Protein Kinase C-theta

A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

Also Known As:

Networked: 123 relevant articles (4 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Altman, Amnon: 5 articles (01/2013 - 01/2002)
2.	Chida, Noboru: 3 articles (01/2019 - 07/2015)
3.	Kunikawa, Shigeki: 3 articles (01/2019 - 07/2015)
4.	Tanaka, Akira: 3 articles (01/2019 - 07/2015)
5.	Tasaki, Mamoru: 3 articles (01/2019 - 07/2015)
6.	Zhang, Jian: 2 articles (01/2021 - 04/2008)
7.	Irie, Hanna Y: 2 articles (01/2020 - 01/2016)
8.	Chen, Feilan: 2 articles (01/2019 - 01/2016)
9.	Hou, Shengping: 2 articles (01/2019 - 01/2016)
10.	Takasuna, Yuji: 2 articles (01/2019 - 11/2018)

Related Diseases

1.	Insulin Resistance 03/01/2008 - "This provides a new mechanism linking PKC theta activation to insulin resistance." 09/01/2004 - "To test this hypothesis, we examined whether mice with inactivation of PKC-theta are protected from fat-induced insulin resistance in skeletal muscle. " 09/01/2004 - "PKC-theta knockout mice are protected from fat-induced insulin resistance." 11/01/2000 - "However, only membrane PKC-theta was reduced to the level of chow-fed controls when insulin resistance was reversed in HF-G rats [% PKC-theta at membrane, 23.0 +/- 4.4% (C); 39.7 +/- 3.4% (HF-F, P < 0.01 vs. C); 22.5 +/- 2.7% (HF-G, P < 0.01 vs. HF-F), by ANOVA]. " 11/01/2000 - "Here, we have used this model to determine whether changes in the translocation of PKC-theta and -epsilon are associated with the acute reversal of insulin resistance. "
2.	Obesity 07/01/2003 - "Taken together these data demonstrate that over-expression of dominant negative PKC-theta in skeletal muscle causes obesity associated to insulin resistance, as demonstrated by defective receptor and post-receptorial activation of signaling cascade." 07/01/2003 - "Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity." 09/01/2009 - "Finally, arcuate-specific knockdown of PKC-theta attenuated diet-induced obesity and improved insulin signaling. " 03/01/2008 - "Protein kinase C (PKC) theta activation is associated with insulin resistance and obesity, but the underlying mechanisms have not been fully elucidated. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 11/28/2022 - "Importantly, our results showed that aspalathin treatment was effective in ameliorating the devastating outcomes of insulin resistance and mitochondrial dysfunction that are linked with an undesired pro-inflammatory response, by reducing the levels of well-known pro-inflammatory markers such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and protein kinase C-theta (PKC-theta). "
4.	Listeriosis (Listeria Infection) 04/15/2008 - "In listeriosis, transfer of wild-type T cells into PKC-theta(-/-) mice resulted in a normal control of Listeria, and, additionally, a selective expression of PKC-theta in LM-specific T cells was sufficient to drive a normal proliferation and survival of these T cells in LM-infected PKC-theta(-/-) recipients, illustrating a cell-autonomous function of PKC-theta in LM-specific T cells. " 04/15/2008 - "In primary and secondary listeriosis, the numbers of LM-specific CD8 and CD4 T cells were drastically reduced in PKC-theta(-/-) mice, resulting in increased CFUs in spleen and liver of both PKC-theta(-/-) C57BL/6 and BALB/c mice. " 04/15/2008 - "Protein kinase C-theta critically regulates the proliferation and survival of pathogen-specific T cells in murine listeriosis." 04/15/2008 - "Additionally, in vitro experiments showed that only the addition of IL-2, but not an inhibition of caspase-3, induced proliferation and prevented death of PKC-theta(-/-) T cells stimulated with LM-infected wild-type dendritic cells, further demonstrating that the impaired proliferation and survival of PKC-theta(-/-) T cells in listeriosis is not intrinsically fixed and can be experimentally improved."
5.	Arthritis (Polyarthritis) 08/01/2006 - "Collectively, our results demonstrate that PKC-theta deficiency results in an attenuated response to Ag-induced arthritis, which is likely mediated by the reduced T cell proliferation, Th1/Th2 cell differentiation and T cell activation before and during disease peak." 08/01/2006 - "We examined the effects of PKC-theta deficiency on two Th1-dependent models of Ag-induced arthritis and found that PKC-theta-deficient mice develop disease, but at a significantly diminished severity compared with wild-type mice. " 08/01/2006 - "In the type II collagen-induced arthritis model, we observed a significant reduction in clinical scores (p < 0.01) in three independent experiments and diminished joint pathology (p < 0.005) in PKC-theta-deficient compared with wild-type littermates. " 08/01/2006 - "PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis."

Related Drugs and Biologics

1.	Protein Kinase C-theta
2.	Insulin (Novolin)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Interleukin-6 (Interleukin 6)
5.	Interleukin-2 (IL2)
6.	Caspase 3 (Caspase-3)
7.	Collagen Type II (Type II Collagen)
8.	aspalathin
9.	Isoenzymes
10.	Protein Kinase C

Related Therapies and Procedures

1.	Transplantation
2.	Thymectomy
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Denervation