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3,7-dioxolanosta-8,24-dien-26-oic acid

isolated from the mushroom Ganoderma lucidum

Also Known As:

ganoderic acid DM

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - 3,7-dioxolanosta-8,24-dien-26-oic acid: 8

Experts

1.	Doonan, Bently P: 3 articles (01/2019 - 01/2010)
2.	Haque, Azizul: 3 articles (01/2019 - 01/2010)
3.	God, Jason M: 2 articles (01/2019 - 10/2012)
4.	Hossain, Azim: 2 articles (01/2019 - 10/2012)
5.	Johnson, Benjamin M: 2 articles (01/2019 - 01/2010)
6.	Radwan, Faisal F Y: 2 articles (01/2019 - 10/2012)
7.	Dai, Lujun: 1 article (01/2020)
8.	Wang, Liusheng: 1 article (01/2020)
9.	Xia, Junbo: 1 article (01/2020)
10.	Zhu, Jing: 1 article (01/2020)

Related Diseases

1.	Meningioma (Meningiomas) 09/01/2015 - "These results provide preliminary strong evidence that medicinal plants containing Limonin, Tangeritin, 6-Gingerol, Zerumbone, Ganoderic Acid A, and Ganoderic Acid DM can be applied to high-grade meningiomas as a therapeutic agent, and suggests that further in vivo studies are necessary to explore its potential as a therapeutic agent against malignant meningiomas." 09/01/2015 - "Limonin, Tangeritin, Zerumbone, 6-Gingerol, Ganoderic Acid A, and Ganoderic Acid DM are some of the plant derivatives that have anti-tumorgenic properties and cause cell death in meningioma cells in vitro. " 09/01/2015 - "Results indicated that treatments of IOMM-Lee and CH157MN meningioma cells with Limonin, Tangeritin, Zerumbone, 6-Gingerol, Ganoderic Acid A, and Ganoderic Acid DM induced apoptosis with enhanced phosphorylation of glycogen synthase kinase 3 β (GSK3β) via inhibition of the Wnt5/β-catenin pathway. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2010 - "Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer." 01/01/2010 - "Interestingly, ganoderic acid DM (GA-DM) has shown toxicity to both androgen-dependent and independent prostate cancer cells with reduced osteoclastogenesis in late stage metastatic disease. " 04/15/2009 - "Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis." 01/01/2019 - "We aimed to investigate the molecular mechanisms underlying the anticancer effects of a natural triterpenoid, ganoderic acid DM (GA-DM), on two human prostate cancer cell lines: the androgen-independent prostate carcinoma (PC-3), and androgen-sensitive prostate adenocarcinoma (LNCaP). "
3.	Melanoma (Melanoma, Malignant) 10/01/2012 - "Here, we report for the first time that a natural triterpenoid, Ganoderic acid DM (GA-DM), induces an orchestrated autophagic and apoptotic cell death, as well as enhanced immunological responses via increased HLA class II presentation in melanoma cells. "
4.	Human Influenza (Influenza) 04/01/2016 - "Further analysis revealed that ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir. "
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/25/2020 - "Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity."

Related Drugs and Biologics

1.	ganoderic acid A
2.	zerumbone
3.	tangeretin
4.	gingerol
5.	limonin
6.	Triterpenes
7.	Androgens
8.	Oseltamivir (Tamiflu)
9.	Catenins
10.	Glycogen Synthase Kinase 3