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4- (3,4- dichlorophenyl)- 4,5- dihydrooxazol- 2- ylamine

partial agonist of trace amine-associated receptor 1 (TAAR1)

Also Known As:

RO5203648

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - 4-(3,4-dichlorophenyl)-4,5-dihydrooxazol-2-ylamine: 2

Experts

1.	Li, Jun-Xu: 1 article (12/2021)
2.	Wu, Ruyan: 1 article (12/2021)
3.	Biemans, Barbara: 1 article (12/2012)
4.	Bradaia, Amyaouch: 1 article (12/2012)
5.	Canales, Juan J: 1 article (12/2012)
6.	Caron, Marc G: 1 article (12/2012)
7.	Ferragud, Antonio: 1 article (12/2012)
8.	Gainetdinov, Raul R: 1 article (12/2012)
9.	Groebke Zbinden, Katrin: 1 article (12/2012)
10.	Harmeier, Anja: 1 article (12/2012)

Related Diseases

1.	Substance-Related Disorders (Drug Abuse) 12/01/2021 - "Selective and potent engineered TAAR1 ligands, including full (RO5166017 and RO5256390) and partial (RO5203648, RO5263397 and RO5073012) agonists and the antagonist EPPTB (N-(3-ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl) benzamide, RO5212773), serve as invaluable tools for the investigation of TAAR1 functions and display significant potential for the development of TAAR1-based pharmacotherapies for the treatment of substance use disorders. "
2.	Central Nervous System Diseases (CNS Diseases) 12/01/2012 - "The TAAR1 partial agonist RO5203648 was evaluated for its binding affinity and functional activity at rodent and primate TAAR1 receptors stably expressed in HEK293 cells, for its physicochemical and pharmacokinetic properties, for its effects on the firing frequency of monoaminergic neurons ex vivo, and for its properties in vivo with genetic and pharmacological models of central nervous system disorders. "

Related Drugs and Biologics

1.	Ligands
2.	RO5166017
3.	(4- chlorophenyl)- (1H- imidazol- 4- ylmethyl)- isopropyl- amine
4.	RO5256390
5.	4- (3- fluoro- 2- methylphenyl)- 4,5- dihydrooxazol- 2- ylamine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)