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(Z)- 5- (2,4- dihydroxybenzylidene)thiazolidine- 2,4- dione

has an inhibitory effect on nitric oxide-induced melanogenesis; structure in first source

Also Known As:

MHY498

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidinediones: 2250
      - (Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiazolidinediones: 2250
        (Z)-5-(2,4-dihydroxybenzylidene)thiazolidine-2,4-dione: 2

Experts

1.	Choi, Yeon Ja: 2 articles (10/2013 - 08/2013)
2.	Chun, Pusoon: 2 articles (10/2013 - 08/2013)
3.	Chung, Hae Young: 2 articles (10/2013 - 08/2013)
4.	Chung, Ki Wung: 2 articles (10/2013 - 08/2013)
5.	Ha, Young Mi: 2 articles (10/2013 - 08/2013)
6.	Kim, So Hee: 2 articles (10/2013 - 08/2013)
7.	Lee, Hye Jin: 2 articles (10/2013 - 08/2013)
8.	Moon, Hyung Ryong: 2 articles (10/2013 - 08/2013)
9.	Moon, Kyoung Mi: 2 articles (10/2013 - 08/2013)
10.	Jeong, Hyoung Oh: 1 article (10/2013)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

10/01/2013 - "When tested in B16F10 melanoma cells treated with α-melanocyte stimulating hormone (α-MSH), MHY498 inhibited murine tyrosinase activity and decreased melanin production without inducing cytotoxicity. "
08/01/2013 - "MHY498 inhibited 200 μM sodium nitroprusside (SNP, a NO donor)-induced NO generation, dose-dependently and suppressed tyrosinase activity and melanin synthesis induced by SNP in B16F10 melanoma cells. "

Related Drugs and Biologics

1.	Monophenol Monooxygenase (Tyrosinase)
2.	Melanins (Melanin)
3.	Nitroprusside (Sodium Nitroprusside)
4.	Melanocyte-Stimulating Hormones (MSH)