CELF Proteins

A family of RRM proteins which contain two N-terminal RNA RECOGNITION MOTIF (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 amino acids between the second and third RRM domains. They regulate pre-mRNA ALTERNATIVE SPLICING and also function in RNA EDITING and PROTEIN BIOSYNTHESIS.

Also Known As:

BRUNOL Proteins; Bruno-Like Family Member Proteins; CUG Triplet Repeat, RNA-Binding Proteins; CUG-BP Proteins; CUGBP Proteins; CUGBP, Elav-Like Family Member Proteins; Bruno Like Family Member Proteins; CUG BP Proteins; CUG Triplet Repeat, RNA Binding Proteins; CUGBP, Elav Like Family Member Proteins; Proteins, BRUNOL; Proteins, CELF; Proteins, CUG-BP; Proteins, CUGBP

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lou, Hua: 2 articles (11/2017 - 12/2012)
2.	Ladd, Andrea N: 2 articles (09/2013 - 12/2012)
3.	Chen, Lijuan: 1 article (11/2017)
4.	Gu, Lei: 1 article (11/2017)
5.	Guo, Yuting: 1 article (11/2017)
6.	Ji, Guangju: 1 article (11/2017)
7.	Mao, Yang: 1 article (11/2017)
8.	Tang, Yinglong: 1 article (11/2017)
9.	Wang, Huiwen: 1 article (11/2017)
10.	Wang, Jun: 1 article (11/2017)

Related Diseases

1.	Myotonic Dystrophy (Dystrophia Myotonica) 07/01/2010 - "The first member of the family, CELF1/CUG-BP1, was identified through its role in myotonic dystrophy, type 1. Several recent studies have uncovered the recurrent implication, to various extents, of CELF proteins or of the functionally related muscleblind-like 1 protein in a number of neurological conditions. " 09/01/2013 - "The involvement of CELF proteins in the pathogenesis of a number of neurodegenerative disorders, including myotonic dystrophy, spinocerebellar ataxia, fragile X syndrome, spinal muscular atrophy, and spinal and bulbar muscular atrophy is discussed. " 07/01/2003 - "Disease-related RBPs include the CELF proteins, which are believed to play roles in normal heart and skeletal muscle development and in the pathology of myotonic dystrophy; the Nova autoimmune antigens, which are neuron-specific proteins involved in the pathogenesis of the neurodegenerative syndrome paraneoplastic opsoclonus-myoclonus ataxia; and the alphaCP proteins, which were originally discovered by virtue of their connection to alpha thalassemia. "
2.	Myocardial Infarction 11/10/2017 - "To determine the functions and molecular mechanisms of CELF proteins in MI, an animal model of acute myocardial infarction (AMI) was used in our study. "
3.	X-Linked Bulbo-Spinal Atrophy 09/01/2013 - "The involvement of CELF proteins in the pathogenesis of a number of neurodegenerative disorders, including myotonic dystrophy, spinocerebellar ataxia, fragile X syndrome, spinal muscular atrophy, and spinal and bulbar muscular atrophy is discussed. "
4.	Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome) 07/01/2003 - "Disease-related RBPs include the CELF proteins, which are believed to play roles in normal heart and skeletal muscle development and in the pathology of myotonic dystrophy; the Nova autoimmune antigens, which are neuron-specific proteins involved in the pathogenesis of the neurodegenerative syndrome paraneoplastic opsoclonus-myoclonus ataxia; and the alphaCP proteins, which were originally discovered by virtue of their connection to alpha thalassemia. "
5.	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 09/01/2013 - "The involvement of CELF proteins in the pathogenesis of a number of neurodegenerative disorders, including myotonic dystrophy, spinocerebellar ataxia, fragile X syndrome, spinal muscular atrophy, and spinal and bulbar muscular atrophy is discussed. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antigens