Regulatory Factor X Transcription Factors

A family of eukaryotic transcription factors that recognize and bind to a highly-conserved cis-regulatory sequence (X-box) within the promoter region of MHC CLASS II GENES. They contain a conserved winged-helix DNA binding domain and function as homo or heterodimers.

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Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bieder, Andrea: 1 article (10/2016)
2.	Burghoorn, Jan: 1 article (10/2016)
3.	Castrén, Eero: 1 article (10/2016)
4.	Hokkanen, Marie-Estelle: 1 article (10/2016)
5.	Kere, Juha: 1 article (10/2016)
6.	Lauter, Gilbert: 1 article (10/2016)
7.	Sugiaman-Trapman, Debora: 1 article (10/2016)
8.	Swoboda, Peter: 1 article (10/2016)
9.	Tammimies, Kristiina: 1 article (10/2016)
10.	Tapia-Páez, Isabel: 1 article (10/2016)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2023 - "The progressive oxidative phosphorylation deficiency in astrocytes induces FOXJ1 and RFX transcription factors, known as master regulators of motile ciliogenesis. "
2.	Dyslexia (Alexia) 10/01/2016 - "Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X-box promoter motifs."
3.	Ciliopathies 05/01/2014 - "Regulatory Factor X (RFX) transcription factors are important for development and are likely involved in the pathogenesis of serious human diseases including ciliopathies. "

Related Drugs and Biologics

1.	Regulatory Factor X1