Bilateral Vestibulopathy

Impairment of the vestibular function of both inner ears which can cause difficulties with balance, gait, VERTIGO, and visual blurring.

Also Known As:

Bilateral Vestibular Deficiency; Bilateral Vestibular Insufficiency; Bilateral Vestibular Loss; Vestibular Areflexia; Vestibular Deficiency, Bilateral; Vestibular Insufficiency, Bilateral; Vestibular Loss, Bilateral; Vestibulopathy, Bilateral

Networked: 81 relevant articles (9 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Vestibular Neuronitis (Vestibular Neuritis)
2.	Ototoxicity
3.	Cerebellar Ataxia (Dysmetria)
4.	Cognitive Dysfunction
5.	Vertigo (Positional Vertigo)

Experts

1.	Smith, Paul F: 6 articles (01/2018 - 01/2008)
2.	Kingma, Herman: 4 articles (01/2020 - 02/2010)
3.	Fridman, Gene Y: 4 articles (12/2019 - 11/2012)
4.	Della Santina, Charles C: 4 articles (11/2019 - 11/2012)
5.	MacDougall, Hamish G: 4 articles (01/2018 - 06/2006)
6.	Zheng, Yiwen: 4 articles (12/2016 - 01/2008)
7.	Brandt, Thomas: 4 articles (04/2015 - 08/2005)
8.	Guyot, Jean-Philippe: 3 articles (01/2020 - 03/2011)
9.	Strupp, Michael: 3 articles (02/2013 - 08/2005)
10.	Brandt, T: 3 articles (12/2008 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Bilateral Vestibulopathy:

1.	Gentamicins (Gentamicin)FDA LinkGeneric 08/01/2022 - "We interpreted these findings as signs of both severe peripheral bilateral vestibulopathy and cerebellar and/or midbrain late-onset neurotoxicity, which can be explained by the intrinsic neurotoxic capability of high doses of gentamicin in the CNS." 11/01/2013 - "Gentamicin-induced bilateral vestibulopathy in rabbits: vestibular dysfunction and histopathology." 06/18/2012 - "To review patients with severe bilateral vestibular loss associated with gentamicin treatment in hospital. " 09/01/2011 - "To report the little known fact that systemically administered gentamicin can cause severe unilateral, rather than only bilateral vestibular loss. " 04/21/2009 - "Head impulse testing is useful for early bedside detection of gentamicin vestibulotoxicity because most patients, even those with partial bilateral vestibular loss (BVL), have large overt saccades. "
2.	AminoglycosidesIBA 01/01/2018 - "oVEMP abnormalities were found more frequent in aminoglycoside-related bilateral vestibular loss (BVL) compared with Menière's disease (91.7 vs. 54.6%, p = 0.039). " 08/01/2009 - "We aimed to determine the early efficacy of vestibular rehabilitation with electrotactile vestibular substitution system (EVSS) as a new treatment modality in patients with bilateral vestibular loss due to aminoglycoside-induced ototoxicity. " 03/15/2022 - "Discussion In the studies reviewed, disease-specific patterns could be recognized in different patient cohorts, with anterior-canal sparing being a hallmark feature in aminoglycoside-related bilateral vestibulopathy, Menière's disease and vestibular Schwannoma. " 12/12/2008 - "We sequenced the 12S rRNA of 66 patients with bilateral vestibulopathy (BV) with (n=15) or without (n=51) prior exposure to aminoglycosides, as well as 155 healthy controls with intact vestibular function (sport pilots), and compared these to 2704 published sequences (Human Mitochondrial Genome Database). " 12/12/2008 - "Mitochondrial 12S rRNA susceptibility mutations in aminoglycoside-associated and idiopathic bilateral vestibulopathy."
3.	IronIBA 01/01/2021 - "This study aimed to determine the protective effects of deferoxamine, an iron-chelating agent, on vestibulotoxicity using an intratympanic gentamicin injection (ITGM)-induced bilateral vestibulopathy rat model. "
4.	Deferoxamine (Desferal)FDA LinkGeneric 01/01/2021 - "Protective Effects of Deferoxamine on Vestibulotoxicity in Gentamicin-Induced Bilateral Vestibulopathy Rat Model." 01/01/2021 - "This study aimed to determine the protective effects of deferoxamine, an iron-chelating agent, on vestibulotoxicity using an intratympanic gentamicin injection (ITGM)-induced bilateral vestibulopathy rat model. "
5.	Chelating AgentsIBA 01/01/2021 - "This study aimed to determine the protective effects of deferoxamine, an iron-chelating agent, on vestibulotoxicity using an intratympanic gentamicin injection (ITGM)-induced bilateral vestibulopathy rat model. "
6.	Carbamazepine (Tegretol)FDA LinkGeneric 02/01/2013 - "Although progress has been made in the diagnosis and treatment of most peripheral vestibular disorders, more state-of-the-art trials are needed on the treatment of bilateral vestibulopathy to prove the efficacy of balance training, of vestibular neuritis (in terms of recovery of peripheral vestibular function and central compensation), of vestibular paroxysmia to prove the effects of carbamazepine, and of Menière's disease to find the optimal dosage of betahistine."
7.	Betahistine (Serc)IBA 02/01/2013 - "Although progress has been made in the diagnosis and treatment of most peripheral vestibular disorders, more state-of-the-art trials are needed on the treatment of bilateral vestibulopathy to prove the efficacy of balance training, of vestibular neuritis (in terms of recovery of peripheral vestibular function and central compensation), of vestibular paroxysmia to prove the effects of carbamazepine, and of Menière's disease to find the optimal dosage of betahistine."
8.	ABF systemIBA 03/01/2007 - "The aim of this study was to determine the relative effectiveness of an ABF system to reduce postural sway in stance in healthy control subjects and in subjects with bilateral vestibular loss, under conditions of reduced vestibular, visual, and somatosensory inputs. " 07/01/2005 - "To evaluate the effectiveness of an audio-biofeedback (ABF) system for improving balance in patients with bilateral vestibular loss (BVL). "
9.	Capsules (Microcapsules)IBA 01/01/2017 - "This review will address the recent epidemiological/survey studies that link vestibular dysfunction with cognitive impairment in the elderly; recent clinical investigations into cognitive impairment in the context of vestibular dysfunction, both in the elderly and in the cases of otic capsule dehiscence and partial bilateral vestibulopathy; recent evidence that vestibular impairment is associated with hippocampal atrophy; and finally recent evidence relating to the hypothesis that vestibular dysfunction could be a risk factor for dementia. "
10.	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/01/2018 - "Objective: The aim of this study was to investigate the impact of a rotating sound stimulation on the postural performances in normal subjects, patients with bilateral vestibulopathy (BVP), unilateral (UCI), and bilateral (BCI) cochlear implantees. "

Therapies and Procedures

1.	Prostheses and Implants (Prosthesis) 01/01/2012 - "We tested a one-dimensional, unilateral prosthesis in a rhesus monkey with bilateral vestibular loss and found that chronic electrical stimulation partially restored the compensatory VOR and also that percepts of head orientation relative to gravity were improved. " 02/01/2009 - "Evaluate the effectiveness of a head-mounted vibrotactile prosthesis for balance improvement in subjects with severe bilateral vestibular loss (BVL). " 11/01/2012 - "Progress toward development of a multichannel vestibular prosthesis for treatment of bilateral vestibular deficiency." 01/01/2012 - "Rotational cues in patients that suffer from bilateral vestibular loss can be delivered by vestibular prosthesis. " 01/01/2012 - "Patients with bilateral vestibular loss experience dehabilitating visual, perceptual, and postural difficulties, and an implantable vestibular prosthesis that could improve these symptoms would be of great benefit to these patients. "
2.	Psychology Biofeedback (Biofeedback) 01/01/2005 - "We investigated whether long-term bilateral vestibular loss subjects could combine auditory biofeedback of trunk sway with their remaining natural sensory inputs on balance to provide an improved control of trunk sway. " 03/01/2012 - "This study explores the effect of vibrotactile biofeedback on gait in 20 patients with bilateral vestibular areflexia using observational gait analysis to score individual balance. " 06/07/2010 - "The present study evaluated the effectiveness of electrotactile tongue biofeedback (BrainPort((R))) as a sensory substitute for the vestibular apparatus in patients with bilateral vestibular loss (BVL) who did not have a good response to conventional vestibular rehabilitation (VR). " 02/01/2010 - "Inter-individual and test-retest variability without biofeedback was assessed in 10 additional patients with bilateral vestibular areflexia. " 07/01/2005 - "Audio-biofeedback improves balance in patients with bilateral vestibular loss."
3.	Physical Therapy Modalities (Physical Therapy Technique) 10/01/2001 - "The purpose of the study was to assess the efficacy of physical therapy for patients with bilateral vestibular loss. " 10/01/2001 - "Many patients with bilateral vestibular loss benefit from an individualized vestibular physical therapy exercise program based on improved physical function and reduced self-perceived levels of handicap." 10/01/2001 - "Physical therapy outcomes for persons with bilateral vestibular loss."
4.	Denervation 01/01/2023 - "In this case report, it was described how a woman, who previously underwent a neurectomy of the left vestibular nerve and suffers from bilateral vestibulopathy (BVP), reported improved balance whenever her CI on the left was stimulating. " 01/01/2018 - "VVOR gain and vestibulo-ocular reflex (VOR) gain were analyzed with the data obtained from 35 subjects divided into four groups: healthy (N = 10), unilateral vestibular with vestibular neurectomy (N = 8), bilateral vestibulopathy (N = 12), and cerebellar ataxia, neuropathy, and vestibular areflexia syndrome (CANVAS) (N = 5). " 01/01/2017 - "Sweat Gland Denervation in Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)." 01/01/2018 - "We also used the μVEMP device to record VEMP responses from six patients (6 females, age mean±SD: 50.3 ± 20.8 years) with classical peripheral audio-vestibular diseases (unilateral vestibular neuritis, unilateral neurectomy, bilateral vestibular loss, unilateral superior canal dehiscence, unilateral otosclerosis). "
5.	Cognitive Training 01/01/2018 - "We propose that cognitive training is a promising way to alleviate the debilitating symptoms of patients with complete bilateral vestibular loss (BVP), who often fail to show improvement when relying solely on conventional treatment methods. " 01/01/2023 - "In addition, cognitive rehabilitation methods are currently being developed, which presumably can also improve compensation for bilateral vestibular loss. "