Histone H2a Dioxygenase AlkB Homolog 1

A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS.

Also Known As:

AlkB Homolog 1, Histone H2a Dioxygenase; ALKBH Protein; Alkylated DNA Repair Protein AlkB Homolog 1; Alpha-Ketoglutarate-Dependent Dioxygenase ABH1; DNA Lyase ABH1; DNA Oxidative Demethylase ALKBH1; ABH1, Alpha-Ketoglutarate-Dependent Dioxygenase; ABH1, DNA Lyase; Alpha Ketoglutarate Dependent Dioxygenase ABH1

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Dioxygenases: 495
        AlkB Enzymes: 4
        Histone H2a Dioxygenase AlkB Homolog 1: 1
        human ALKBH1 protein
        mouse Alkbh1 protein
  - DNA Repair Enzymes: 492
    - AlkB Enzymes: 4
      - Histone H2a Dioxygenase AlkB Homolog 1: 1
        human ALKBH1 protein
        mouse Alkbh1 protein

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/01/2023 - "Here, we find that the m1 A demethylase alkB homolog 1, histone H2A dioxygenase (ALKBH1) is overexpressed in CRC and is associated with metastasis and poor prognosis. "