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microsclerodermin A

structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - microsclerodermin A: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - microsclerodermin A: 1

Experts

1.	Guzmán, Esther A: 1 article (02/2015)
2.	Harmody, Dedra: 1 article (02/2015)
3.	Kemami-Wangun, Hilaire V: 1 article (02/2015)
4.	Maers, Kelly: 1 article (02/2015)
5.	Roberts, Jill: 1 article (02/2015)
6.	Wright, Amy E: 1 article (02/2015)

Related Diseases

1.

Pancreatic Neoplasms (Pancreatic Cancer)

02/01/2015 - "Microsclerodermin A is shown here to inhibit NFκB transcriptional activity in a reporter cell line, to reduce levels of phosphorylated (active) NFκB in the AsPC-1 cell line, to have an IC50 for cytotoxicity in the low micromolar range against the AsPC-1, BxPC-3, MIA PaCa-2 and PANC-1 pancreatic cancer cell lines, and to induce significant apoptosis in the AsPC-1, BxPC-3 and the PANC-1 cell lines. "
02/01/2015 - "The marine natural product microsclerodermin A is a novel inhibitor of the nuclear factor kappa B and induces apoptosis in pancreatic cancer cells."

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)