Rotator Cuff Injuries

Injuries to the ROTATOR CUFF of the shoulder joint.

Also Known As:

Glenoid Labral Tears; Rotator Cuff Tears; Rotator Cuff Tendinitis; Rotator Cuff Tendinosis; Cuff Injury, Rotator; Glenoid Labral Tear; Injury, Rotator Cuff; Labral Tear, Glenoid; Labral Tears, Glenoid; Rotator Cuff Injury; Rotator Cuff Tear; Rotator Cuff Tendinitides; Rotator Cuff Tendinoses; Tear, Glenoid Labral; Tear, Rotator Cuff; Tears, Rotator Cuff; Tendinitis, Rotator Cuff; Tendinoses, Rotator Cuff; Tendinosis, Rotator Cuff

Networked: 1873 relevant articles (143 outcomes, 357 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426

Related Diseases

1.	Pain (Aches)
2.	Tendinopathy (Tendonitis)
3.	Shoulder Pain
4.	Bursitis (Adhesive Capsulitis)
5.	Arthritis (Polyarthritis)

Experts

1.	Maffulli, Nicola: 24 articles (03/2020 - 08/2007)
2.	Lee, Thay Q: 21 articles (01/2022 - 09/2007)
3.	Gerber, Christian: 20 articles (04/2022 - 11/2006)
4.	Romeo, Anthony A: 20 articles (12/2020 - 02/2004)
5.	Mihata, Teruhisa: 19 articles (10/2021 - 03/2011)
6.	Denaro, Vincenzo: 19 articles (01/2020 - 08/2007)
7.	Longo, Umile Giuseppe: 17 articles (01/2020 - 08/2007)
8.	Millett, Peter J: 16 articles (04/2022 - 12/2015)
9.	Feeley, Brian T: 15 articles (01/2022 - 04/2012)
10.	Rhee, Yong Girl: 14 articles (04/2022 - 06/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rotator Cuff Injuries:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/30/2020 - "This study tested the hypothesis that treatment of symptomatic, partial-thickness rotator cuff tears (sPTRCT) with fresh, uncultured, unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) isolated from lipoaspirate at the point of care is safe and more effective than corticosteroid injection. " 04/01/2017 - "This study shows that the addition of PRP does not interfere with the anti-inflammatory effects of a corticosteroid on IL-1β-treated tenocytes from degenerative rotator cuff tears but that it does avoid the deleterious side effects of a corticosteroid. " 01/01/2017 - "We systematically searched seven electronic databases for randomized controlled trials of corticosteroid injection for rotator cuff tendinosis compared with a placebo injection. " 11/07/2023 - "Management of partial-thickness rotator cuff tears with autologous adipose-derived regenerative cells is safe and more effective than injection of corticosteroid." 04/03/2023 - "PRP injection has the potential to successfully treat rotator cuff tears as an alternative to corticosteroids in the long term, in terms of either therapeutic efficiency or adverse effects, followed by SH injection. "
2.	CollagenIBA 01/01/2008 - "The use of porcine dermal collagen as an augmentation graft in the treatment of massive rotator cuff tears is safe and, in most patients, is associated with improved clinical outcome. " 08/01/2021 - "Final results from this 2-year prospective study indicate that the use of this resorbable bovine collagen implant for isolated bioinductive repair of intermediate- and high-grade partial-thickness rotator cuff tears of the supraspinatus is safe and effective, regardless of tear grade and location." 02/01/2018 - "Arthroscopic implantation of a bioinductive collagen scaffold is a safe and effective treatment for intermediate- to high-grade partial-thickness rotator cuff tears of the supraspinatus tendon." 04/01/2023 - "This study was conducted to investigate whether the use of resorbable bioinductive collagen implant (RBI) in addition to conventional rotator cuff repair (conventional RCR) is cost-effective when compared to conventional RCR alone, in the treatment of full-thickness rotator cuff tears (FT RCT). " 04/01/2023 - "Resorbable Bioinductive Collagen Implant Is Cost Effective in the Treatment of Rotator Cuff Tears."
3.	Capsules (Microcapsules)IBA 01/01/2022 - "Specifically, superior capsule reconstruction augmentation of such rotator cuff tears may lead to good outcomes. " 01/01/2020 - "Superior capsule reconstruction for the treatment of irreparable rotator cuff tears leads to improvement in function. " 08/01/2017 - "In particular, superior capsule reconstruction has been reported as a safe and effective method to treat a massive, irreparable rotator cuff tear. " 01/01/2016 - "When superior capsule reconstruction is performed for irreparable rotator cuff tears, acromioplasty may help to decrease the postoperative risk of abrasion and tearing of the graft beneath the acromion." 12/01/2023 - "In this study, we investigated the effects of AGEs on the tissues of the shoulder joint (such as rotator cuff synovium, and capsule) in patients with DM having rotator cuff tears. "
4.	SteroidsIBA 11/27/2023 - "Therefore, the aim of this multi-center, single-blinded, randomized, parallel-group, superiority study is to compare the efficacy of MUA versus intra-articular steroid injection in the treatment of FS patients with a diagnosis of rotator cuff injury or tear by MRI. " 11/01/1981 - "Previous studies have cast doubt on the efficacy of intra-articular steroids in the treatment of rotator cuff tears. " 03/31/1984 - "The value of pulsed electromagnetic fields (PEMF) for the treatment of persistent rotator cuff tendinitis was tested in a double-blind controlled study in 29 patients whose symptoms were refractory to steroid injection and other conventional conservative measures. " 01/01/2021 - "Among the conservative approaches of treating full-thickness rotator cuff tear, a combination of steroid injection and physiotherapy is more effective significantly in comparison with either treatment alone. " 11/27/2019 - "The use of steroid injection for treatment of a full-thickness rotator cuff tear is still controversial. "
5.	SolutionsIBA 11/01/2021 - "Open transosseous repair was historically considered the gold-standard surgical solution for rotator cuff tears; however, with advancements in arthroscopic surgery, this procedure was largely replaced by anchor-based techniques. " 01/01/2020 - "Although open transosseous repair was historically used as a gold-standard surgical solution for rotator cuff tears, this procedure was largely replaced by anchor-based techniques because of the advancement of arthroscopic surgery. " 09/01/2022 - "Use of acellular dermal grafts in SCR procedures for irreparable rotator cuff tears remains a viable long-term solution to restore shoulder function." 09/01/2022 - "This technique represents a valid solution for treatment of massive rotator cuff tears resulting safe, easier and cost saving in comparison with other published techniques." 11/01/2021 - "Superior capsular reconstruction (SCR) has recently gained popularity as a surgical solution for patients with massive rotator cuff tears or shoulder pseudoparalysis (PPS). "
6.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 09/01/2022 - "Current clinical practices for treating rotator cuff injuries, including the use of commercially available devices and evolving trends in surgical management have benefited patients while advances in application of stem/progenitor cells, growth factors, and exosomes hold clinical potential. " 01/01/2013 - "The aim of this study was to determine whether addition of plasma rich in growth factors (PRGF) improves functional and structural outcomes after arthroscopic repair of full-thickness rotator cuff tears. " 10/26/2023 - "The Effect of Platelet-Rich Fibrin, Platelet-Rich Plasma, and Concentrated Growth Factor in the Repair of Full Thickness Rotator Cuff Tears." 01/01/2023 - "Bioactive Scaffold With Spatially Embedded Growth Factors Promotes Bone-to-Tendon Interface Healing of Chronic Rotator Cuff Tear in Rabbit Model." 09/01/2022 - "A wide-ranging literature search was performed, and findings related to the socioeconomic impact of rotator cuff tears, the structure-function relationship of rotator cuff bone-tendon-muscle units, pathophysiology of injury, current clinical treatments, recent state-of-the-art advances (stem cells, growth factors, and exosomes) as well as their regulatory approval, and future strategies aimed at engineering bone-tendon-muscle musculoskeletal units are outlined. "
7.	PolymersIBA 01/01/2012 - "The objective of this study was to evaluate the efficacy of fiber-aligned nanofibrous polymer scaffolds as a potential treatment-delivery vehicle in a rat rotator cuff injury model. " 04/01/2013 - "Arthroscopic deployment of a co-polymer biodegradable spacer (balloon) into the sub-acromial space for an irreparable rotator cuff tear was found to be low-risk and simple procedure associated with improvement in shoulder function and low rate of complications. " 02/01/2021 - "Poly-N-acetyl glucosamine (sNAG) polymer has been shown to increase the rate of healing of venous leg ulcers, and use of this material improved tendon-to-bone healing in a rat model of rotator cuff injury. "
8.	Hyaluronic Acid (Hyaluronan)IBA 12/01/2023 - "The study explored the clinical effects of sodium hyaluronate combined with platelet-rich plasma (PRP) injection on rotator cuff injury in arthroscopic repair. " 02/25/2023 - "The purpose of this study was to evaluate the effectiveness of SH (Sodium Hyaluronate) and PRP (Platelet-Rich Plasma) in treating rotator cuff injuries in the shoulder. " 12/01/2023 - "A total of 92 cases with rotator cuff injury were randomly divided into the control group (n = 46, treated with shoulder arthroscopy repair combined with subacromial space injection of sodium hyaluronate) and the experimental group (n = 46, treated with subacromial space injection of autologous PRP on the basis of the treatment in the control group). " 12/01/2023 - "Clinical effects of sodium hyaluronate combined with platelet-rich plasma injection on rotator cuff injury in arthroscopic repair." 10/01/2023 - "The purpose was to determine the effects of human dermal fibroblasts (HDFs) with hyaluronic acid (HA) on tendon-to-bone healing in a rabbit model of chronic rotator cuff tear injury. "
9.	HydrogelsIBA 01/01/2023 - "The addition of the highly concentrated PRP to stem cells-seeded tendon hydrogel improved healing biomechanically after chronic rotator cuff injury in rats compared to control. " 01/01/2022 - "As an effective delivery system, hydrogel scaffolds may improve the healing of RCTs and be a useful treatment for irreparable rotator cuff injuries. " 01/01/2023 - "Assessment of a Synergistic Effect of Platelet-Rich Plasma and Stem Cell-Seeded Hydrogel for Healing of Rat Chronic Rotator Cuff Injuries." 06/01/2021 - "The capability of hydrogels in simultaneously promoting tenogenesis and osteogenesis was further verified in a rat rotator cuff tear model. " 03/01/2021 - "Herein, we investigated KGN-loaded GelMA hydrogel scaffolds with a bone marrow-stimulating technique for the repair of rotator cuff tear. "
10.	Glucose (Dextrose)FDA LinkGeneric 04/01/2009 - "The present study suggests that normal, but in the high range of normal, increasing plasma glucose levels may be a risk factor for rotator cuff tear. " 01/01/2012 - "Preliminary reports introduced the possible role of glucose as a risk factor for rotator cuff tear. " 04/01/2009 - "Patients with rotator cuff tears (Group 1) showed statistically significantly higher fasting plasma glucose levels within the normoglycaemic range (p = 0.007) than patients with meniscal tear (Group 2). " 04/01/2009 - "To determine the plasma glucose levels in non-diabetic patients with rotator cuff tear. " 04/01/2009 - "Higher fasting plasma glucose levels within the normoglycaemic range and rotator cuff tears."

Therapies and Procedures

1.	Tendon Transfer 01/01/2016 - "Shoulder dysfunction in the setting of irreparable rotator cuff tears (RCTs) can be treated successfully with different types of tendon transfer: Latissimus dorsi transfer for irreparable posterosuperior RCTs works best for young, active patients with an intact subscapularis, no pseudoparalysis or previous surgery, and a functioning teres minor.A more anatomical transfer for irreparable posterosuperior RCTs is a lower trapezius transfer, and early results are promising.Isolated" 05/01/2004 - "To find biomechanical evidence for an optimal tendon transfer that will lead to improved treatment of patients with a massive rotator cuff tear." 06/01/2018 - "Arthroscopic-assisted latissimus dorsi tendon transfer (LDTT) has shown promising results with good outcomes in patients with massive rotator cuff tears (MRCTs), as reported by individual studies. " 09/01/2018 - "Patients with irreparable rotator cuff tears treated with Achilles tendon allograft-augmented latissimus dorsi tendon transfer did not experience significant post-operative improvement in patient-reported outcomes. " 10/01/2012 - "Tendon transfers offer good results in patients with massive, irreparable rotator cuff tears. "
2.	Sutures (Suture) 09/01/2017 - "Bridging sutures facilitate consistent and secure fixation in double-row rotator cuff repairs, suggesting that bridging sutures may be beneficial for distributing tension equally among all sutures during double-row repair of rotator cuff tears." 05/01/2013 - "Arthroscopic trans-tendon suture-bridge repair for partial-thickness articular-side rotator cuff tears resulted in significant improvement in function compared with that before the operation." 11/01/2012 - "In arthroscopic suture bridge repair of full-thickness rotator cuff tears, clinical results of both a knotless and a conventional knot-tying group showed improvement without significant difference between the 2 groups. " 04/18/2012 - "Arthroscopic suture-bridge repair of full-thickness rotator cuff tears was followed by a re-tear rate of 15% as seen with imaging and resulted in significant improvement of functional outcomes and clinical results compared with the preoperative findings." 06/01/2010 - "However, sutures of massive rotator cuff tears do not always produce good results. "
3.	Conservative Treatment 01/01/2011 - "According to the results of this study we identified a value of 13 points as a "cut-off" score to predict good results by conservative management of rotator cuff tear. " 01/01/2017 - "Implications for Rehabilitation There is limited evidence that surgery is not more effective in treating rotator cuff tear than conservative treatment alone. " 01/01/2017 - "There is limited evidence that surgery is not more effective in treating rotator cuff tear than conservative treatment alone. " 01/01/2014 - "There is no convincing evidence that surgical treatment is more effective than conservative management and there is no indication for the surgical treatment of asymptomatic rotator cuff tears." 04/01/2009 - "The aim of this study was to investigate the efficacy of conservative treatment in patients with full-thickness rotator cuff tears by using objective and subjective measurements. "
4.	Tenodesis 12/01/2022 - "Alternatively, biceps tenodesis is the first-line treatment option for failed SLAP repairs, and as an index procedure, traditionally has been reserved for middle-aged individuals (>30 years old), patients receiving workers' compensation, nonoverhead athletes, or in those with concomitant rotator cuff tears. " 07/05/2019 - "Large and massive rotator cuff tears (tears > 3 cm) associated with LHBT pathologies benefited from intraarticular or subpectoral tenodesis similarly, with no differences in short- or mid-term results between these two techniques. " 07/05/2019 - "This study aimed to compare clinical and functional outcomes of open subpectoral versus arthroscopic intraarticular tenodesis in patients with repairable rotator cuff tear associated with LHBT degeneration. " 12/01/2016 - "The study was aimed to compare arthroscopic proximal biceps tenodesis and open subpectoral biceps tenodesis in repair of small or medium rotator cuff tears. " 12/01/2010 - "The purpose of this study was to look at the functional outcomes of arthroscopic repair of anterosuperior rotator cuff tears with open biceps tenodesis when indicated. "
5.	Injections 01/01/2016 - "complete rotator cuff tears may be effectively treated with injections, exercise in the short and intermediate terms respectively. " 08/26/2023 - "Research on the use of PRP for intrasubstance partial-thickness rotator cuff tears is lacking, although these tears have unique properties that may increase the efficacy of platelet-rich plasma injections. " 12/25/2020 - "The Efficacy of Injections for Partial Rotator Cuff Tears: A Systematic Review." 01/01/2022 - "The purpose of this paper is to review available studies that look at the effects of adipose stem cell (ASC) injections in the treatment of rotator cuff tears (RCT). " 01/01/2022 - "The purpose of this study is to summarize evidence for the use of adipose stem cell (ASC) injections in the treatment of rotator cuff tears (RCT) and identify future areas of study. "