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N- methyl- 1- cyclopropyl- 1- piperonylmethylamine

UWA-121 and UWA-122 are the (R)- and (S)-isomers, respectively

Also Known As:

2-(benzo(d)dioxol-5-yl)-1-cyclopropyl-N-methylethanamine; UWA-101; UWA-121; UWA-122

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Methylamines: 15
    - N-methyl-1-cyclopropyl-1-piperonylmethylamine: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - N-methyl-1-cyclopropyl-1-piperonylmethylamine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzodioxoles: 3
      - N-methyl-1-cyclopropyl-1-piperonylmethylamine: 2

Experts

1.	Brotchie, Jonathan M: 2 articles (07/2014 - 01/2012)
2.	Fox, Susan H: 2 articles (07/2014 - 01/2012)
3.	Huot, Philippe: 2 articles (07/2014 - 01/2012)
4.	Johnston, Tom H: 2 articles (07/2014 - 01/2012)
5.	Piggott, Matthew J: 2 articles (07/2014 - 01/2012)
6.	Reyes, M Gabriela: 2 articles (07/2014 - 01/2012)
7.	Koprich, James B: 1 article (07/2014)
8.	Lewis, Katie D: 1 article (07/2014)
9.	Gandy, Michael N: 1 article (01/2012)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/2012 - "UWA-101 did not exacerbate the severity of dyskinesia (P>0.05). " 01/01/2012 - "UWA-101 (10 mg/kg) significantly extended duration of ON-time without disabling dyskinesia (by 62%, P<0.01). " 07/01/2014 - "UWA-121 did not worsen the severity of dyskinesia or psychosis-like behaviours (P > 0.05). " 07/01/2014 - "UWA-122 is a selective SERT inhibitor (Ki 120 nM, Ki at DAT > 50 μM) and, in combination with L-DOPA, had no effect on ON-time, dyskinesia or psychosis-like behaviours (P > 0.05). " 07/01/2014 - "UWA-121 also extended duration of ON-time without dyskinesia (by 215%, P < 0.05) and ON-time without psychosis-like behaviours when compared to L-DOPA/vehicle treatment (by 345%, P < 0.01). "
2.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2012 - "However, at the highest doses (6 and 10 mg/kg), UWA-101 increased the severity of psychosis-like behaviours (P<0.05). " 07/01/2014 - "UWA-121 did not worsen the severity of dyskinesia or psychosis-like behaviours (P > 0.05). " 07/01/2014 - "UWA-122 is a selective SERT inhibitor (Ki 120 nM, Ki at DAT > 50 μM) and, in combination with L-DOPA, had no effect on ON-time, dyskinesia or psychosis-like behaviours (P > 0.05). " 07/01/2014 - "UWA-121 also extended duration of ON-time without dyskinesia (by 215%, P < 0.05) and ON-time without psychosis-like behaviours when compared to L-DOPA/vehicle treatment (by 345%, P < 0.01). " 07/01/2014 - "UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset."

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