Cytokine TWEAK

A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

Also Known As:

Networked: 37 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Burkly, Linda C: 6 articles (09/2015 - 12/2006)
2.	Ortiz, Alberto: 4 articles (02/2016 - 04/2008)
3.	Ruiz-Ortega, Marta: 4 articles (02/2016 - 04/2008)
4.	Winkles, Jeffrey A: 4 articles (11/2014 - 02/2005)
5.	Burkly, Linda: 3 articles (11/2021 - 03/2007)
6.	Egido, Jesús: 3 articles (02/2016 - 04/2008)
7.	Michaelson, Jennifer S: 3 articles (05/2015 - 12/2006)
8.	Xia, Yumin: 2 articles (01/2021 - 05/2015)
9.	Altunsoy, Neslihan: 2 articles (11/2017 - 10/2015)
10.	Aydemir, Makbule Çiğdem: 2 articles (11/2017 - 10/2015)

Related Diseases

1.	Bipolar Disorder (Manic Depressive Psychosis) 01/01/2021 - "Serum TNF- Related Weak Inducer of Apoptosis (TWEAK), TNF- Related Apoptosis-Inducing Ligand (TRAIL) Levels in Patients with Bipolar Depression, Major Depression and a Healthy Control Group." 11/01/2017 - "Serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels of patients with bipolar disorder in manic episode, in remission and healthy controls." 01/01/2021 - "The aim of this study was to investigate the serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels in patients with bipolar depression (BD), MDD and a healthy control (HC) group to determine any differences between MDD and BD in terms of inflammation biomarkers. "
2.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2021 - "Using untargeted proteomic profiling of circulating proteins from individuals in two independent cohorts with type 1 and type 2 diabetes and varying stages of DKD followed for 7 to 15 years, we identified three elevated plasma proteins-fibroblast growth factor 20 (OR, 0.69; 95% CI, 0.54 to 0.88), angiopoietin-1 (OR, 0.72; 95% CI, 0.57 to 0.91), and tumor necrosis factor ligand superfamily member 12 (OR, 0.75; 95% CI, 0.59 to 0.95)-that were associated with protection against progressive renal decline and progression to ESRD. "
3.	Type 2 Diabetes Mellitus (MODY) 01/01/2021 - "Using untargeted proteomic profiling of circulating proteins from individuals in two independent cohorts with type 1 and type 2 diabetes and varying stages of DKD followed for 7 to 15 years, we identified three elevated plasma proteins-fibroblast growth factor 20 (OR, 0.69; 95% CI, 0.54 to 0.88), angiopoietin-1 (OR, 0.72; 95% CI, 0.57 to 0.91), and tumor necrosis factor ligand superfamily member 12 (OR, 0.75; 95% CI, 0.59 to 0.95)-that were associated with protection against progressive renal decline and progression to ESRD. "
4.	Mania (Manias) 11/01/2017 - "Serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels of patients with bipolar disorder in manic episode, in remission and healthy controls."
5.	Inflammation (Inflammations) 04/01/2008 - "The cytokine TWEAK modulates renal tubulointerstitial inflammation." 06/01/2007 - "TWEAK cytokine has been implicated in several biological responses including inflammation, angiogenesis, and osteoclastogenesis. " 01/01/2016 - "The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily and are upregulated in tissue injury to mediate local tissue responses including inflammation and tissue remodeling. " 11/19/2021 - "Here, we show that mice having a keratinocyte-specific deletion of Fn14 (Tnfrsf12a), the receptor for the TNF superfamily cytokine TWEAK (Tnfsf12), displayed reduced imiquimod-induced skin inflammation, including diminished epidermal hyperplasia and less expression of psoriasis signature genes. " 01/01/2021 - "The aim of this study was to investigate the serum TNF-related weak inducer of apoptosis (TWEAK) and TNF-related apoptosis-inducing ligand (TRAIL) levels in patients with bipolar depression (BD), MDD and a healthy control (HC) group to determine any differences between MDD and BD in terms of inflammation biomarkers. "

Related Drugs and Biologics

1.	TNF-Related Apoptosis-Inducing Ligand
2.	Fibroblast Growth Factors (Fibroblast Growth Factor)
3.	Proteins (Proteins, Gene)
4.	Angiopoietin-1
5.	Blood Proteins (Serum Proteins)
6.	Biomarkers (Surrogate Marker)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
9.	TWEAK Receptor
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics