Intermittent Renal Replacement Therapy

Procedures with non-continuous blood purification (e.g., dialysis, filtration and/or perfusion) via vascular access by increasing blood flow rate compared to CONTINUOUS RRT.

Also Known As:

Accelerated Veno Venous Hemofiltration; Hemodiafiltration, Intermittent Veno-Venous; Hemodiafiltration, Intermittent Venovenous; Hemofiltration, Accelerated Veno-Venous; Hemofiltration, Accelerated Venovenous; IRRT Techniques; Intermittent RRTs; Intermittent Veno Venous Hemodiafiltration; Intermittent Veno-Venous Hemodiafiltrations; Intermittent Venovenous Hemodiafiltrations; RRT, Intermittent; Technique, IRRT; Veno-Venous Hemofiltration, Accelerated; Venovenous Hemodiafiltration, Intermittent; Venovenous Hemofiltration, Accelerated; Accelerated Veno-Venous Hemofiltration; Accelerated Venovenous Hemofiltration; IRRT Technique; Intermittent RRT; Intermittent Veno-Venous Hemodiafiltration; Intermittent Venovenous Hemodiafiltration; PIRRT; Prolonged Intermittent Renal Replacement Therapy

Networked: 83 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Roberts, Jason A: 4 articles (11/2019 - 01/2018)
2.	Mueller, Bruce A: 4 articles (10/2018 - 07/2016)
3.	Kielstein, Jan T: 3 articles (12/2021 - 08/2018)
4.	Schmidt, Julius J: 3 articles (12/2021 - 08/2018)
5.	Bagshaw, Sean M: 3 articles (06/2021 - 12/2006)
6.	Cheng, Vesa: 3 articles (11/2019 - 01/2018)
7.	Dyer, John: 3 articles (11/2019 - 01/2018)
8.	Rawlins, Matthew: 3 articles (11/2019 - 01/2018)
9.	Lewis, Susan J: 3 articles (10/2018 - 10/2016)
10.	Bellomo, Rinaldo: 3 articles (01/2018 - 02/2008)

Related Diseases

1.	Pancreatitis 01/01/2023 - "The aim of this study was to investigate the efficacy of prolonged intermittent renal replacement therapy (PIRRT) plus hemoperfusion (HP) in treating moderately severe acute pancreatitis (MSAP) and severe acute pancreatitis (SAP). " 01/01/2023 - "PIRRT + HP therapy could not only improve the general conditions, as measured by APACHE II score, but also reduce the inflammatory cascade of patients with acute pancreatitis. " 01/01/2023 - "Prolonged Intermittent Renal Replacement Therapy Combined with Hemoperfusion Can Improve Early Recovery of Moderate and Severe Acute Pancreatitis, Especially in Patients with Acute Kidney Injury."
2.	COVID-19 01/01/2021 - "PIRRT may be beneficial for the treatment of COVID-19 patients with invasive mechanical ventilation. " 01/01/2021 - "Deployment of a New CRRT/PIRRT Device during the COVID-19 Pandemic Emergency: Organizational Challenges and Implementation Results." 01/01/2021 - "We aimed to assess the association between prolonged intermittent renal replacement therapy (PIRRT) and mortality in patients with COVID-19 undergoing invasive mechanical ventilation. " 01/01/2021 - "Association between Prolonged Intermittent Renal Replacement Therapy and All-Cause Mortality in COVID-19 Patients Undergoing Invasive Mechanical Ventilation: A Retrospective Cohort Study." 01/01/2021 - "PIRRT may represent an acceptable alternative of renal replacement therapy during the COVID-19 outbreak."
3.	Critical Illness (Critically Ill) 11/01/2023 - "Thirty-nine studies enrolling 452 patients met criteria for inclusion and provided PK and/or PD data for 20 antimicrobials in critically ill adults receiving PIRRT. " 01/01/2021 - "We searched the electronic databases for randomized controlled trials (RCTs) comparing different RRT modalities, including continuous RRT, intermittent RRT, hybrid RRT, and peritoneal dialysis (PD), in critically ill patients with AKI through July 26, 2020. " 05/01/2015 - "This trial aimed to compare the dialysis complications occurring during different durations of PIRRT sessions in critically ill AKI patients. " 11/01/2023 - "A search strategy for multiple databases was designed and executed to identify relevant published evidence describing the PK of antimicrobials used in critically ill adults receiving PIRRT. " 11/01/2023 - "The objectives of this systematic review were to: (1) identify and describe the pharmacokinetics (PK) of relevant antimicrobials used in critically ill adults receiving PIRRT, (2) evaluate the quality of evidence supporting these data, and (3) propose dosing recommendations based on the synthesis of these data. "
4.	Acute Kidney Injury (Acute Renal Failure) 05/01/2021 - "Studies assessing prognosis after prolonged intermittent renal replacement therapy (PIRRT) for acute kidney injury (AKI) are scarce. " 01/01/2023 - "As an effective measurement for severe acute kidney injury (AKI), the prolonged intermittent renal replacement therapy (PIRRT) received attention. " 01/01/2023 - "Short-term prognostic models for severe acute kidney injury patients receiving prolonged intermittent renal replacement therapy based on machine learning." 01/01/2022 - "Though cost-effectiveness analyses (CEAs) have evaluated continuous renal replacement therapy (RRTs) and intermittent RRTs in acute kidney injury (AKI) patients; it is yet to establish which RRT technique is most cost-effective. " 01/01/2022 - "A systematic review of cost-effectiveness analyses of continuous versus intermittent renal replacement therapy in acute kidney injury."
5.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2019 - "Patients who underwent continuous renal replacement therapy in the AKI-D group exhibited comparable mortality and risk of MACEs but reduced progression to ESRD compared to those who received intermittent renal replacement therapy. " 04/01/2015 - "We identified adult patients without end-stage renal disease who had been admitted to ICUs for 3 days or longer and started continuous RRT (CRRT) or intermittent RRT (IRRT). " 12/01/2023 - "Our objectives were to evaluate meropenem clearance in a child with ESRD with and without PIRRT, compare the results to previous continuous renal replacement therapy studies in children, toddlers and neonates, and assess whether the currently used dose of meropenem is sufficient. " 10/01/2002 - "Recent studies showed that r-hirudin anticoagulation is feasible in acute or chronic renal failure treated with continuous or intermittent renal replacement therapy, if appropriate r-hirudin dosing and adequate monitoring are warranted. " 12/01/2023 - "Predicting meropenem clearance in children with ESRD undergoing PIRRT is difficult as clearance will be affected by renal function, PIRRT settings and other factors. "

Related Drugs and Biologics

1.	Meropenem (Merrem)
2.	Vancomycin
3.	Imipenem
4.	Prodrugs
5.	Hirudins
6.	Colistin (Coly-Mycin)
7.	Ertapenem (Invanz)
8.	Doripenem
9.	methanesulfonic acid (methanesulfonate)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Intermittent Renal Replacement Therapy
2.	Hemoperfusion
3.	Artificial Respiration (Mechanical Ventilation)
4.	Continuous Renal Replacement Therapy
5.	Hybrid Renal Replacement Therapy