Specific Language Disorder

Language disorder that delays the mastery of oral language skills or in children who have no hearing loss or other developmental delays.

Also Known As:

Disorder, Specific Language; Disorders, Specific Language; Impairment, Specific Language; Impairments, Specific Language; Language Disorder, Specific; Language Disorders, Specific; Language Impairment, Specific; Language Impairments, Specific; Specific Language Disorders; Specific Language Impairments; Specific Language Impairment

Networked: 115 relevant articles (2 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
2.	Autism Spectrum Disorder
3.	Dyslexia (Alexia)
4.	Speech Sound Disorder
5.	Neurodevelopmental Disorders

Experts

1.	Leonard, Laurence B: 6 articles (09/2013 - 04/2002)
2.	Verhoeven, Ludo: 5 articles (01/2019 - 05/2011)
3.	Chiat, Shula: 4 articles (10/2018 - 09/2009)
4.	Langereis, Margreet C: 3 articles (01/2019 - 02/2015)
5.	de Hoog, Brigitte E: 3 articles (01/2019 - 02/2015)
6.	van Weerdenburg, Marjolijn: 3 articles (01/2019 - 02/2015)
7.	Rice, Mabel L: 3 articles (01/2018 - 12/2009)
8.	Morgan, Gary: 3 articles (05/2014 - 01/2007)
9.	Deevy, Patricia: 3 articles (09/2013 - 04/2002)
10.	Alloway, Tracy Packiam: 3 articles (07/2009 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Specific Language Disorder:

1.	cerebrolysinIBA 01/01/2015 - "To study different forms of specific language impairment in children and to evaluate the efficacy of cerebrolysin in clinical and electroencephalographic aspects. " 01/01/2015 - "[Clinical and electroencephalographic characteristics of specific language impairment in children and an evaluation of the efficacy of cerebrolysin]."
2.	Biomarkers (Surrogate Marker)IBA 09/01/2013 - "Clinical markers in Italian-speaking children with and without specific language impairment: a study of non-word and real word repetition as predictors of grammatical ability." 10/01/2011 - "The purpose of this study was to test Bedore and Leonard's (1998) proposal that a verb morpheme composite may hold promise as a clinical marker for specific language impairment (SLI) in English speakers and serve as an accurate basis for the classification of children with and without SLI beyond the preschool level. " 12/01/2009 - "Judgments of omitted BE and DO in questions as extended finiteness clinical markers of specific language impairment (SLI) to 15 years: a study of growth and asymptote." 11/01/2006 - "The discovery of clinical markers for specific language impairment (SLI) in children can assist in the accurate identification of children with this disorder, and in a description of the disorder's phenotype for genetic study. " 12/01/2018 - "The finding of biological markers of specific language impairment would facilitate their detection and early intervention. "
3.	Silver Sulfadiazine (SSD)FDA LinkGeneric 02/01/2008 - "This study employed more precise speech-language diagnostic criteria and examined ADHD symptomatology in 108 SSD children between the ages of 4 and 7 years old with specific language impairment (SLI) (n = 23, 14 males, 9 females) and without SLI (n = 85, 49 males, 36 females). " 11/09/2023 - "Children with specific language impairment (SLI) might present with speech sound disorder (SSD) and phonological awareness (PA) deficits which put them at risk of potential reading problems. " 01/01/2014 - "Although research has demonstrated that children with specific language impairment (SLI) and reading disorder (RD) exhibit sustained attention deficits, no study has investigated sustained attention in children with speech sound disorder (SSD). " 10/21/2010 - "In this review, we summarize advances in the genetic investigation of stuttering, speech-sound disorder (SSD), specific language impairment (SLI), and developmental verbal dyspraxia (DVD). " 10/05/2007 - "These problems especially comprise of a variety of disorders which may be subclassified to attention-deficit hyperactivity disorder (ADHD), reading disability (RD), specific language impairment (SLI), speech-sound disorder (SSD), and dyspraxia. "
4.	Complement System Proteins (Complement)IBA 10/01/2011 - "This study investigated the use of cognitive state verbs (CSVs) and complement clauses in children with specific language impairment (SLI) and their typically developing (TD) peers. " 06/01/2006 - "The purpose of this study was to explore whether 13 children with specific language impairment (SLI; ages 5;1-8;0 [years;months]) were as proficient as typically developing age- and vocabulary-matched children in the production of finite and nonfinite complement clauses. " 06/01/2006 - "The production of finite and nonfinite complement clauses by children with specific language impairment and their typically developing peers." 04/01/2004 - "False belief and sentence complement performance in children with specific language impairment."
5.	Proteins (Proteins, Gene)FDA Link 12/01/2021 - "We selected four candidate genes (TM4SF20, NFXL1, CNTNAP2 and ATP2C2) strongly suggested for specific language impairment (SLI), a subtype of LI, and investigated rare protein coding variants through Sanger sequencing of probands with LI ascertained from Pakistan. " 04/15/2016 - "One of these genes - contactin-associated-like-protein 2 (CNTNAP2) - was first associated with Specific Language Impairment, and more recently has been linked to ASD. " 05/01/2011 - "We examined association of a susceptibility gene, contactin-associated protein-like 2 (CNTNAP2), for ASDs and specific language impairment with SM and social anxiety-related traits. " 04/01/2013 - "Recently, several studies have pinpointed the involvement of common variants of the Contactin-Associated Protein-Like 2 (CNTNAP2) gene, whose transcription is regulated by the product of FOXP2, in several disorders characterized by language impairments such as autism, specific language impairment (SLI), and selective mutism (SM). " 01/01/2014 - "Variants of the contactin associated protein-like 2 (Cntnap2) gene are risk factors for language-related disorders including autism spectrum disorder, specific language impairment, and stuttering. "
6.	SolutionsIBA 06/01/1995 - "This study explored the conflict resolution ability of 30 children with specific language impairment (SLI) and 30 children with normal language (NL) in grades 3 through 7. The children participated in a hypothetical problem-solving activity in which an imaginary conflict was presented and a hypothetical solution was required. " 07/01/2014 - "One solution is to retain specific language impairment, with the understanding that 'specific' means idiopathic (i.e., of unknown origin) rather than implying there are no other problems beyond language. "
7.	Temazepam (Nocturne)FDA LinkGeneric 12/01/1997 - "In this study, magnetic resonance imaging (MRI) was used for quantitative comparisons of the planum temporale (Wernicke's area) and pars triangularis (Broca's area) in children with specific language impairment (SLI) and children with normal language skills. "
8.	NeuroliginsIBA 02/01/2011 - "After a brief overview of this field of research and the neural basis of primate vocalizations, we review studies that have addressed the genetic basis of usage and structure of ultrasonic communication in mice, with a focus on the gene FOXP2 involved in specific language impairments and neuroligin genes (NL-3 and NL-4) involved in autism spectrum disorders. "
9.	N-methyl-4-methoxynaphthalimideIBA 02/01/2014 - "The study aimed to assess the use of Integrated Mismatch Negativity (MMNi) in differentiating children with specific language impairment (SLI) from a control group. "
10.	A-factor (Streptomyces)IBA 04/01/2002 - "The purpose of this preliminary study was to determine if emotion regulation warrants investigation as a factor influencing social outcomes in children with specific language impairment (SLI). "

Therapies and Procedures

1.	Speech Therapy (Therapy, Speech) 04/25/2002 - "Efficacy of speech therapy in children with language disorders: specific language impairment compared with language impairment in comorbidity with cognitive delay." 12/01/2021 - "[Long-term course after inpatient speech therapy: educational and language development of children with severe specific language impairment (SLI)]."
2.	Sign Language 01/01/2014 - "The studies discussed in this review come principally from children with specific language impairment, and from children who are English-speakers or deaf users of British sign language. " 03/01/2010 - "This paper presents the first ever group study of specific language impairment (SLI) in users of sign language. " 04/01/2017 - "This article describes the case of a deaf native signer of American Sign Language (ASL) with a specific language impairment (SLI). " 04/01/2017 - "A Case of Specific Language Impairment in a Deaf Signer of American Sign Language." 05/01/2014 - "Deficits in narrative abilities in child British Sign Language users with specific language impairment."
3.	Cochlear Implants (Cochlear Implant) 01/01/2021 - "The present study analyzed the morpho-syntactic discrepancies among three children with cochlear implant (CI), with the aim of understanding if morpho-syntactic deficits may be characterized as a domain-specific language disorder. " 02/01/2015 - "In this study we compared lexical access to spoken words in 25 deaf children with cochlear implants (CIs), 13 hard-of-hearing (HoH) children and 20 children with specific language impairment (SLI). " 01/01/2019 - "Spoken language development in school-aged children with cochlear implants as compared to hard-of-hearing children and children with specific language impairment." 01/01/2019 - "A battery of standardized language tests and control measures was administered to three groups of at-risk language learners - internationally adopted children, deaf children with cochlear implants, and children with specific language impairment - and to groups of second-language learners and typically developing monolingual children. " 01/01/2008 - "A methodological contribution to the assessment of nonword repetition-a comparison between children with specific language impairment and hearing-impaired children with hearing aids or cochlear implants."
4.	Therapeutics 07/01/2013 - "Few studies report on therapy to improve language comprehension in children with specific language impairment (SLI). " 01/01/2023 - "Specific language impairment (SLI) is one of the most common diseases in children, and early diagnosis can help to obtain better timely therapy economically. " 01/01/2017 - "Cross-linguistic transfer effects after phonologically based cognate therapy in a case of multilingual specific language impairment (SLI)." 07/01/2011 - "Parent-Child Interaction Therapy (PCIT) in school-aged children with specific language impairment." 09/01/2009 - "To investigate the effectiveness of different models of therapy provision for children with specific language impairment between the ages of 4;00 and 4;06 years. "
5.	Prenatal Care (Care, Prenatal) 07/01/2006 - "Most studies demonstrated that the following factors affect language development--antenatal care, Apgar scores, birth weight, premature delivery, birth order, parental education, environmental factors, gender of the children, and family history with specific language impairment. "