Fatty Acid Binding Protein 3

A small cytosolic fatty-acid binding protein that forms a lipid-binding beta-barrel structure and is expressed by CARDIOMYOCYTES and at lower levels in brain tissue. It is released into plasma immediately following cardiac injury and may therefore serve as a useful biomarker for the early detection of MYOCARDIAL INFARCTION.

Also Known As:

Networked: 489 relevant articles (9 outcomes, 109 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kubota, Isao: 18 articles (02/2018 - 02/2005)
2.	Arimoto, Takanori: 15 articles (02/2018 - 02/2005)
3.	Watanabe, Tetsu: 13 articles (02/2018 - 02/2007)
4.	Lichtenauer, Michael: 12 articles (02/2022 - 09/2017)
5.	Sanchez, Jean-Charles: 11 articles (03/2022 - 01/2004)
6.	Paar, Vera: 11 articles (02/2022 - 09/2017)
7.	Miyamoto, Takuya: 11 articles (02/2018 - 02/2005)
8.	Shishido, Tetsuro: 11 articles (02/2018 - 07/2005)
9.	Fukunaga, Kohji: 10 articles (03/2022 - 02/2010)
10.	Hoppe, Uta C: 10 articles (02/2022 - 09/2017)

Related Diseases

1.	Chest Pain (Chest Pains) 10/01/2011 - "In a study of 677 patients admitted to the emergency department (ED) for chest pain, we found that a semiquantitative point-of-care test that detects h-FABP (Cardiodetect(®)) had low sensitivity for the prediction of ACS. " 01/01/2010 - "In this study on a large cohort of patients admitted to an ED for chest pain, IMA and h-FABP did not provide valuable information for ACS diagnosis." 01/01/2022 - "(1) The levels of Copeptin, H-FABP and cTnI in AMI patients were evidently higher than those in non-AMI patients with chest pain. " 10/01/2017 - "We analysed the diagnostic value of h-FABP and hs-TnI in patients presenting to ED with chest pain and no cTnI elevations. " 10/01/2016 - "In a nested prospective cohort study including adult patients with suspected cardiac chest pain, venous blood samples were tested for h-FABP (FABPulous BV) on arrival and 3h later. "
2.	Myocardial Infarction 03/01/2000 - "In this study we investigated the clinical validity of H-FABP as a biochemical diagnostic marker in the early phase of acute myocardial infarction (AMI). " 01/01/2023 - "Retracted: Diagnostic Value of Echocardiography Combined with Serum h-FABP and cTnI in Myocardial Infarction and Its Evaluation Value in Left Ventricular Function." 01/01/2022 - "H-FABP as a diagnostic marker for early detection of young myocardial infarction among Indians." 01/01/2022 - "Patients with myocardial infarction show high levels of h-FABP and cTnI, and CDE plus the detection of serum h-FABP and cTnI levels can significantly improve the detection accuracy and effectively evaluate the left ventricular function of patients with myocardial infarction, with a certain predictive value for cardiac function grading in myocardial infarction." 01/01/2022 - "The levels of serum h-FABP and cTnI in patients with myocardial infarction increased with the increase of cardiac function grades (P < 0.05). "
3.	Acute Coronary Syndrome 01/01/2010 - "This study evaluates the diagnostic accuracy and the clinical utility of h-FABP and IMA for non-ST-segment elevation acute coronary syndrome (ACS) diagnosis in the first hour of management in an ED. " 08/08/2006 - "We measured H-FABP in 2287 patients with acute coronary syndromes from the OPUS-TIMI 16 trial. " 01/01/2019 - "Role of Gal-3 and H-FABP in the early diagnosis of acute coronary syndrome." 08/01/2018 - "Diagnostic and prognostic value of H-FABP in acute coronary syndrome: Still evidence to bring." 08/01/2016 - "In patients suspected of acute coronary syndrome presenting to the emergency department, H-FABP testing improves diagnostic accuracy in addition to clinical findings and electrocardiography. "
4.	Cardiovascular Diseases (Cardiovascular Disease) 10/01/2022 - "Whether measurement of H-FABP improves cardiovascular disease risk prediction in these patients warrants further studies." 09/14/2022 - "The Role of Fatty Acid Binding Protein 3 in Cardiovascular Diseases." 01/01/2018 - "ACS patients positive for H-FABP had higher rates in cardiac events and mortality. " 05/26/2017 - "Kaplan-Meier analysis demonstrated that the combination of high H-FABP levels and QRS prolongation could be used to reliably stratify patients at high risk for cardiac events (log rank test P < 0.0001). " 05/26/2017 - "Multivariate analysis demonstrated that high H-FABP levels [hazard ratio (HR) = 1.745, P = 0.021] and QRS prolongation (HR 1.612, P = 0.0258) were independent predictors of cardiac events. "
5.	Inflammation (Inflammations) 10/01/2023 - "The level of H-FABP indicates not only CVD damage but is a valuable measure for patients with increased inflammation disease comorbidities." 05/01/2015 - "H-FABP protects cardiomyocytes from LPS-induced inflammation and cell injury." 05/01/2015 - "In contrast, when H-FABP was overexpressed by pcDNA3.1-H-FABP transfection, the LPS-induced inflammation and cell damage were suppressed. " 08/25/1999 - "The LPS-induced decrease in L-FABP and H-FABP may be an additional mechanism contributing to the decrease in FA oxidation that is associated with the host response to infection and inflammation." 01/01/2023 - "Loss of fatty acid binding protein 3 ameliorates lipopolysaccharide-induced inflammation and endothelial dysfunction."

Related Drugs and Biologics

1.	Fatty Acid-Binding Proteins
2.	Myoglobin
3.	Fatty Acid Binding Protein 3
4.	Biomarkers (Surrogate Marker)
5.	Troponin T (Troponin T1)
6.	Troponin I
7.	MB Form Creatine Kinase
8.	Proteins (Proteins, Gene)
9.	5S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acid
10.	Lipopolysaccharides

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Therapeutics
3.	Off-Pump Coronary Artery Bypass (Coronary Artery Bypass, Off Pump)
4.	Patient Readmission
5.	Drug Therapy (Chemotherapy)