Dynactin Complex

A multi-subunit protein of EUKARYOTIC CELLS. It functions in bidirectional intracellular transport of ORGANELLES and CYTOPLASMIC VESICLES by linking them to DYNEIN and KINESIN.

Also Known As:

150 kDa Dynein-Associated Protein; Dynactin; Dynactin 1; Dynactin Subunit 1; Dynactin Subunit 2; Dynactin Subunit 3; Dynactin Subunit 4; Dynactin-2; Dynactin-3; Dynactin-4; Dynactins; Dynamitin Protein; Dynein Activator Protein; Dynein-Associated Protein, 150-kDa; p150(Glued); p22 Dynactin Light Chain; p50 Dynamitin; 150 kDa Dynein Associated Protein; 150-kDa Dynein-Associated Protein; Dynactin 2; Dynactin 3; Dynactin 4; Dynamitin, p50; Dynein Associated Protein, 150 kDa

Networked: 114 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Holzbaur, Erika L F: 8 articles (07/2013 - 05/2002)
2.	Wallace, Karen E: 5 articles (07/2008 - 05/2002)
3.	Dupuis, Luc: 4 articles (04/2015 - 06/2007)
4.	Ludolph, Albert C: 4 articles (04/2015 - 11/2005)
5.	LaMonte, Bernadette H: 4 articles (02/2006 - 05/2002)
6.	Mishima, Takayasu: 3 articles (01/2021 - 08/2014)
7.	Tsuboi, Yoshio: 3 articles (01/2021 - 08/2014)
8.	Oh, Shin J: 3 articles (08/2017 - 04/2003)
9.	Wong, Philip C: 3 articles (04/2015 - 02/2008)
10.	Hoogenraad, Casper C: 3 articles (01/2015 - 09/2008)

Related Diseases

1.	Motor Neuron Disease (Primary Lateral Sclerosis) 01/01/2022 - "Identification of quantitative trait loci for survival in the mutant dynactin p150Glued mouse model of motor neuron disease." 10/01/2021 - "elegans dynactin subunit DNC-1, which corresponds to G59S in human p150Glued that causes motor neuron disease. " 01/01/2015 - "This model is based on an autosomal dominant lower motor neuron disease in humans linked to a mutation in the p150Glued subunit of the dynactin complex. " 01/01/2015 - "Genetic background effects on disease onset and lifespan of the mutant dynactin p150Glued mouse model of motor neuron disease." 06/01/2011 - "This includes notably mutations in the P150Glued subunit of dynactin that are found in Perry syndrome and motor neuron diseases. "
2.	Parkinsonian Disorders (Parkinsonism) 05/01/2013 - "The dynactin p150 subunit: cell biology studies of sequence changes found in ALS/MND and Parkinsonian syndromes." 08/01/2014 - "DCTN1 mutations may contribute to disparate neurodegenerative diagnoses, including familial motor neuron disease, parkinsonism, and frontotemporal atrophy, and further studies of dynactin-mediated cargo transport may prove insightful." 01/01/2020 - "Perry syndrome, also recognized as Perry disease, is a rare autosomal dominant disorder characterized by midlife-onset atypical parkinsonism, apathy or depression, respiratory failure and weight loss caused by a mutation in the Dynactin (DCTN1) gene. " 08/01/2017 - "Perry syndrome is a rare atypical parkinsonism with depression, apathy, weight loss, and central hypoventilation caused by mutations in dynactin p150glued (DCTN1). " 04/15/2015 - "Mutations in components of the molecular motor dynein/dynactin lead to neurodegenerative diseases of the motor system or atypical parkinsonism. "
3.	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 05/20/2008 - "In concert with its binding partners, adenomatous polyposis coli and p150(glued), EB1 plays a crucial role in a variety of microtubule-based cellular processes. " 09/07/2005 - "In eukaryotic cells, the adenomatous polyposis coli/Kar9p and dynein/dynactin pathways are involved in guiding MT plus ends and MT sliding along the cortex, respectively. " 12/12/2003 - "Human EB1 family proteins, which include EB1, EBF3, and RP1, also associate with the tumor suppressor protein adenomatous polyposis coli (APC) and p150glued, a component of the dynactin complex. " 05/01/2013 - "Forced Akt activation increased the binding of the microtubule-associated protein adenomatous polyposis coli (APC), the APC-binding protein end-binding protein 1 (EB1) and dynactin, a dynein activator complex, with microtubules. " 07/22/2002 - "A subset of microtubule-associated proteins, including cytoplasmic linker protein (CLIP)-170, dynactin, EB1, adenomatous polyposis coli, cytoplasmic dynein, CLASPs, and LIS-1, has been shown recently to target to the plus ends of microtubules. "
4.	Glioma (Gliomas) 01/01/2021 - "This present study aims to investigate the potential prognostic values of dynactin genes (DCTN) for predicting the overall survival (OS) in low-grade glioma (LGG) patients. " 01/01/2021 - "Study on the Prognostic Values of Dynactin Genes in Low-Grade Glioma." 05/01/2007 - "Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation."
5.	Thymoma (Thymic Carcinoma) 01/01/2016 - "Here, we have performed a prospective nationwide genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 (DCTN4), retinoic acid early transcript 1E (RAET1E), and V-akt murine thymoma viral oncogene homolog 3 (AKT3) to be associated with unfavourable outcome in patients with pneumococcal meningitis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
3.	cytoplasmic linker protein 170 (restin)
4.	Tretinoin (Retinoic Acid)
5.	Glycine (Aminoacetic Acid)
6.	Dyneins (Dynein)
7.	Dynactin Complex
8.	Cytoplasmic Dyneins
9.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
10.	Carrier Proteins (Binding Protein)

Related Therapies and Procedures

1.	Transjugular Intrahepatic Portasystemic Shunt
2.	Therapeutics
3.	Surgical Instruments (Clip)