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7- ((4- hydroxy- 1,2,4a,5- tetramethyl- 6- oxo- 3,4,5,7,8,8a- hexahydro- 2H- naphthalen- 1- yl)methoxy)chromen- 2- one

inhibits Rho-associated kinase 2; isolated from Ferula assafoetida; structure in first source

Also Known As:

kamolonol

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        7-((4-hydroxy-1,2,4a,5-tetramethyl-6-oxo-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl)methoxy)chromen-2-one: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        7-((4-hydroxy-1,2,4a,5-tetramethyl-6-oxo-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl)methoxy)chromen-2-one: 1
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - 7-((4-hydroxy-1,2,4a,5-tetramethyl-6-oxo-3,4,5,7,8,8a-hexahydro-2H-naphthalen-1-yl)methoxy)chromen-2-one: 1

Experts

1.	Kim, Mun Sun: 1 article (08/2013)
2.	Lee, Byung Ho: 1 article (08/2013)
3.	Lee, Jeong Hyun: 1 article (08/2013)
4.	Mun, Jihye: 1 article (08/2013)
5.	Oh, Kwang-Seok: 1 article (08/2013)
6.	Ryu, Shi Yong: 1 article (08/2013)

Related Diseases

1.

08/23/2013 - "Taken together, these results indicate that kamolonol suppresses Ang II-induced stress fiber formation and cellular hypertrophy, and propose that one mechanism underlying these anti-fibrotic and anti-cellular hypertrophic effects involves inhibition of the ROCK-MLC pathway. "
08/23/2013 - "Furthermore, kamolonol (3-30μM) showed a potent inhibitory effect on Ang II-induced cellular hypertrophy in H9c2 cells. "
08/23/2013 - "Kamolonol suppresses angiotensin II-induced stress fiber formation and cellular hypertrophy through inhibition of Rho-associated kinase 2 activity."

Related Drugs and Biologics

1.	rho-Associated Kinases
2.	Angiotensin II