Nerve Agents

09/25/2011 - "Further studies should identify more effective compounds with this action and optimise doses for protection against nerve agent poisoning in vivo."
11/01/2020 - "Therapeutic efficacy of antidotal treatment of acute poisoning by nerve agents is generally assessed by the evaluation of LD50 values of nerve agents over 24 h following poisoning without or with a single administration of antidotal treatment. "
11/01/2017 - "To fully assess the potential of this compound as an effective treatment for nerve agent poisoning, a comprehensive evaluation of its pharmacokinetic (PK) and biodistribution profiles was performed using both intravenous and intramuscular exposure routes. "
11/09/2010 - "The present findings strongly suggest that DPOAEs represent a promising non-invasive tool to predict SRBD occurrence in nerve agent poisoning and to control the efficacy of a neuroprotective treatment."
02/01/2010 - "The increased use of organophosphorus (OP) pesticides and the ever increasing possibility of terror groups using nerve agents underscore a need to develop effective and safe antidotes against OP poisoning. "

11/17/2023 - "GX has been selected for advanced, BARDA-supported phase 3 trials of RSE and nerve agent seizures. "
01/01/2018 - "Toxicity and seizures, two outcomes of nerve agent exposure, have not been fully evaluated for genetic differences, and thus further studies are required to understand baseline strain and selected line differences."
06/01/2012 - "This study is also the first to show the involvement of the mediodorsal thalamus in the control of nerve agent-induced seizures."
01/01/2010 - "The rhinal structures encompassed in this study apparently have critical functions as both control and trigger sites for nerve agent-evoked seizures."
09/24/2007 - "The purpose of the present study was to focus on a similar approach in nerve agent research by reviewing relevant literature to map potential trigger sites and propagation pathways for seizures. "

01/01/2006 - "PB is used for the symptomatic treatment of myasthenia gravis and has been applied as a prophylaxis against nerve agents. "
01/01/2020 - "In the pharmacology, drugs for Alzheimer disease, myasthenia gravis and prophylaxis of poisoning by nerve agents can be mentioned as the relevant applications. "
08/01/1997 - "Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor used routinely in the treatment of myasthenia gravis and recently by the US Army as a prophylactic agent against potential nerve gas attack in the Persian Gulf War. "
07/01/2012 - "The aim of this study was to design and optimize a prolonged release matrix formulation of pyridostigmine bromide, an effective drug in myasthenia gravis and poisoning with nerve gas, using hydrophilic - hydrophobic polymers via D-optimal experimental design. "
07/01/2015 - "Pyridostigmine bromide (PB) is an FDA-approved drug for the treatment of myasthenia gravis and a prophylactic pre-treatment for organophosphate nerve agent poisoning. "

06/01/2006 - "Therefore, a measure of increased levels of AChE and BChE in the lung lavage can be used to determine the chronology of barrier damage as well as the extent of lung injury following exposure to chemical warfare nerve agents."
01/01/2006 - "Development of a microinstillation model of inhalation exposure to assess lung injury following exposure to toxic chemicals and nerve agents in Guinea pigs."
06/01/2014 - "These results suggest that aerosolization of the highly toxic, persistent chemical warfare nerve agent VX results in acute pulmonary toxicity and lung injury in rats."
06/01/2006 - "We developed a microinstillation technique of inhalation exposure to nerve agent VX and assessed lung injury by biochemical analysis of the bronchoalveolar lavage fluid (BALF). "
03/01/2007 - "To develop therapeutics against lung injury and respiratory toxicity following nerve agent VX exposure, we evaluated the protective efficacy of a number of potential pulmonary therapeutics. "

07/22/2022 - "Acute exposure to nerve agents induces status epilepticus (SE), which can cause death or long-term brain damage. "
01/01/2021 - "Refractory and Super-Refractory Status Epilepticus in Nerve Agent-Poisoned Rats Following Application of Standard Clinical Treatment Guidelines."
11/01/2020 - "Acute nerve agent exposure induces status epilepticus (SE), which can cause brain damage or death. "
10/01/2018 - "Acute exposure to nerve agents induces status epilepticus (SE), which causes brain damage or death. "
11/01/2017 - "Acute nerve agent exposure causes prolonged status epilepticus (SE), leading to death or long-term brain damage. "