Type A Trichothecenes

A subclass of Trichothecene derivatives that include the 12,13-epoxytrichothec-9-ene structure of the molecule with the C-8 position containing either no oxygen substitution, a hydroxyl group at C-8, or an ester function at C-8.

Also Known As:

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wu, Wenda: 3 articles (01/2018 - 04/2016)
2.	Zhang, Haibin: 2 articles (01/2018 - 01/2017)
3.	Zhang, Jie: 2 articles (01/2018 - 01/2017)
4.	Dietrich, Richard: 1 article (01/2019)
5.	Elßner, Thomas: 1 article (01/2019)
6.	Märtlbauer, Erwin: 1 article (01/2019)
7.	Pöhlmann, Christopher: 1 article (01/2019)
8.	Schulz, Katharina: 1 article (01/2019)
9.	Liu, Shengli: 1 article (01/2018)
10.	Zhang, Hua: 1 article (01/2018)

Related Diseases

1.	Anorexia 01/01/2018 - "Although anorexia is a common hallmark of type B trichothecenes-induced toxicity, less is known about the anorectic potencies of type A trichothecenes. " 01/01/2017 - "In this study, we hypothesized that anorexia induced by type A trichothecenes, including T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO), in mice corresponds to the changes in the gut satiety hormones peptide YY3-36 (PYY3-36) and glucose-dependent insulinotropic polypeptide (GIP) in plasma. "
2.	Shellfish Poisoning 01/01/2019 - "Phycotoxins and mycotoxins, such as paralytic shellfish poisoning toxins, type A trichothecenes, and aflatoxins are among the most toxic low molecular weight toxins associated with human poisoning incidents through the consumption of naturally contaminated food. "
3.	Vomiting 04/01/2016 - "Here, we characterized the emetic responses in the mink to T-2 toxin (T-2) and HT-2 toxin (HT-2), two highly toxic Type A trichothecenes that contaminate cereals, and further compared these effects to those of emetine, a natural alkaloid that is used medicinally and also well known to block translation and cause vomiting. "
4.	Poisoning 01/01/2019 - "Phycotoxins and mycotoxins, such as paralytic shellfish poisoning toxins, type A trichothecenes, and aflatoxins are among the most toxic low molecular weight toxins associated with human poisoning incidents through the consumption of naturally contaminated food. "
5.	Necrosis 09/01/2006 - "In contrast, type A trichothecenes reduce the mitochondrial activity at approximately 1000-fold lower concentrations than the type B trichothecenes, resulting in necrosis. "

Related Drugs and Biologics

1.	T-2 Toxin (T 2 Toxin)
2.	HT-2 toxin
3.	Peptide Hormones (Polypeptide Hormones)
4.	Peptides (Polypeptides)
5.	Glucose (Dextrose)
6.	amsonic acid (DAS)
7.	neosolaniol
8.	diacetoxyscirpenol
9.	Type B Trichothecenes
10.	Mycotoxins