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methyl 2- (3- ethyl- 9- fluoro- 7a- hydroxy- 8- methoxy- 1,2,3,4,6,7,7a,12,12a,12b- decahydroindolo(2,3- a)quinolizin- 2- yl)- 3- methoxyacrylate

structure in first source

Also Known As:

MGM-16

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Indole Alkaloids: 200
    - Secologanin Tryptamine Alkaloids: 81
      - methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate: 2
    - Indolizines: 3
      - Indolizidines: 2
        Indole Alkaloids: 200
        Secologanin Tryptamine Alkaloids: 81
        methyl 2-(3-ethyl-9-fluoro-7a-hydroxy-8-methoxy-1,2,3,4,6,7,7a,12,12a,12b-decahydroindolo(2,3-a)quinolizin-2-yl)-3-methoxyacrylate: 2

Experts

1.	Devi, Lakshmi A: 1 article (03/2014)
2.	Horie, Syunji: 1 article (03/2014)
3.	Kitajima, Mariko: 1 article (03/2014)
4.	Matsumoto, Kenjiro: 1 article (03/2014)
5.	Misawa, Kaori: 1 article (03/2014)
6.	Muramatsu, Naotaka: 1 article (03/2014)
7.	Nakayama, Terumi: 1 article (03/2014)
8.	Narita, Minoru: 1 article (03/2014)
9.	Suzuki, Tsutomu: 1 article (03/2014)
10.	Takayama, Hiromitsu: 1 article (03/2014)

Related Diseases

1.	Chronic Pain 03/01/2014 - "Systemic administration of MGM-16 produced antinociceptive effects in a mouse acute pain model and antiallodynic effects in a chronic pain model. " 03/01/2014 - "In this study, we developed dual-acting μ- and δ-opioid agonists MGM-15 and MGM-16 from 7-hydroxymitragynine for the treatment of acute and chronic pain. "
2.	Neuralgia (Stump Neuralgia) 03/01/2014 - "These findings suggest that MGM-16 could become a class of a compound with potential therapeutic utility for treating neuropathic pain." 03/01/2014 - "The antiallodynic effect of MGM-16 was completely blocked by β-FNA and naltrindole in a neuropathic pain model. " 04/01/2019 - "Correction to "Orally Active Opioid µ/d Dual Agonist MGM-16, a Derivative of the Indole Alkaloid Mitragynine, Exhibits Potent Antiallodynic Effect on Neuropathic Pain in Mice"." 03/01/2014 - "Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice."
3.	Acute Pain 03/01/2014 - "Systemic administration of MGM-16 produced antinociceptive effects in a mouse acute pain model and antiallodynic effects in a chronic pain model. "

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	7-hydroxymitragynine
3.	Indole Alkaloids
4.	mitragynine
5.	naltrindole