FAI) and developmental dysplasia of the hip (DDH) as well as to correlate MRI findings with delayed Gadolinium enhanced MRI of cartilage (dGEMRIC) and with patient pain. "
8.	SolutionsIBA 01/01/2023 - "Closed reduction and plaster immobilization: an alternative solution for patients with developmental dysplasia of the hip who failed Pavlik harness treatment." 01/01/2019 - "Similar with STO, the clinical results of PFR technique are a reliable solution for femoral procedure during THA in patients with Hartofilakidis type C developmental dysplasia of the hip." 11/01/2016 - "Developmental dysplasia of the hip (DDH) is a common cause of secondary osteoarthritis (OA) in younger patients, and when end-stage OA develops, a THA can provide a solution. " 08/22/2023 - "In this study, we aimed to investigate whether the use of epinephrine solution-impregnated gauzes and irrigation fluid with epinephrine could reduce perioperative blood loss during the combined surgical treatment of developmental dysplasia of the hip (DDH) patients. "
9.	Therapeutic UsesIBA 01/01/2019 - "The contact pressure we simulated can plausibly account for both the therapeutic effects and main adverse effect of abduction harness treatment for developmental dysplasia of the hip. " 03/01/2011 - "We believe that preoperation overall evaluation and personalized operation plans, experience with the surgical procedure, and commencement of functional exercise soon after the operation are the main reasons for the satisfactory therapeutic effects achieved in this study after surgery for developmental dysplasia of the hip presenting in children older than 10 years." 04/01/2012 - "To retrospectively compare the therapeutic effects of simple Pemberton's ilium osteotomy and combined unter-trochanter derotation-varisation osteotomy for developmental dysplasia of the hip (DDH). "
10.	Calcitriol Receptors (Calcitriol Receptor)IBA 06/28/2007 - "We investigated the association of developmental dysplasia of the hip (DDH) and primary protrusion acetabuli (PPA) with Vitamin D receptor polymorphisms Taq I and Fok I and oestrogen receptor polymorphisms Pvu II and Xba I. 45 patients with DDH and 20 patients with PPA were included in the study. " 09/01/2018 - "Association analysis between four vitamin D receptor gene polymorphisms and developmental dysplasia of the hip." 01/07/2021 - "Are vitamin D and vitamin D receptor levels different in children with developmental dysplasia of the hip?"

Therapies and Procedures

1.	Osteotomy 05/01/2021 - "The study was carried out based on the background that though proximal femoral varus osteotomy is one of the most effective methods in treating developmental dysplasia of the hip (DDH), its surgical efficiency and effect need to be improved. " 01/01/2023 - "Although eccentric acetabular rotation osteotomy (ERAO) is an effective treatment for developmental dysplasia of the hip (DDH), there is little information about return to sports after ERAO. " 01/01/2022 - "Classic and reverse Bernese periacetabular osteotomy (PAO) have been shown to be effective for the treatment of developmental dysplasia of the hip (by classic PAO), severe acetabular retroversion (by reverse PAO), and some protrusio acetabuli (by reverse PAO). " 12/19/2021 - "Bernese periacetabular osteotomy (PAO) is an effective treatment for patients with developmental dysplasia of the hip (DDH). " 12/01/2020 - "Bernese periacetabular osteotomy (PAO), an effective treatment for patients with developmental dysplasia of the hip (DDH), is characterized by wide exposure, cancellous bone surgery, and difficult techniques. "
2.	Hip Replacement Arthroplasty (Total Hip Replacement) 02/01/2021 - "Patient-specific total hip arthroplasty is superior to conventional methods for Crowe III and IV adult developmental hip dysplasia: a randomized controlled trial." 12/01/2008 - "Total hip arthroplasty (THA) with ceramic-on-ceramic bearings and an uncemented design is considered an effective treatment of developmental dysplasia of the hip, especially for young, active patients. " 09/01/2017 - "Efficacy of a computed tomography-based navigation system for placement of the acetabular component in total hip arthroplasty for developmental dysplasia of the hip." 03/01/2010 - "To evaluate the efficacy of total hip arthroplasty (THA) combined with femoral head autograft for Crowe type II and type III developmental dysplasia of the hip (DDH). " 01/01/2024 - "This study aimed to determine (1) whether acetabular reconstruction techniques influenced the position of the acetabular cup and (2) whether clinical outcomes based on the acetabular reconstruction techniques differ in patients undergoing total hip arthroplasty (THA) with Crowe II to III developmental dysplasia of the hip. "
3.	Acetabuloplasty 01/01/2022 - "This study aimed to present the clinical and radiological results of a large patient group operated by Tönnis lateral acetabuloplasty (TLA) for developmental dysplasia of the hip (DDH). " 11/01/2016 - "In this study, we aimed to evaluate the long-term clinical and radiological results of single-stage open reduction through a medial approach and Pemberton acetabuloplasty in developmental dysplasia of the hip. " 10/01/2010 - "This study describes the radiologic results of 147 hips treated for developmental hip dislocation by means of a standard protocol of open hip reduction and pericapsular acetabuloplasty with a contoured iliac crest allograft as the interposition material. " 10/08/2023 - "Shelf acetabuloplasty has been performed in patients with developmental dysplasia of the hip (DDH); however, the appropriate position of the shelf has not been determined, particularly with respect to avoiding range of motion (ROM) loss. " 07/01/2023 - "Arthroscopic labral repair combined with less invasive open-shelf acetabuloplasty for patients with developmental dysplasia of the hip."
4.	Arthroplasty 07/01/2015 - "Our study suggests that cementless arthroplasty with a distal femoral shortening is a safe and effective procedure for severe developmental dysplasia of the hip." 08/01/2016 - "Experimental study of the installation acetabular component with uncoverage in arthroplasty patients with severe developmental hip dysplasia." 08/01/2023 - "Femoral head and neck autograft in arthroplasty for developmental dysplasia of the hip: a systematic review of long-term outcomes." 06/01/2023 - "Telescoping Allograft Prosthetic Composite (APC) Reconstruction of the Femur Following Revision Arthroplasty for Neglected Developmental Dysplasia of the Hip (DDH)." 01/01/2019 - "Developmental Dysplasia of the Hip From Birth to Arthroplasty: Clear Indications and New Controversies."
5.	Prostheses and Implants (Prosthesis) 01/01/2023 - "Objective: This study aimed to evaluate the biomechanical effectiveness of 3D-printed integrated acetabular prosthesis (IAP) and modular acetabular prosthesis (MAP) in reconstructing the acetabulum for patients with Crowe III developmental dysplasia of the hip (DDH). " 05/14/2021 - "Modular prosthesis fracture in a patient with developmental dysplasia of the hip: a case report and literature review." 08/01/2015 - "To investigate the anatomical morphology of the proximal femur in adult patients with Crowe type IV developmental dysplasia of the hip (DDH) so as to provided a reference for the selection of femoral components or personalized artificial prosthesis for DDH. " 03/16/2011 - "Twenty-five consecutive patients (thirty-three hips) who had previously had Crowe Group-IV developmental dysplasia of the hip were treated with a modular cementless prosthesis at a mean age of sixty years. " 01/01/2011 - "The results of this series support the use of modular neck prostheses as an effective alternative in the treatment of developmental dysplasia of the hip. "