Autophagy-Related Protein 7

An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.

Also Known As:

ATG12-Activating Enzyme E1 ATG7; ATG7 Protein; Ubiquitin-Activating Enzyme E1-like Protein; Ubiquitin-Like Modifier-Activating Enzyme ATG7; ATG12 Activating Enzyme E1 ATG7; Autophagy Related Protein 7; Ubiquitin Activating Enzyme E1 like Protein; Ubiquitin Like Modifier Activating Enzyme ATG7

Networked: 27 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Autophagy-Related Proteins: 555
    - Autophagy-Related Protein 7: 27

Experts

1.	Fu, Lin: 1 article (03/2022)
2.	Guo, Jun: 1 article (03/2022)
3.	Liu, Haojie: 1 article (03/2022)
4.	Bian, Shuai: 1 article (01/2022)
5.	Li, Fangyu: 1 article (01/2022)
6.	Liu, Meichen: 1 article (01/2022)
7.	Lu, Shuyan: 1 article (01/2022)
8.	Ren, Limei: 1 article (01/2022)
9.	Wang, Jiawen: 1 article (01/2022)
10.	Wang, Siming: 1 article (01/2022)

Related Diseases

1.	Ischemia 09/01/2015 - "Treatment with Atg7 siRNA: 1) reduced Atg7 protein expression in the cerebellum by 56%; 2) prevented the typical ischemia-induced formation of LC3-II in the cerebellum 24h after asphyxial cardiac arrest; 3) improved performance on the beam-balance apparatus on days 1-5; and 4) increased calbindin-labeled Purkinje cell survival assessed on day 14. "
2.	Heart Arrest (Cardiac Arrest) 09/01/2015 - "Treatment with Atg7 siRNA: 1) reduced Atg7 protein expression in the cerebellum by 56%; 2) prevented the typical ischemia-induced formation of LC3-II in the cerebellum 24h after asphyxial cardiac arrest; 3) improved performance on the beam-balance apparatus on days 1-5; and 4) increased calbindin-labeled Purkinje cell survival assessed on day 14. "
3.	Retinal Degeneration 03/01/2022 - "In our study, chronically elevated IOP caused anterograde axonal transport (AAT) defect, increased the autophagic activity (manifested by significantly (p < 0.05) increased LC3-II/LC3-I ratio, beclin-1 and Atg7 protein expressions) and also downmodulated the protein expression of p-Akt and p-mTOR, mediated by the purinergic P2 receptor subtype 7 (P2X7) upmodulation-leading to retinal degeneration. " 08/11/2010 - "Light-dependent retinal degeneration in the Drosophila visual system is caused by the knockdown or mutation of autophagy-essential components, such as autophagy-related protein 7 and 8 (atg-7/atg-8), or genes essential for PE (phosphatidylethanolamine) biogenesis and autophagosome formation, including Phosphatidylserine decarboxylase (Psd) and CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (Ept). "
4.	Non-alcoholic Fatty Liver Disease 01/10/2023 - "The aim of this study was to analyze hepatic ATG7 mRNA and ATG7 protein expression regarding obesity-associated NAFLD. " 01/10/2023 - "Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity."
5.	Obesity 01/10/2023 - "The aim of this study was to analyze hepatic ATG7 mRNA and ATG7 protein expression regarding obesity-associated NAFLD. " 01/10/2023 - "Increased Hepatic ATG7 mRNA and ATG7 Protein Expression in Nonalcoholic Steatohepatitis Associated with Obesity."

Related Drugs and Biologics

1.	Calbindins
2.	Small Interfering RNA (siRNA)
3.	Proteins (Proteins, Gene)
4.	Messenger RNA (mRNA)
5.	Beclin-1
6.	Purinergic P2 Receptors (ADP Receptor)
7.	Photosensitizing Agents (Photosensitizers)
8.	MicroRNAs (MicroRNA)
9.	Inflammasomes
10.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)